Oral administration of lipoteichoic acid from <i>Lactobacillus rhamnosus</i> GG overcomes UVB‐induced immunosuppression and impairs skin tumor growth in mice

Friedrich, A; Campo, Valeria E.; Maiten, Eliana; Morelli, Adrián E.; Shufesky, William J.; Tckacheva, Olga A.; Leoni, Juliana; Paz, Mariela L.; Larregina, Adriana T.; Maglio, Daniel Horacio González

doi:10.1002/eji.201848024

Cited by 24 publications

(22 citation statements)

References 24 publications

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“…On the other hand, changes in the intestinal microbiota and intake of probiotics can affect the immune response of the skin. In fact, lipoteichoic acid (LTA) from LGG ( Lactobacillus rhamnosus ) can prevent skin tumors in mice exposed to long-term ultraviolet rays ( Friedrich et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Nicotinamide Mononucleotide Combined With Lactobacillus fermentum TKSN041 Reduces the Photoaging Damage in Murine Skin by Activating AMPK Signaling Pathway

Zhou

et al. 2021

Front. Pharmacol.

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Long-term exposure to UVB (280–320 nm) can cause oxidative skin damage, inflammatory injury, and skin cancer. Research on nicotinamide mononucleotide (NMN) and lactic acid bacteria (LAB) with regard to antioxidation, anti-inflammation, and prevention of other age-related diseases has received increasing attention. In the present study, the in vitro antioxidant analysis showed that NMN combined with Lactobacillus fermentum TKSN041 (L. fermentum TKSN041) has a high scavenging ability on hydroxyl (OH), 2, 2′-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) diammonium salt (ABTS) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH), and it also possess a good total antioxidant capacity. The animal experimental results show that NMN combined with LAB maintained normal liver morphology of mice and reduced pathological damage to murine skin. NMN combined with LAB significantly increased the serum levels of total superoxide dismutase (T-SOD), catalase (CAT), and interleukin (IL)-10, but reduced the levels of malondialdehyde, advanced glycation end products, tumor necrosis factor (TNF)-α, and IL-6. NMN combined with LAB increased T-SOD, CAT, IL-10, Na+-K+-ATPase, and NAD+ levels in the skin, but reduced TNF-α level in the skin. NMN combined with LAB increased the mRNA expression levels of SOD1, CAT, glutathione (GSH), inhibitor of NF-κB (IκB-α), IL-10, AMP-activated protein kinase (AMPK), adaptor protein, phosphotyros ineinteraction, PH domain and leucine zipper containing 1 (APPL1), peroxisome proliferator-activated receptor γ co-activator-1α (PGC-1α), and forkhead transcription factor O (FOXO) in the skin and liver, but decreased the mRNA expression levels of nuclear factor (NF)-κBp65, TNF-α, IL-6, and rapamycin target protein (mTOR). NMN combined with LAB increased the protein expression levels of AMPK, IκB-α, SOD1, and CAT in the skin tissues and reduced protein expression of NF-κBp65. NMN combined with L. fermentum TKSN041 improved murine skin damage caused by UVB irradiation, and the protective mechanism may be related to activation of the AMPK signaling pathway. The results of this study are expected to provide a reference for preventing and the treating skin photoaging.

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Section: Introductionmentioning

confidence: 99%

Nicotinamide Mononucleotide Combined With Lactobacillus fermentum TKSN041 Reduces the Photoaging Damage in Murine Skin by Activating AMPK Signaling Pathway

Zhou

et al. 2021

Front. Pharmacol.

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“…Specific strains of lactic acid bacteria may have a beneficial influence on the composition and metabolism of the intestinal microbiota and in some cases have been reported to inhibit the growth of enteropathogenic bacteria [ 72 ]. Many studies have shown a connection between the intestinal immune axis and the skin [ 74 ] and consumption of food containing probiotics was shown to improve skin health, maintaining skin homeostasis and regulating the cutaneous immune system [ 49 ].…”

