Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear

Yeom, Mijung; Kim, Sunghun; Lee, Bombi; Han, Jeong-Jun; Chung, Guk Hoon; Choi, Hee‐Don; Lee, Hyejung; Hahm, Dae‐Hyun

doi:10.1016/j.jdermsci.2012.05.009

Cited by 39 publications

(28 citation statements)

References 48 publications

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“…Superficial epidermal hydration was the sole parameter showing a statistically significant difference between both age groups (p=0.0098) with a ≈ 43% reduction in older rats (OR) ( Figure 5). These values are similar to previously published results [22] obtained in the ear of Balb/c mice , and are especially relevant in the processes such as healing or patch dressing efficacy, where hydration is a critical determinant. The fact that the ageing process in rats has similarly affected skin hydration, and the fact that this change could be detected with our noninvasive technique, suggest that this may be of value in predicting, with human translational value, potential differential effects of topically applied products in aged vs young adults, in that which concerns safety or efficacy aspects.…”

Section: Resultssupporting

confidence: 90%

“…Estes valores são semelhantes a valores previamente publicados obtidos [22] na pele da orelha de "ratinhos" Balb/c , e são especialmente relevantes nos processos, tais como a recuperação cutânea, ou a eficácia de patch curativo, onde a hidratação é um determinante crítico. O facto de o processo de envelhecimento em ratos ter tido a hidratação da pele igualmente afectada e o facto de que essa alteração pode ser detectada com a nossa técnica não invasiva, sugerem que esta técnica pode ser de grande utilidade para prever a translação dos valores para o humano, potenciais efeitos diferenciais dos produtos aplicados topicamente em idosos vs jovens, no que diz respeito à aspectos de segurança ou eficácia.…”

Section: Resultsunclassified

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Rat skin physiology is modified by age

Sponchiado

Mello-Sampayo

Pereirra

et al. 2012

BBR

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J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Rat skin physiology is modified by age A Fisiologia da pele de rato é modificada pela idade __________________________________________________________________________________ AbstractAnimal models have been useful in the study of specific mechanisms affecting human skin. Such is the case with ageing and the micromechanical changes determining wrinkles in UV-irradiated mice. These models enabled us to understand that ageing encompasses many peculiar mechanical responses which cannot be explained by homogeneous deformation of the skin. Moreover, a major aspect to consider is that ageing processes differ among species and direct inferences are rarely possible. This project aimed to compare age-induced changes in skin properties by studying two Wistar rat groups of different ages -young adult rats (n=7, 20-24 week-old) and old adult rats (n=5, 48-72 week-old). Non-invasive measuring approaches involving transepidermal water loss (TEWL), superficial hydration (MoistureMeter), and biomechanics (Reviscometer, and Cutometer by MPA80) were taken in the animal dorsum (neck, bottom) over a period of five days, allowing statistical comparisons between groups. Results revealed no significant differences for TEWL, firmness or viscoelasticity between the two groups. However, a significant hydration decrease, of nearly 40%, was noted in the old adult rats group. These results, although preliminary, if translatable to humans could be useful to address age-related changes in processes such as healing, or patch dressing efficacy/safety where hydration is a critical determinant. Their potential use for the prediction of efficacy and or safety of topically applied products for the elderly as compared to young adults may warrant further investigation.. Os modelos animais têm sido úteis para estudar mecanismos específicos que afetam a pele humana. É o caso do envelhecimento e das alterações micromecânicas que determinam o enrugamento (a formação de rugas) nos ratinhos irradiados com UV. Estes modelos permitiram perceber que o envelhecimento envolve muitas respostas mecânicas peculiares que não podem ser explicadas pela deformação homogénea da pele. No entanto, a diferença entre o tempo de vida destas espécies afeta também os processos e este é um aspeto principal a ter em conta. Este projeto é direcionado à comparação das propriedades cutâneas de dois grupos de ratos Wistar com diferentes idades -ratos jovens-adultos (n=7, 20-24 semanas) e adultos-velhos (n=5, 48-72 semanas). Medições não-invasivas de perda transepidérmica de água (PTEA), hidratação superficial (MoistureMeter) e biomecânica (Reviscometer e Cutometer por MPA80) foram realizadas nas zonas dorsais (pescoço, dorso-posterior) do animal durante 5 dias, permitindo comparações estatísticas entre grupos. Os resultados não revelaram diferenças significativas para a PTEA, firmeza ou viscoelasticidade entre os dois grupos. Contudo, foi notada uma diminuição significativa, próxima de 40%, da ...

