The effect of alpha-lipoic acid (ALA) supplementation on cardiovascular risk factors in men with chronic spinal cord injury: a clinical trial

Mohammadi, Vida; Khalili, Mohammad; Eghtesadi, Shahryar; Dehghani, Sirous; Jazayeri, Shima; Aghababaee, Sahar Keshtkar; Sabour, Hadis; Saberi, Hooshang; Eghtesadi, Maryam; Gohari, Mahmoodreza

doi:10.1038/sc.2015.35

Cited by 38 publications

(60 citation statements)

References 32 publications

(38 reference statements)

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“…[131430] Authors mentioned that a possible reason for the difference between their result and the other studies could be due to the inherent physical differences associated with these study participants. [20] Results of the other study,[22] with a significant effect of ALA on BP, can be explained through mentioned mechanism.…”

Section: Discussionmentioning

confidence: 85%

“…[20] assessed the effect of ALA supplementation on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in male patients with chronic spinal cord injury. They prescribed 600 mg ALA for 12 weeks and then compared within and between groups’ changes.…”

Section: Resultsmentioning

confidence: 99%

“…Five studies indicate no significant effects for ALA supplementation on BP,[2324252627] but two trials on chronic spinal cord injury males[20] and type 2 diabetic patients[22] reported significant effects for this antioxidant on both SBP and DBPs.…”

Section: Resultsmentioning

confidence: 99%

“…[1314] In addition, ALA can increase nitric oxide production and improve endothelial function, therefore affects BP. [21] Mohammadi et al .,[20] in their study on chronic spinal cord injury patients, reported a significant reduction in SBP and DBP within ALA group and in comparison with placebo. These findings can be explained by rising effect of the supplement on reduced GSH levels in tissues GSH peroxidase activity and nitric oxide production in endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…[1415] Besides the antioxidant properties of ALA, nitric oxide synthesis can be increased by ALA, which may improve endothelial function. [16] Several animal[171819] and human[202122] studies investigated the effect of ALA on BP and some introduced it as a potential BP regulator. To the best of our knowledge, there is no systematic review in this field; moreover, the results of studies are contradictory.…”

Section: Introductionmentioning

confidence: 99%

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Does alpha-lipoic acid supplement regulate blood pressure? A systematic review of randomized, double-blind placebo-controlled clinical trials

2017

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Although several animal and human studies have investigated the effect of alpha-lipoic acid (ALA) on blood pressure (BP), these findings are inconsistent. This systematic review of randomized clinical trials was conducted to summarize the evidence on the effect of ALA on BP. PubMed, SCOPUS, and Google Scholar databases were searched based on MESH term (“Thioctic acid” in combination with “Hypertension” and “Blood pressure”) to identify related papers published up to December 2015. We summarized the results of the relevant studies in this review. In total, nine studies included in this review, seven parallel-designed trials and two crossover-designed trials. The results of parallel-designed studies are inconsistent. Five studies indicate no significant effects for ALA supplementation on BP, but two trials show effects on BP. Unlike parallel-designed trials, two crossover-designed trials have shown similar results and both report no effect for ALA on BP. Several studies investigated the effect of ALA on BP. Most of the papers show no significant effect for supplementation and the studies have shown that associations are limited. However, these findings are limited and there is a need for further and more accurate researches to be clarified.

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Section: Discussionmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Does alpha-lipoic acid supplement regulate blood pressure? A systematic review of randomized, double-blind placebo-controlled clinical trials

2017

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Mapping of Dietary Interventions Beneficial in the Prevention of Secondary Health Conditions in Spinal Cord Injured Population: A Systematic Review

Stojic

Eriks‐Hoogland

Gamba

et al. 2023

The Journal of nutrition, health and aging

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Objectives Individuals with spinal cord injury are at risk of secondary health conditions (SHC) that develop as a consequence of autonomic dysfunction, prolonged oxidative stress and inflammation, and physical inactivity coupled with inadequate energy and nutritional intake. SHC can be debilitating and even life-threatening, and its prevention remains one of the major challenges in the continuum of medical care of aging SCI population. An unhealthy diet is a major driver of inflammation, oxidative stress, and unfavourable metabolic status and may be a practical preventive target to tackle increased SHC risk post-injury. Aims To provide a catalogue of dietary interventions beneficial in prevention of SHC among individuals with SCI by conducting a systematic review of the literature on dietary interventions and dietary supplementation in promoting health and well-being after the injury. In addition, we aimed to provide a summary of observational studies exploring the association between habitual diet (macro- and micronutrients intake and dietary patterns) and health patterns following the injury. Method This review was registered at PROSPERO (University of York) with registration number CRD42022373773. Four medical databases (EMBASE.com, MEDLINE [Ovid], Cochrane CENTRAL, and Web of Science Core Collection) and Google Scholar were searched from inception until 11th July 2022. Studies were included if they were clinical trials or observational studies conducted in adult individuals with SCI and provided information of interest. Based on strength of the study design and risk of bias assessment (using the NIH tool), we classified studies from Level 1 (most reliable studies) to Level 4 (least reliable studies). Results Of 12,313 unique citations, 47 articles (based on 43 original studies) comprising 32 interventional (22 RCTs, 3 NRCT, and 7 pre-post studies) and 11 observational studies (2 cohort studies, 2 case-control, 1 post-intervention follow-up study, and 6 cross-sectional studies) were included in the present systematic review. Twenty studies (46.5%) were classified as Level 1 or 2, indicating high/moderate methodological quality. Based on those studies, dietary strategies including high protein diet, intermittent fasting, balanced diet in combination with physical conditioning and electrical stimulation, and dietary supplementation including alpha-lipoic acid, creatine, vitamin D, and cranberry-derived supplements and probiotics were mapped as the most promising in prevention of SHC among individuals with SCI. Conclusions To develop timely and effective preventive strategies targeting major SHC (e.g., cardiometabolic diseases, urinary tract infections) in SCI, further research is warranted to confirm the effectiveness of dietary strategies/interventions identified through the current systematic review of the literature.

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Influence of dietary alpha-lipoic acid and lipid level on the growth performance, food intake and gene expression of peripheral appetite regulating factors in juvenile grass carp (Ctenopharyngodon idellus)

Huang

Sun

et al. 2019

Aquaculture

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The effect of alpha-lipoic acid (ALA) supplementation on cardiovascular risk factors in men with chronic spinal cord injury: a clinical trial

Cited by 38 publications

References 32 publications

Does alpha-lipoic acid supplement regulate blood pressure? A systematic review of randomized, double-blind placebo-controlled clinical trials

Does alpha-lipoic acid supplement regulate blood pressure? A systematic review of randomized, double-blind placebo-controlled clinical trials

Mapping of Dietary Interventions Beneficial in the Prevention of Secondary Health Conditions in Spinal Cord Injured Population: A Systematic Review

Influence of dietary alpha-lipoic acid and lipid level on the growth performance, food intake and gene expression of peripheral appetite regulating factors in juvenile grass carp (Ctenopharyngodon idellus)

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