Prefrontal Cortex-Driven Dopamine Signals in the Striatum Show Unique Spatial and Pharmacological Properties

Adrover, Martín Federico; Shin, Jung Hoon; Quiroz, César; Ferré, Sergi; Lemos, Julia C.; Alvarez, Veronica A.

doi:10.1523/jneurosci.1327-20.2020

Cited by 27 publications

(16 citation statements)

References 48 publications

(88 reference statements)

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“…Moreover, the interactions between ChIs, cortico‐, thalamo‐, and nigro‐striatal afferents appear to be reciprocal (Fig. 1), 120‐124 further supporting the view that ChIs serve as an essential striatal integrator that orchestrates complex movements and error‐triggered corrections 125‐128 …”

Section: Attentional–motor Integration In the Striatum: Chis As Essenmentioning

confidence: 64%

“…119 Moreover, the interactions between ChIs, cortico-, thalamo-, and nigro-striatal afferents appear to be reciprocal ( Fig. 1), [120][121][122][123][124] further supporting the view that ChIs serve as an essential striatal integrator that orchestrates complex movements and errortriggered corrections. [125][126][127][128] A recent series of experiments were designed to test the general hypothesis that ChIs are essential attentional-motor integrators.…”

Section: Attentional-motor Integration In the Striatum: Chis As Essenmentioning

confidence: 64%

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Make a Left Turn: Cortico‐Striatal Circuitry Mediating the Attentional Control of Complex Movements

et al. 2021

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A BS TRACT: Background: In movement disorders such as Parkinson's disease (PD), cholinergic signaling is disrupted by the loss of basal forebrain cholinergic neurons, as well as aberrant activity in striatal cholinergic interneurons (ChIs). Several lines of evidence suggest that gait imbalance, a key disabling symptom of PD, may be driven by alterations in high-level frontal cortical and cortico-striatal processing more typically associated with cognitive dysfunction. Methods: Here we describe the corticostriatal circuitry that mediates the cognitive-motor interactions underlying such complex movement control. The ability to navigate dynamic, obstacle-rich environments requires the continuous integration of information about the environment with movement selection and sequencing. The corticalattentional processing of extero-and interoceptive cues requires modulation by cholinergic activity to guide striatal movement control. Cue-derived information is "transferred" to striatal circuitry primarily via frontostriatal glutamatergic projections. Result: Evidence from parkinsonian fallers and from a rodent model reproducing the dual cholinergicdopaminergic losses observed in these patients supports the main hypotheses derived from this neuronal circuitryguided conceptualization of parkinsonian falls. Furthermore, in the striatum, ChIs constitute a particularly critical node for the integration of cortical with midbrain dopaminergic afferents and thus for cues to control movements. Conclusion: Procholinergic treatments that enhance or rescue cortical and striatal mechanisms may improve complex movement control in parkinsonian fallers and perhaps also in older persons suffering from gait disorders and a propensity for falls.

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Section: Attentional–motor Integration In the Striatum: Chis As Essenmentioning

confidence: 64%

Section: Attentional-motor Integration In the Striatum: Chis As Essenmentioning

confidence: 64%

Make a Left Turn: Cortico‐Striatal Circuitry Mediating the Attentional Control of Complex Movements

et al. 2021

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“…In agreement with previous findings ( Noble, 2003 ; Neville et al, 2004 ; Klein et al, 2007 ; Savitz et al, 2013 ), adult ankk1 27 ins/ 27ins mutant fish showed reduced expression of drd2 protein in the pallium and subpallium. The zebrafish subpallium corresponds to the striatum of mammals, which has been shown to be involved in processes such as motor learning ( Adrover et al, 2020 ). We also observed absence of drd2 protein in the hypothalamus of ankk1 27ins/27ins .…”

