Oral Administration of a Hop Water Extract Ameliorates the Development of Dermatitis Induced by the Periodical Topical Application of a Mite Antigen in Atopic Dermatitis Model NC/Nga Mice

Segawa, Shuichi; Kuroda, Hisao; Kaneko, Toshihiro; Watari, Junji

doi:10.1271/bbb.70695

Cited by 8 publications

(6 citation statements)

References 33 publications

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“…In our present murine model, size-related effects were not observed, which could not be considered to be due to differences in the absorption/ penetration of nanoparticles because of the injection directly into the skin. Several previous studies have used the skinstripping methods as a model of skin barrier dysfunction/ defect in humans (53,54) and experimental animals (55,56). However, it is difficult to generate quantitatively skin barrier dysfunction/defect with identical severity.…”

Section: Discussionmentioning

confidence: 99%

Titanium Dioxide Nanoparticles Aggravate Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

Yanagisawa

Takano

Inoue

et al. 2009

Exp Biol Med (Maywood)

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Titanium dioxide (TiO(2)) nanoparticles are produced abundantly and used ubiquitously in various cosmetic products. However, it remains to be determined whether transdermal exposure to TiO(2) nanoparticles affects atopic dermatitis (AD), which has been increasing in developed countries. We investigated the effects of different sized TiO(2) nanoparticles on AD-like skin lesions induced to mite allergen in NC/Nga mice assumed to show skin barrier dysfunction/defect. Male mice were injected intradermally with TiO(2) nanoparticles of three sizes (15, 50, or 100 nm) and/or mite allergen into their right ears. We evaluated clinical scores, ear thickening, histological findings and the protein expression of T helper (Th) 1 and Th2 cytokines in the ear, and the levels of Ig and histamine in serum. TiO(2) nanoparticles aggravated AD-like skin lesions related to mite allergen in NC/ Nga mice. The enhancing effects are paralleled by the overproduction of IL-4 in the skin, the levels of total IgE and histamine in serum regarding the overall trend. In contrast, TiO(2) nanoparticles decreased the local expression of IFN-gamma in the presence of allergen. Additionally, TiO(2) nanoparticles alone significantly increased histamine levels in serum and IL-13 expression in the ear. However, different effects related to the size differences of TiO(2) nanoparticles were not observed. In conclusion, exposure to TiO(2) nanoparticles under skin barrier dysfunction/defect can exacerbate AD symptoms through Th2-biased immune responses. Furthermore, TiO(2) nanoparticles can play a significant role in the initiation and/or progression of skin diseases following the barrier dysfunction/defect by histamine release even in the absence of allergen.

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Section: Discussionmentioning

confidence: 99%

Titanium Dioxide Nanoparticles Aggravate Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

Yanagisawa

Takano

Inoue

et al. 2009

Exp Biol Med (Maywood)

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“…An elevated level of immunoglobulin E (IgE) antibodies and the infiltration of a variety of immune cells, such as lymphocytes, mast cells, eosinophils and neutrophils, are also characteristic features in this disease (Kang et al. 2008b; Segawa et al. 2008b).…”

Section: Introductionmentioning

confidence: 99%

Oral administration of Lactobacillus strains from Kimchi inhibits atopic dermatitis in NC / Nga mice

Won

Kim

Lim

et al. 2011

Journal of Applied Microbiology

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Aims: Atopic dermatitis (AD) is marked by elevated levels of immunoglobulin E and skin lesions such as oedema and haemorrhage. Kimchi is a Korean fermented food that contains beneficial bacteria for human health. In this study, Lactobacillus plantarum CJLP55, CJLP56, CJLP133 and CJLP136 isolated from Kimchi were investigated for their capacity to inhibit AD. Methods and Results: The three strains, CJLP55, CJLP133 and CJLP136, suppressed AD‐like skin lesions, high serum IgE levels and epidermal thickening. The three strains diminished the accumulation of eosinophils and mast cells into topical inflammatory sites and the enlargement of axillary lymph nodes, which are responsible for the dorsal dermatitis. CJLP55, CJLP133 and CJLP136 decreased production of type 2 cytokines such as IL‐4 and IL‐5 in lymph node cell culture. CJLP133 and CJLP136 increased IFN‐γ secretion, while CJLP55 enhanced IL‐10 production. Conclusions: The three strains isolated from Kimchi suppress house‐dust mite‐induced dermatitis in NC/Nga mouse, a representative animal model of human AD. Significance and Impact of the Study: These findings suggest that lactobacilli isolated from Kimchi inhibit AD, probably by altering the balance of Th1/Th2 ratio or inducing IL‐10 production.

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“…Atopic dermatitis (AD) is a type-1 allergic skin disease with an incidence that has steadily increased over the last several decades worldwide (Horii et al, 2007;Segawa et al, 2008b;Segawa et al, 2008c;Van Bever and Llanora, 2011). Type-1 allergies are caused by immunological hypersensitivity to a common substance, an allergen, and are associated with excess production of IgE antibodies against the allergen.…”

Section: Introductionmentioning

confidence: 99%

“…NC/Nga mice, an inbred strain established from Japanese fancy mice, develop AD-like skin lesions under conventional care or upon repeated challenge with 2,4,6-trinitrochlorobenzene (picryl chloride, PiCl; Tokyo Kasei Kogyo, Tokyo, Japan) under specific pathogen free (SPF) conditions (Kato et al, 2005;Matsuda et al, 1997;Sasakawa et al, 2001;Segawa et al, 2008c). Induced dermatitis is accompanied by elevated serum IgE levels, increased expression of Th2-type cytokines, eosinophil accumulation in the lesions and frequent scratching behavior, which are characteristic features of human AD (Segawa et al, 2008b;Segawa et al, 2008c).…”

Section: Introductionmentioning

confidence: 99%

Tetragenococcus halophilus MN45 Ameliorates Development of Atopic Dermatitis in Atopic Dermatitis Model NC/Nga Mice

Ohata

Yoshida

Masuda

et al. 2011

FSTR

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We investigated the inhibitory effects of oral administration of Tetragenococcus halophilus MN45 (MN45) isolated from miso on the development of atopic dermatitis (AD) using NC/Nga AD model mice. NC/Nga mice were fed a diet containing 0.05% or 0.5% MN45 (0.05% or 0.5% MN45 groups) or lacking MN45 (control group). Mice were sensitized and boosted with picryl chloride by topical application once per week. IgE production in serum, clinical score and ear thickness in both MN45 groups were significantly suppressed. In addition, IgE and IL-17 production from splenocytes from mice in both MN45 groups were significantly decreased. IL-4 production from splenocytes in the 0.5% MN45 group decreased significantly, while IL-10 production from splenocytes in the 0.05% MN45 group increased significantly. These results demonstrate that intake of MN45 is effective in preventing and alleviating the development of type-1 allergic symptoms in humans.

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Oral Administration of a Hop Water Extract Ameliorates the Development of Dermatitis Induced by the Periodical Topical Application of a Mite Antigen in Atopic Dermatitis Model NC/Nga Mice

Cited by 8 publications

References 33 publications

Titanium Dioxide Nanoparticles Aggravate Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

Titanium Dioxide Nanoparticles Aggravate Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

Oral administration of Lactobacillus strains from Kimchi inhibits atopic dermatitis in NC / Nga mice

Tetragenococcus halophilus MN45 Ameliorates Development of Atopic Dermatitis in Atopic Dermatitis Model NC/Nga Mice

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