Optogenetic activation of granule cells in the dorsal dentate gyrus enhances dopaminergic neurotransmission in the Nucleus Accumbens

Tritschler, Laurent; Kheirbek, Mazen A.; Dantec, Yannick Le; Mendez‐David, Indira; Guilloux, Jean‐Philippe; Faye, Charlène; Doan, Julie; Pham, Thu Ha; Hen, René; David, Denis J.; Gardier, Alain M.

doi:10.1016/j.neures.2017.12.002

Cited by 11 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent in vitro studies using optogenetic stimulation and fast-scan cyclic voltammetry (FSCV) show that local DA signals can be triggered in the striatum by stimulation of glutamatergic inputs from thalamus (Threlfell et al, 2012;Kosillo et al, 2016;Johnson et al, 2017;Cover et al, 2019), motor cortex (Kosillo et al, 2016), or PFC (Mateo et al, 2017). These findings agree with previous literature showing in vivo DA signals in the striatum evoked by stimulation of PFC (Taber and Fibiger, 1993;Quiroz et al, 2016;Hill et al, 2018), hippocampus (Tritschler et al, 2018), or amygdala (Floresco et al, 1998). Furthermore, in vivo intrastriatal administration of glutamate and ACh was also shown to cause increases in extracellular DA concentration in the rat striatum (Giorguieff et al, 1976(Giorguieff et al, , 1977Leviel et al, 1990;Shimizu et al, 1990).…”

Section: Introductionsupporting

confidence: 90%

Prefrontal Cortex-Driven Dopamine Signals in the Striatum Show Unique Spatial and Pharmacological Properties

et al. 2020

View full text Add to dashboard Cite

Dopamine (DA) signals in the striatum are critical for a variety of vital processes, including motivation, motor learning, and reinforcement learning. Striatal DA signals can be evoked by direct activation of inputs from midbrain DA neurons (DANs) as well as cortical and thalamic inputs to the striatum. In this study, we show that in vivo optogenetic stimulation of prelimbic (PrL) and infralimbic (IL) cortical afferents to the striatum triggers an increase in extracellular DA concentration, which coincides with elevation of striatal acetylcholine (ACh) levels. This increase is blocked by a nicotinic ACh receptor (nAChR) antagonist. Using single or dual optogenetic stimulation in brain slices from male and female mice, we compared the properties of these PrL/IL-evoked DA signals with those evoked by stimulation from midbrain DAN axonal projections. PrL/IL-evoked DA signals are undistinguishable from DAN evoked DA signals in their amplitudes and electrochemical properties. However, PrL/IL-evoked DA signals are spatially restricted and preferentially recorded in the dorsomedial striatum. PrL/IL-evoked DA signals also differ in their pharmacological properties, requiring activation of glutamate and nicotinic ACh receptors. Thus, both in vivo and in vitro results indicate that cortical evoked DA signals rely on recruitment of cholinergic interneurons, which renders DA signals less able to summate during trains of stimulation and more sensitive to both cholinergic drugs and temperature. In conclusion, cortical and midbrain inputs to the striatum evoke DA signals with unique spatial and pharmacological properties that likely shape their functional roles and behavioral relevance.

show abstract

Section: Introductionsupporting

confidence: 90%

Prefrontal Cortex-Driven Dopamine Signals in the Striatum Show Unique Spatial and Pharmacological Properties

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In fact, inhibition of the dopaminergic transmission induces a fall in consumption of sucrose 58‐60 and increases in DA lead to increase in sucrose intake 59,61 . Rewarding substances stimulate the ventral tegmental area (VTA) which in turn releases DA in the accumbens, 59,62‐64 and, the hippocampus‐accumbens axis plays also a role in the DA function in the accumbens 65 . Further studies are needed to determine the implication of the hippocampus‐accumbens axis in behavioral dysfunctions we observed.…”

Section: Discussionmentioning

confidence: 87%

Spatial reference learning deficits in absence of dysfunctional working memory in the TgF344‐AD rat model of Alzheimer's disease