Section: Discussionmentioning

confidence: 99%

Ankk1 Loss of Function Disrupts Dopaminergic Pathways in Zebrafish

et al. 2022

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Ankyrin repeat and kinase domain containing 1 (ANKK1) is a member of the receptor-interacting protein serine/threonine kinase family, known to be involved in cell proliferation, differentiation and activation of transcription factors. Genetic variation within the ANKK1 locus is suggested to play a role in vulnerability to addictions. However, ANKK1 mechanism of action is still poorly understood. It has been suggested that ANKK1 may affect the development and/or functioning of dopaminergic pathways. To test this hypothesis, we generated a CRISPR-Cas9 loss of function ankk1 zebrafish line causing a 27 bp insertion that disrupts the ankk1 sequence introducing an early stop codon. We found that ankk1 transcript levels were significantly lower in ankk1 mutant (ankk127ins) fish compared to their wild type (ankk1+/+) siblings. In ankk1+/+ adult zebrafish brain, ankk1 protein was detected in isocortex, hippocampus, basolateral amygdala, mesencephalon, and cerebellum, resembling the mammalian distribution pattern. In contrast, ankk1 protein was reduced in the brain of ankk127ins/27ins fish. Quantitative polymerase chain reaction analysis revealed an increase in expression of drd2b mRNA in ankk127ins at both larval and adult stages. In ankk1+/+ adult zebrafish brain, drd2 protein was detected in cerebral cortex, cerebellum, hippocampus, and caudate homolog regions, resembling the pattern in humans. In contrast, drd2 expression was reduced in cortical regions of ankk127ins/27ins being predominantly found in the hindbrain. No differences in the number of cell bodies or axonal projections detected by anti-tyrosine hydroxylase immunostaining on 3 days post fertilization (dpf) larvae were found. Behavioral analysis revealed altered sensitivity to effects of both amisulpride and apomorphine on locomotion and startle habituation, consistent with a broad loss of both pre and post synaptic receptors. Ankk127ins mutants showed reduced sensitivity to the effect of the selective dopamine receptor antagonist amisulpride on locomotor responses to acoustic startle and were differentially sensitive to the effects of the non-selective dopamine agonist apomorphine on both locomotion and habituation. Taken together, our findings strengthen the hypothesis of a functional relationship between ANKK1 and DRD2, supporting a role for ANKK1 in the maintenance and/or functioning of dopaminergic pathways. Further work is needed to disentangle ANKK1’s role at different developmental stages.

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“…Substantial evidence indicates that PFC can regulate attention and working memory by modulating memory-related activity within the PFC [ 45 – 47 ]. The striatum is richly innervated by midbrain DA neurons, which regulate a range of cellular and synaptic functions that control goal-directed behavior and habits [ 48 , 49 ]. The hippocampus serves a key function in memory, navigation, and cognition [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

An Shen Ding Zhi Ling Ameliorates the Symptoms of Attention Deficit Hyperactivity Disorder via Modulating Brain-Derived Neurotrophic Factor-Related Signaling Pathways

Huang

Song

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Attention deficit hyperactivity disorder (ADHD) is a common childhood neurodevelopmental disorder. It may impact the cognitive and social functions throughout childhood and determine adult outcomes. Dopamine (DA) deficiency theory is the pathogenesis of ADHD that is recognized by most international literature. Existing studies have shown that DA deficiency is caused by the abnormal function of the DA transporter and an imbalance in the DA receptor functionality. Recent clinical and experimental studies have found that the brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB) signaling pathway acts a pivotal part in DA vesicle circulation and ADHD pathogenesis. An Shen Ding Zhi Ling (ASDZL) is a traditional Chinese medicine (TCM) prescription, which was widely prescribed to treat ADHD in Jiangsu, China, but its therapeutic mechanism is unclear. Therefore, we constructed a spontaneously hypertensive rat (SHR) model to explain its mechanism. SHRs were randomly assigned to four groups: SHR model group (vehicle), methylphenidate hydrochloride group (MPH), ASDZL group, and 7,8-dihydroxyflavone group (7,8-DHF). At the same time, the above groups were given continuous medication for four weeks. The results show that ASDZL, MPH, and 7,8-DHF group could significantly improve the spatial memory of SHRs in the Morris water maze tests. ASDZL increased the levels of BDNF, TrkB, p75 neurotrophin receptor (p75), C-Jun N-terminal kinases 1 (JNK1), and nuclear factor kappa B (NF-κB) in the prefrontal cortex (PFC) and hippocampus synaptosome of SHRs. The results of this study suggest that ASDZL can relieve the symptoms of ADHD in SHRs by regulating the balance between the BDNF/TrkB signaling pathway (promoting vesicle circulation) and the BDNF/P75/JNK1/NF-κB signaling pathway (inhibiting vesicle circulation) within the PFC and hippocampus synaptosome to increase the DA concentration in the synaptic cleft. The BDNF/TrkB signal pathway within the PFC and hippocampus synaptosome was activated by 7,8-DHF to increase DA concentration in the synaptic cleft. Whether 7,8-DHF can activate or inhibit the BDNF/P75 signaling pathway remains unclear.

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Prefrontal Cortex-Driven Dopamine Signals in the Striatum Show Unique Spatial and Pharmacological Properties

Cited by 27 publications

References 48 publications

Make a Left Turn: Cortico‐Striatal Circuitry Mediating the Attentional Control of Complex Movements

Make a Left Turn: Cortico‐Striatal Circuitry Mediating the Attentional Control of Complex Movements

Ankk1 Loss of Function Disrupts Dopaminergic Pathways in Zebrafish

An Shen Ding Zhi Ling Ameliorates the Symptoms of Attention Deficit Hyperactivity Disorder via Modulating Brain-Derived Neurotrophic Factor-Related Signaling Pathways

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