Section: Photoprotectionmentioning

confidence: 99%

“…In the same way, the administration of a probiotic strain of Lactobacillus rhamnosus GG (LGG) was demonstrated to prevent the development of skin tumors thanks to the activity of its lipoteichoic acid (LTA), a component of the Gram-positive bacteria cell wall. In a murine model, LTA decreased UV-induced skin immunosuppression and thus significantly reduced UV-induced skin tumor growth [ 74 ]. Other photoprotective candidates can be considered, such as Lactobacillus plantarum HY7714, Bifidobacterium breve and Bifidobacterium longum [ 75 , 77 , 78 ].…”

Section: Photoprotectionmentioning

confidence: 99%

Challenging Cosmetic Innovation: The Skin Microbiota and Probiotics Protect the Skin from UV-Induced Damage

Souak

Barreau

Courtois³

et al. 2021

Microorganisms

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Many studies performed in the last decade have focused on the cutaneous microbiota. It has been shown that this microbiota plays a key role in skin homeostasis. Considered as “a second barrier” to the environment, it is very important to know how it reacts to exogenous aggressions. The cosmetics industry has a started to use this microbiota as a source of natural ingredients, particularly ones that confer photoprotection against ultraviolet (UV) rays. Interestingly, it has been demonstrated that bacterial molecules can block UV rays or reverse their harmful effects. Oral probiotics containing living microorganisms have also shown promising results in restoring skin homeostasis and reversing the negative effects of UV rays. Microbial-based active sunscreen compounds have huge potential for use as next-generation photoprotection products.

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“…lipoteichoic acid produced a reduction in squamous cell carcinomas in chronically UV-exposed mice, reinforcing Th1 response ( Weill et al, 2013 ). Moreover, this treatment was also effective in preventing UV-induced immunosuppression ( Friedrich et al, 2019 ). In addition, the oral treatment with Bifidobacterium spp.…”

Section: Mechanism Of Action Of Probioticsmentioning

confidence: 99%

Searching for the one(s): Using Probiotics as Anthelmintic Treatments

Saracino¹,

Vila²,

Baldi³

et al. 2021

Front. Pharmacol.

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Helminths are a major health concern as over one billion people are infected worldwide and, despite the multiple efforts made, there is still no effective human vaccine against them. The most important drugs used nowadays to control helminth infections belong to the benzimidazoles, imidazothiazoles (levamisole) and macrocyclic lactones (avermectins and milbemycins) families. However, in the last 20 years, many publications have revealed increasing anthelmintic resistance in livestock which is both an economical and a potential health problem, even though very few have reported similar findings in human populations. To deal with this worrying limitation of anthelmintic drugs, alternative treatments based on plant extracts or probiotics have been developed. Probiotics are defined by the Food and Agriculture Organization as live microorganisms, which, when consumed in adequate amounts, confer a health benefit to the host. It has been proven that probiotic microbes have the ability to exert an immunomodulatory effect both at the mucosa and the systemic level. The immune response against gastrointestinal helminths is characterized as a type 2 response, with high IgE levels, increased numbers and/or activity of Th2 cells, type 2 innate lymphoid cells, eosinophils, basophils, mast cells, and alternatively activated macrophages. The oral administration of probiotics may contribute to controlling gastrointestinal helminth infections since it has been demonstrated that these microorganisms stimulate dendritic cells to elicit a type 2 or regulatory immune response, among other effects on the host immune system. Here we review the current knowledge about the use of probiotic bacteria as anthelmintic therapy or as a complement to traditional anthelmintic treatments. Considering all research papers reviewed, we may conclude that the effect generated by probiotics on helminth infection depends not only on the parasite species, their stage and localization but also on the administration scheme.

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Oral administration of lipoteichoic acid from Lactobacillus rhamnosus GG overcomes UVB‐induced immunosuppression and impairs skin tumor growth in mice

Cited by 24 publications

References 24 publications

Nicotinamide Mononucleotide Combined With Lactobacillus fermentum TKSN041 Reduces the Photoaging Damage in Murine Skin by Activating AMPK Signaling Pathway

Nicotinamide Mononucleotide Combined With Lactobacillus fermentum TKSN041 Reduces the Photoaging Damage in Murine Skin by Activating AMPK Signaling Pathway

Challenging Cosmetic Innovation: The Skin Microbiota and Probiotics Protect the Skin from UV-Induced Damage

Searching for the one(s): Using Probiotics as Anthelmintic Treatments

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