Oral administration of geranylgeranylacetone to protect vestibular hair cells

Nagato, Shinpei; Sugahara, Kazuma; Hirose, Yoshio; Takemoto, Yousuke; Hashimoto, Makoto; Fujii, Hironori; Yamashita, Hiroshi

doi:10.1016/j.anl.2017.07.006

Cited by 2 publications

(2 citation statements)

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“…The application of AGs can result in a dramatic loss of vestibular HCs (May et al 2013 ; Nagato et al 2018 ; Yoshida et al 2015 ). With the dose of AGs elevated, the rate of vestibular HC loss increased (Lee et al 2014 ; Park et al 2007 ; Taleb et al 2008 ; Yousaf et al 2018 ).…”

Section: Proinflammatory Cytokine Expressionmentioning

confidence: 99%

“…Overexpression of HSP70 inhibits vestibular HC death from ototoxicity as well (May et al 2013 ). Furthermore, some factors, which can induce HSP70 in the vestibular end organs, such as geranylgeranylacetone (GGA) (Nagato et al 2018 ; Takumida and Anniko 2005 ) and pifithin-µ (Ryals et al 2018 ), also protect vestibular HCs from aminoglycoside-induced death. HSP32 is another heat shock protein that may prevent vestibular toxicity induced by cisplatin, and its protective effect is mediated by resident macrophages (Baker et al 2015 ).…”

Section: Protection Strategies Of Vestibular Hair Cellsmentioning

confidence: 99%

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Progress in protecting vestibular hair cells

Jiang

Zheng

2021

Arch Toxicol

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Vestibular hair cells are mechanosensory receptors that are capable of detecting changes in head position and thereby allow animals to maintain their posture and coordinate their movement. Vestibular hair cells are susceptible to ototoxic drugs, aging, and genetic factors that can lead to permanent vestibular dysfunction. Vestibular dysfunction mainly results from the injury of hair cells, which are located in the vestibular sensory epithelium. This review summarizes the mechanisms of different factors causing vestibular hair cell damage and therapeutic strategies to protect vestibular hair cells.

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