Oral administration of Lactobacillus paracasei N1115 on neonatal mice prevents the intestinal inflammation in adulthood

Xun, Yiping; Yan, Fang; Zhu, Hong; Li, Feng; Zhang, Dong; Yang, Xue; He, Fang; Wang, Shijie

doi:10.1111/lam.13729

Cited by 4 publications

(3 citation statements)

References 33 publications

(59 reference statements)

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“…To conclude, this study supports the notion that early postnatal nutrition is crucial for proper gut microbial colonization and that prebiotic fiber supplementation during this critical period of development might contribute to the improvement of the protective properties in altered nutritional environments. However, the consequences of such modifications for gut microbiota during postnatal development and in response to PNGR on later intestinal health and susceptibility to chronic intestinal diseases remain to be investigated [ 5 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Prebiotic Supplementation during Lactation Affects Microbial Colonization in Postnatal-Growth-Restricted Mice

et al. 2023

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Background: An inadequate perinatal nutritional environment can alter the maturation of the intestinal barrier and promote long-term pathologies such as metabolic syndrome or chronic intestinal diseases. The intestinal microbiota seems to play a determining role in the development of the intestinal barrier. In the present study, we investigated the impact of consuming an early postnatal prebiotic fiber (PF) on growth, intestinal morphology and the microbiota at weaning in postnatal-growth-restricted mice (PNGR). Methods: Large litters (15 pups/mother) were generated from FVB/NRj mice to induce PNGR at postnatal day 4 (PN4) and compared to control litters (CTRL, 8 pups/mother). PF (a resistant dextrin) or water was orally administered once daily to the pups from PN8 to PN20 (3.5 g/kg/day). Intestinal morphology was evaluated at weaning (PN21) using the ileum and colon. Microbial colonization and short-chain fatty acid (SCFA) production were investigated using fecal and cecal contents. Results: At weaning, the PNGR mice showed decreased body weight and ileal crypt depth compared to the CTRL. The PNGR microbiota was associated with decreased proportions of the Lachnospiraceae and Oscillospiraceae families and the presence of the Akkermansia family and Enterococcus genus compared to the CTRL pups. The propionate concentrations were also increased with PNGR. While PF supplementation did not impact intestinal morphology in the PNGR pups, the proportions of the Bacteroides and Parabacteroides genera were enriched, but the proportion of the Proteobacteria phylum was reduced. In the CTRL pups, the Akkermansia genus (Verrucomicrobiota phylum) was present in the PF-supplemented CTRL pups compared to the water-supplemented ones. Conclusions: PNGR alters intestinal crypt maturation in the ileum at weaning and gut microbiota colonization. Our data support the notion that PF supplementation might improve gut microbiota establishment during the early postnatal period.

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Section: Discussionmentioning

confidence: 99%

Prebiotic Supplementation during Lactation Affects Microbial Colonization in Postnatal-Growth-Restricted Mice

et al. 2023

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“…Meanwhile, L. paracacei BD5115 promotes the proliferation of intestinal epithelial cells ( Qiao et al, 2022 ). Notably, neonatal administration of L. paracacei N1115 prevents intestinal inflammation in adulthood in mice ( Xun et al, 2022 ). A randomized controlled clinical trial has shown that oral administration of L. paracacei CBA L74-fermented formula could enhance the immune system, microbiota, and metabolome maturation in infants ( Roggero et al, 2020 ) and that L. paracacei BD5115 may help repair intestinal damage.…”

Section: Therapeutic Effects Of Probiotics On Ucmentioning

confidence: 99%

Probiotics for the treatment of ulcerative colitis: a review of experimental research from 2018 to 2022

et al. 2023

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Ulcerative colitis (UC) has become a worldwide public health problem, and the prevalence of the disease among children has been increasing. The pathogenesis of UC has not been elucidated, but dysbiosis of the gut microbiota is considered the main cause of chronic intestinal inflammation. This review focuses on the therapeutic effects of probiotics on UC and the potential mechanisms involved. In animal studies, probiotics have been shown to alleviate symptoms of UC, including weight loss, diarrhea, blood in the stool, and a shortened colon length, while also restoring intestinal microecological homeostasis, improving gut barrier function, modulating the intestinal immune response, and attenuating intestinal inflammation, thereby providing theoretical support for the development of probiotic-based microbial products as an adjunctive therapy for UC. However, the efficacy of probiotics is influenced by factors such as the bacterial strain, dose, and form. Hence, the mechanisms of action need to be investigated further. Relevant clinical trials are currently lacking, so the extension of animal experimental findings to clinical application requires a longer period of consideration for validation.

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“…Lactobacillus paracasei N1115 (Lp N1115) was isolated from fermented milk products that have long been consumed by herders in Mongolia [24] and has potential probiotic properties such as the ability to promote intestinal development [25], improve intestinal symptoms [26], and regulate immunity [27]. However, the current research on Lp N1115 is mostly conducted on animals or in adults, and fewer trials are conducted on infants and young children.…”

Section: Introductionmentioning

confidence: 99%

Effect of Lacticaseibacillus paracasei N1115 on Immunomodulatory and Gut Microbial Composition in Young Children: A Randomized, Placebo-Controlled Study

Ren

Zhou

et al. 2023

Nutrients

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Lactobacillus paracasei N1115 (Lp N1115) was isolated from fermented milk products. The administration of Lp N1115 is safe and well tolerated in Chinese children, but its effectiveness among young Chinese children is still unclear. To investigate the efficacy of Lp N1115 as a probiotic to enhance gut development in Chinese infants and toddlers born by cesarean section, 109 healthy and cesarean-delivered infants aged 6–24 months were recruited for a 12-week randomized, placebo-controlled trial, with 101 finally completing the study. Saliva and stool samples were collected and detected at weeks 0, 4, 8, and 12 of the intervention. Statistical analyses were performed by using a per-protocol (PP) approach. After 12 weeks of intervention, the fecal pH in the control group increased (p = 0.003), while the fecal pH in the experimental group did not change. Salivary cortisol decreased from baseline in the experimental group (p = 0.023), while the control group showed little change. In addition, Lp N1115 increased the fecal sIgA content of infants aged 6–12 months (p = 0.044) but had no obvious effect on fecal calprotectin and saliva sIgA. At week 4, the increase in Lactobacillus relative to baseline was higher in the experimental group than in the control group (p = 0.019). Further analysis showed a trend toward a higher detection rate of Lactobacillus in the experimental group than in the control group (p = 0.039). In conclusion, Lp N1115 was able to enhance the content of Lactobacillus and maintain fecal pH levels. Its beneficial effects on gut development were more obvious in 6–12-month-old infants.

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Oral administration of Lactobacillus paracasei N1115 on neonatal mice prevents the intestinal inflammation in adulthood

Cited by 4 publications

References 33 publications

Prebiotic Supplementation during Lactation Affects Microbial Colonization in Postnatal-Growth-Restricted Mice

Prebiotic Supplementation during Lactation Affects Microbial Colonization in Postnatal-Growth-Restricted Mice

Probiotics for the treatment of ulcerative colitis: a review of experimental research from 2018 to 2022

Effect of Lacticaseibacillus paracasei N1115 on Immunomodulatory and Gut Microbial Composition in Young Children: A Randomized, Placebo-Controlled Study

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