OR078 The prevalence of childhood food allergy in the United States: an update

Gupta, R.; Warren, C.; Blumenstock, Jesse; Kotowska, J.; Mittal, Kundan; Smith, B.

doi:10.1016/j.anai.2017.08.060

Cited by 8 publications

(7 citation statements)

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“…Accidental exposure is common in children with peanut allergies, with annual incidence of 12-15% in these children [67]. There has been an increase in peanut allergies, with a 21% increase since 2010, with 2.5% of children in the U.S. having a peanut allergy [68]. Because of this and the severity of the reaction, peanut oral immunotherapy interventions have been developed [69].…”

Section: Peanutmentioning

confidence: 99%

The Gut Microbiome and the Big Eight

et al. 2020

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Food allergies are increasing at an alarming rate, with 6.5% of the general population affected. It has been hypothesized that the increase in allergies stems from the “hygiene hypothesis”. The gut microbiome, a collection of microbiota and their genetic contents from the gastrointestinal tract, has been shown to play a part in the development of food allergies. The Food and Drug Administration requires all regulated food companies to clearly state an inclusion of the major, or “big eight” food allergens on packaging. This review is to provide information on the significant advancements related to the gut microbiome and each of the eight major food allergies individually. Establishment of causal connection between the microbiome and food allergies has uncovered novel mechanisms. New strategies are discussed to prevent future sensitization and reaction through novel treatments involving functional additives and dietary changes that target the microbiome.

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Section: Peanutmentioning

confidence: 99%

The Gut Microbiome and the Big Eight

et al. 2020

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“…In 2010, they were estimated to affect 1.68% and 1.59% of the Canadian population and 1.1% and 1.4%, of the United States population, respectively [ 3 , 4 ]. A more recent survey conducted between 2015 and 2016 estimates the prevalence of peanut allergies in children in the United States to be 2.5% [ 5 ], while Weinberger and Sicherer [ 2 ] reported an estimated tree nut prevalence varying between ~0.05% and 7.3%.…”

Section: Introductionmentioning

confidence: 99%

Immunoglobulin E-Binding Pattern of Canadian Peanut Allergic Children and Cross-Reactivity with Almond, Hazelnut and Pistachio

et al. 2020

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Peanut allergic individuals can be both co-sensitized and co-allergic to peanut and tree nuts. At the moment, standard diagnostic approaches do not always allow differentiation between clinically relevant sensitization and nonsignificant cross-reactions, and the responsibility of each allergen remains unclear. The objective of this study was therefore to determine a peanut sensitization profile in a cohort of Canadian peanut allergic children and assess the immunoglobulin E (IgE) molecular cross-reactivity between peanut, almond, hazelnut and pistachio. The specific IgE (sIgE) levels of each patient serum were determined by ImmunoCAP, indirect ELISA and immunoblot to examine their sIgE-binding levels and profiles to peanut proteins. Reciprocal inhibition ELISA and immunoblotting were used to study sIgE cross-reactions between peanut and the selected tree nuts using an adjusted and representative serum pool of the nine allergic patients. The results showed that the prepared peanut and tree nut protein extracts allowed for the detection of the majority of peanut and selected tree nut known allergens. The reciprocal inhibition ELISA experiments showed limited sIgE cross-reactivities between peanut and the studied tree nuts, with peanut being most likely the sensitizing allergen and tree nuts the cross-reactive ones. In the case of hazelnut and pistachio, a coexisting primary sensitization to hazelnut and pistachio was also demonstrated in the serum pool. Reciprocal inhibition immunoblotting further revealed that storage proteins (2S albumin, 7S vicilin and 11S legumin) could possibly account for the observed IgE-cross-reactions between peanut and the studied tree nuts in this cohort of allergic individuals. It also demonstrated the importance of conformational epitopes in the exhibited cross-reactions.

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“…Recent data from Northwestern University showed that 10.8% of adults in the US have a food allergy, with 48% of those developing at least one such allergy as an adult [ 17 ]. According to research from the American College of Allergy, Asthma and Immunology, peanut allergy in children increased by 21 percent from 2010 to 2017 [ 18 ]. In a 2016 New Jersey Monthly article, Joanna Buffum outlined the ways in which the increase in food allergies among children has changed the public school experience.…”

Section: Immunologic Disease and Climate Change: Is There A Deepermentioning

confidence: 99%

Climate Change and Human Health: A Review of Allergies, Autoimmunity and the Microbiome

Ray

Ming

2020

IJERPH

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The impact of climate change on human health is a topic of critical importance. While only recently beginning to gain attention, it is clear that immediate action is necessary to minimize this impact. In our review, we will outline a subset of these effects in detail. We will examine how climate change has worsened respiratory allergic disease. We will discuss how climate change has altered antigen exposure, possibly disrupting antigen-specific tolerance by the immune system, leading, in turn, to an increase in the prevalence of immunologic diseases. Finally, we will explore how the loss of biodiversity related to climate change may affect the microbiome, potentially leading to dysbiosis, inflammatory, autoimmune and neurologic diseases.

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OR078 The prevalence of childhood food allergy in the United States: an update

Cited by 8 publications

References 0 publications

The Gut Microbiome and the Big Eight

The Gut Microbiome and the Big Eight

Immunoglobulin E-Binding Pattern of Canadian Peanut Allergic Children and Cross-Reactivity with Almond, Hazelnut and Pistachio

Climate Change and Human Health: A Review of Allergies, Autoimmunity and the Microbiome

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