Oral administration of PET tracers: Current status

Souza, Giordana Salvi de; Mantovani, Dimitri B A; Mossel, Pascalle; Haarman, Bartholomeus C M; Silva, Ana Maria Marques da; Boersma, Hendrikus; Furini, Cristiane Regina Guerino; Lammertsma, Adriaan A.; Tsoumpas, Charalampos; Luurtsema, Gert

doi:10.1016/j.jconrel.2023.04.008

Cited by 3 publications

(4 citation statements)

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Section: Resultsmentioning

confidence: 99%

“…, food intake, gastric pH), leading to unstable kinetics [ 63 ]. In contrast, IV administration allows for more precise control of the dose and timing of the tracer than oral intake, ensuring uniform distributions of the tracer throughout the body and benefiting a more precise kinetic quantification [ 63 ]. Nevertheless, a rapid IV bolus administration might affect the physiology of the body ( e.g.…”

Section: Resultsmentioning

confidence: 99%

“…DMI Deuterium metabolic imaging, Glx Glutamine and glutamate, TCA Tricarboxylic acid, tCho Total choline pool, TERT Telomerase reverse transcriptase, PARP Poly adenosine diphosphate-ribose polymerase infusion, applying a bolus variable infusion protocol, and IV bolus injection followed by oral intake. Oral administration is the only attempted administration route in humans so far, but it may result in delayed or variable tracer absorption, depending on a range of varying factors (e.g., food intake, gastric pH), leading to unstable kinetics [63]. In contrast, IV administration allows for more precise control of the dose and timing of the tracer than oral intake, ensuring uniform distributions of the tracer throughout the body and benefiting a more precise kinetic quantification [63].…”

Section: Specific Physiological Conditionsmentioning

confidence: 99%

“…Oral administration is the only attempted administration route in humans so far, but it may result in delayed or variable tracer absorption, depending on a range of varying factors (e.g., food intake, gastric pH), leading to unstable kinetics [63]. In contrast, IV administration allows for more precise control of the dose and timing of the tracer than oral intake, ensuring uniform distributions of the tracer throughout the body and benefiting a more precise kinetic quantification [63]. Nevertheless, a rapid IV bolus administration might affect the physiology of the body (e.g., changes in blood pressure, heart rate) and alter the intracellular metabolic states in some cases by competing receptors, transporters, and enzymes [31,72,77].…”

Section: Specific Physiological Conditionsmentioning

confidence: 99%

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Advances and prospects in deuterium metabolic imaging (DMI): a systematic review of in vivo studies

Pan,

Liu,

Wan

et al. 2024

Eur Radiol Exp

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Background Deuterium metabolic imaging (DMI) has emerged as a promising non-invasive technique for studying metabolism in vivo. This review aims to summarize the current developments and discuss the futures in DMI technique in vivo. Methods A systematic literature review was conducted based on the PRISMA 2020 statement by two authors. Specific technical details and potential applications of DMI in vivo were summarized, including strategies of deuterated metabolites detection, deuterium-labeled tracers and corresponding metabolic pathways in vivo, potential clinical applications, routes of tracer administration, quantitative evaluations of metabolisms, and spatial resolution. Results Of the 2,248 articles initially retrieved, 34 were finally included, highlighting 2 strategies for detecting deuterated metabolites: direct and indirect DMI. Various deuterated tracers (e.g., [6,6′-2H2]glucose, [2,2,2′-2H3]acetate) were utilized in DMI to detect and quantify different metabolic pathways such as glycolysis, tricarboxylic acid cycle, and fatty acid oxidation. The quantifications (e.g., lactate level, lactate/glutamine and glutamate ratio) hold promise for diagnosing malignancies and assessing early anti-tumor treatment responses. Tracers can be administered orally, intravenously, or intraperitoneally, either through bolus administration or continuous infusion. For metabolic quantification, both serial time point methods (including kinetic analysis and calculation of area under the curves) and single time point quantifications are viable. However, insufficient spatial resolution remains a major challenge in DMI (e.g., 3.3-mL spatial resolution with 10-min acquisition at 3 T). Conclusions Enhancing spatial resolution can facilitate the clinical translation of DMI. Furthermore, optimizing tracer synthesis, administration protocols, and quantification methodologies will further enhance their clinical applicability. Relevance statement Deuterium metabolic imaging, a promising non-invasive technique, is systematically discussed in this review for its current progression, limitations, and future directions in studying in vivo energetic metabolism, displaying a relevant clinical potential. Key points • Deuterium metabolic imaging (DMI) shows promise for studying in vivo energetic metabolism. • This review explores DMI’s current state, limits, and future research directions comprehensively. • The clinical translation of DMI is mainly impeded by limitations in spatial resolution. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%