Tournier

Barca

Fall

et al. 2020

Genes Brain and Behavior

View full text Add to dashboard Cite

Alzheimer's disease (AD) is characterized by cognitive disorders and alterations of behavioral traits such as anhedonia and anxiety. Contribution of nonphysiological forms of amyloid and tau peptides to the onset of neurological dysfunctions remains unclear because most preclinical models only present one of those pathological AD‐related biomarkers. A more recently developed model, the TgF344‐AD rat has the advantage of overexpressing amyloid and naturally developing tauopathy, thus making it close to human familial forms of AD. We showed the presence of a learning dysfunction in a reference memory test, without spatial working memory impairment but with an increase in anxiety levels and a decrease in motivation to participate in the test. In the sucrose preference test, TgF344‐AD rats did not show signs of anhedonia but did not increase the volume of liquid consumed when the water was replaced by sucrose solution. These behavioral phenomena were observed at an age when tau accumulation are absent, and where amyloid deposits are predominant in the hippocampus and the entorhinal cortex. Within the hippocampus itself, amyloid accumulation is heterogenous between the subiculum, the dorsal hippocampus and the ventral hippocampus. Thus, our data demonstrated heterogeneity in the appearance of various behavioral and neurochemical markers in the TgF344‐AD rat. This multivariate analysis will therefore make it possible to define the stage of the pathology, to measure its evolution and the effects of future therapeutic treatments.

show abstract

“…Neuroanatomical links connect the VTA to the hippocampus and the hippocampus to the accumbens, which implies a strong interconnectivity between the hippocampus and the DA system. For example, hippocampal activity has been shown to influence DA release in the striatum 64 and addiction-related behaviours. 65 It is interesting to note that the functional DA changes observed here are present at an age when the hippocampus showed TSPO increases and amyloid accumulation.…”

Section: Discussionmentioning

confidence: 99%

Alterations in dopamine system and in its connectivity with serotonin in a rat model of Alzheimer’s disease

Ceyzériat

Gloria

Tsartsalis

et al. 2021

Brain Communications

View full text Add to dashboard Cite

Dopamine (DA) pathways alterations are reported in Alzheimer’s disease (AD). However, it is difficult in humans to establish when these deficits appear and their impact in the course of Alzheimer’s disease. In the TgF344-AD rat model at the age of 6 months, we showed a reduction in in vivo release of striatal DA due to serotonin 5HT2A-receptor (5HT2AR) blockade, in the absence of alterations in 5HT2AR binding, suggesting a reduction in 5HT2AR-DA system connectivity. In addition, a functional hypersensitivity of postsynaptic DA D2-receptors (D2R) and D2-autoreceptors was also reported without any change in D2R density and in the absence of amyloid plaques or overexpression of the 18 kDa translocator protein (TSPO, an inflammatory marker) in areas of the DA system. Citalopram, a selective serotonin reuptake inhibitor, induced functional 5HT2AR-D2R connectivity changes but had no effect on D2-autoreceptor hypersensitivity. In older rats, DA cell bodies overexpressed TSPO and DA projection sites accumulated amyloid. Interestingly, the 5HT2AR density is decreased in the accumbens subdivisions and the substantia nigra pars compacta. This reduction in the striatum is related to the astrocytic expression of 5HT2AR. Our results indicate that both serotonin/dopamine connectivity and DA signaling pathways are dysregulated and potentially represent novel early diagnostic and therapeutic avenues.

show abstract

Optogenetic activation of granule cells in the dorsal dentate gyrus enhances dopaminergic neurotransmission in the Nucleus Accumbens

Cited by 11 publications

References 25 publications

Prefrontal Cortex-Driven Dopamine Signals in the Striatum Show Unique Spatial and Pharmacological Properties

Prefrontal Cortex-Driven Dopamine Signals in the Striatum Show Unique Spatial and Pharmacological Properties

Spatial reference learning deficits in absence of dysfunctional working memory in the TgF344‐AD rat model of Alzheimer's disease

Alterations in dopamine system and in its connectivity with serotonin in a rat model of Alzheimer’s disease

Contact Info

Product

Resources

About