Oral Absorption of Flucloxacillin in Infants and Young Children

Bergdahl, Sven; Eriksson, Margareta; Finkel, Yigael; Lännergren, Karin

doi:10.1111/j.1600-0773.1986.tb00105.x

Cited by 9 publications

(5 citation statements)

References 11 publications

(3 reference statements)

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“…The administration of flucloxacillin oral liquid to children can be a challenge and parent/carers should be supported with this task. Previous knowledge of the impact of food on the bioavailability of flucloxacillin in children is not conclusive . Regular reports of mixing flucloxacillin with food highlights the need for additional research to understand the impact on pharmacokinetics of co‐administration with food to improve palatability rather than dosing with a full meal.…”

Section: Resultsmentioning

confidence: 99%

“…Previous knowledge of the impact of food on the bioavailability of flucloxacillin in children is not conclusive. [18] Regular reports of mixing flucloxacillin with food highlights the need for additional research to understand the impact on pharmacokinetics of co-administration with food to improve palatability rather than dosing with a full meal. These data demonstrate the need for production of more palatable paediatric formulations of flucloxacillin.…”

Section: Resultsmentioning

confidence: 99%

“…reported a delay in the absorption of flucloxacillin and 50% overall reduction in the concentrations obtained following dosing adults in the fed state compared to the fasting state. Bergdahl et al . conducted a study in children that compared the absorption of flucloxacillin in the fed and fasted state; the results did not show significant differences in the overall exposure (of the drug as a result of food in those aged 0.5–4 years, however, there appeared to be a significant ( P < 0.05) increase in the exposure in those aged 0–1 months in the presence of food) as well as a delay in the T max .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A mixed methods study of the administration of flucloxacillin oral liquid; identifying strategies to overcome administration issues of medicines with poor palatability

Rouse

Mistry

Rayner

et al. 2017

International Journal of Pharmacy Practice

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A mixed methods study of the administration of flucloxacillin oral liquid; identifying strategies to overcome administration issues of medicines with poor palatability

Rouse

Mistry

Rayner

et al. 2017

International Journal of Pharmacy Practice

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“…Oral penicillin was characterized by a lower C max value compared with penicillin administered intramuscularly [ 68 ]. Studies revealed a better absorption of oral flucloxacillin in infants 0–1 month old compared with older children [ 69 ], especially for such formulations as mixtures [ 70 ], plasma concentrations after both intravenous (i.v.) and oral administration were well above the MIC -values generally reported for Staphylococcus aureus [ 71 ].…”

Section: General Considerations On Neonate’s Pharmacokineticsmentioning

confidence: 99%

Developmental Pharmacokinetics of Antibiotics Used in Neonatal ICU: Focus on Preterm Infants

et al. 2023

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Neonatal Infections are among the most common reasons for admission to the intensive care unit. Neonatal sepsis (NS) significantly contributes to mortality rates. Empiric antibiotic therapy of NS recommended by current international guidelines includes benzylpenicillin, ampicillin/amoxicillin, and aminoglycosides (gentamicin). The rise of antibacterial resistance precipitates the growth of the use of antibiotics of the Watch (second, third, and fourth generations of cephalosporines, carbapenems, macrolides, glycopeptides, rifamycins, fluoroquinolones) and Reserve groups (fifth generation of cephalosporines, oxazolidinones, lipoglycopeptides, fosfomycin), which are associated with a less clinical experience and higher risks of toxic reactions. A proper dosing regimen is essential for effective and safe antibiotic therapy, but its choice in neonates is complicated with high variability in the maturation of organ systems affecting drug absorption, distribution, metabolism, and excretion. Changes in antibiotic pharmacokinetic parameters result in altered efficacy and safety. Population pharmacokinetics can help to prognosis outcomes of antibiotic therapy, but it should be considered that the neonatal population is heterogeneous, and this heterogeneity is mainly determined by gestational and postnatal age. Preterm neonates are common in clinical practice, and due to the different physiology compared to the full terms, constitute a specific neonatal subpopulation. The objective of this review is to summarize the evidence about the developmental changes (specific for preterm and full-term infants, separately) of pharmacokinetic parameters of antibiotics used in neonatal intensive care units.

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“…However, neonates had higher absorption than older children, 25 and infants aged under six months had better absorption than older children with liquid formulations. 26 Higher doses and weight-based doses that are recommended in many guidelines for bone infections in children are not included in the product information.…”

Section: Flucloxacillinmentioning

confidence: 99%

Penicillin: getting prescribing right for children

Mostaghim¹,

McMullan²,

Rowles³

2020

Aust Prescr

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Penicillins are commonly prescribed to children. Recommendations in the product information may not be the most appropriate doses for children and may list clinical indications that are preferably treated with other antibiotics. Reputable guidelines, for example Therapeutic Guidelines: Antibiotic, offer up-to-date advice on optimal choice, route, dosage and duration of oral penicillins in children. In most instances, the child's weight should be used to calculate the dose in mg per kg without exceeding the maximum adult dose. When prescribing higher weight-based doses of amoxicillin or flucloxacillin, check the volume of oral liquid required to complete a treatment course to ensure adequate supply. be the most appropriate doses for children (see Box). It may only include indications and doses approved by the Therapeutic Goods Administration at registration. As most oral penicillin products in Australia have been used for more than 20 years and are generally off-patent, up-to-date dosing information may not be included in the product information, particularly for children. Prescribing in children Many childhood infections do not require antibiotics at all, including: • common self-limiting infections • viral infections • bacterial infections that require drainage or other physical treatment (e.g. cutaneous abscess, dental infections requiring timely dental treatment).

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Oral Absorption of Flucloxacillin in Infants and Young Children

Cited by 9 publications

References 11 publications

A mixed methods study of the administration of flucloxacillin oral liquid; identifying strategies to overcome administration issues of medicines with poor palatability

A mixed methods study of the administration of flucloxacillin oral liquid; identifying strategies to overcome administration issues of medicines with poor palatability

Developmental Pharmacokinetics of Antibiotics Used in Neonatal ICU: Focus on Preterm Infants

Penicillin: getting prescribing right for children

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