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Section: Resultssupporting

confidence: 90%

Section: Resultsunclassified

Rat skin physiology is modified by age

Sponchiado

Mello-Sampayo

Pereirra

et al. 2012

BBR

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“…In addition to in vitro studies, the beneficial effects of oral intake of plant-derived CERs for skin hydration and skin barrier reinforcement have been established in several studies involving animal models [14,15,110,111] as well as human subjects [14,106,109,112]. These studies were mostly conducted on detergent- or tape-stripped-perturbed human skin and/or hairless mouse skin [14,113] or on skin with diet-induced AD-like symptoms in animal models [114,115].…”

Section: Effect Of Oral Phytocer-based Dietary Supplements On Skin Bamentioning

confidence: 99%

Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function

Tessema

Gebre‐Mariam

Neubert

et al. 2017

Skin Pharmacol Physiol

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The outer most layer of the skin, the stratum corneum, consists of corneocytes which are coated by a cornified envelope and embedded in a lipid matrix of ordered lamellar structure. It is responsible for the skin barrier function. Ceramides (CERs) are the backbone of the intercellular lipid membranes. Skin diseases such as atopic dermatitis and psoriasis and aged skin are characterized by dysfunctional skin barrier and dryness which are associated with reduced levels of CERs. Previously, the effectiveness of supplementation of synthetic and animal-based CERs in replenishing the depleted natural skin CERs and restoring the skin barrier function have been investigated. Recently, however, the barrier function improving effect of plant-derived CERs has attracted much attention. Phyto-derived CERs (phytoCERs) are preferable due to their assumed higher safety as they are mostly isolated from dietary sources. The beneficial effects of phytoCER-based oral dietary supplements for skin hydration and skin barrier reinforcement have been indicated in several studies involving animal models as well as human subjects. Ingestible dietary supplements containing phytoCERs are also widely available on the market. Nonetheless, little effort has been made to investigate the potential cosmetic applications of topically administered phytoCERs. Therefore, summarizing the foregoing investigations and identifying the gap in the scientific data on plant-derived CERs intended for skin-health benefits are of paramount importance. In this review, an attempt is made to synthesize the information available in the literature regarding the effects of phytoCER-based oral dietary supplements on skin hydration and barrier function with the underlying mechanisms.

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“…In addition, although regulation down of claudin-1 in the skin epidermis is responsible for inflammatory cytokine interleulin-1, 17) it was recently reported that dietary GlcCer significantly suppressed mRNA expression of interleukin-1 in mouse epidermis. 21) Hence, our in vivo result might also be associated with the suppression of UVB-induced interleukin-1 expression by dietary GlcCer, above and beyound other indirect mechanisms. Although SS also increased TER in the NHEK cells, it had no significant effect on the claudin-1 mRNA level.…”

Section: )mentioning

confidence: 73%

Dietary Glucosylceramide Enhances Tight Junction Function in Skin Epidermis via Induction of Claudin-1

Kawada

Hasegawa

Watanabe

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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Dietary glucosylceramide increased the expression of claudin-1 in UVB-irradiated mouse epidermis. Sphingosine and phytosphingosine, metabolites of glucosylceramide, increased trans-epithelial electrical resistance, and phytosphingosine increased claudin-1 mRNA expression in cultured keratinocytes. Our results indicate that the skin barrier improvement induced by dietary glucosylceramide might be due to enhancement of tight junction function, mediated by increased expression of claudin-1 induced by sphingoid metabolites.

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Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear

Cited by 39 publications

References 48 publications

Rat skin physiology is modified by age

Rat skin physiology is modified by age

Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function

Dietary Glucosylceramide Enhances Tight Junction Function in Skin Epidermis via Induction of Claudin-1

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