Optofluidic opportunities in global health, food, water and energy

Chen, Yih Fan; Jiang, Li; Mancuso, Matthew; Jain, Anurag; Oncescu, Vlad; Erickson, David

doi:10.1039/c2nr30859b

Cited by 67 publications

(48 citation statements)

References 222 publications

(249 reference statements)

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“…Conversely, the implementation of optical trapping setups using optical fibers enables miniaturization and low cost systems. Optical fiber tweezers (OFTs) can be integrated in small devices such as optofluidic platforms or catheters introducing the extra versatility needed for more challenging applications in medical and biological environments [17].…”

Section: Introductionmentioning

confidence: 99%

New Trends on Optical Fiber Tweezers

Ribeiro

Soppera

Oliva

et al. 2015

J. Lightwave Technol.

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In the last decades Optical Trapping has played an unique role concerning contactless trapping and manipulation of biological specimens. More recently, Optical Fiber Tweezers (OFTs) are emerging as a desirable alternative to bulk optical systems. In this work an overview of the state of the art of OFTs is presented, focusing on the main fabrication methods, their features and main achievements. In addition, new OFTs fabricated by guided wave photo polymerization are reported. Their theoretical and experimental characterization is given and results demonstrating its application in the manipulation of yeast cells and the organelles of plant cells are presented.

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Section: Introductionmentioning

confidence: 99%

New Trends on Optical Fiber Tweezers

Ribeiro

Soppera

Oliva

et al. 2015

J. Lightwave Technol.

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“…P lasmonic systems are drawing much attention due to their broad applications in several fields such as biology 1 , sensing 2 , nanoscale heating 3 , nonlinear optics 4,5 , optofluidics [6][7][8] and optical trapping [9][10][11][12][13][14] . Indeed, light-absorbing nanotextured surfaces such as those utilizing metal pads, dipole antennas and bowtie nanoantennas have recently been shown to be very effective for optical manipulation 9,13,15 .…”

mentioning

confidence: 99%

Understanding and controlling plasmon-induced convection

et al. 2014

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The heat generation and fluid convection induced by plasmonic nanostructures is attractive for optofluidic applications. However, previously published theoretical studies predict only nanometre per second fluid velocities that are inadequate for microscale mass transport. Here we show both theoretically and experimentally that an array of plasmonic nanoantennas coupled to an optically absorptive indium-tin-oxide (ITO) substrate can generate 4micro-metre per second fluid convection. Crucially, the ITO distributes thermal energy created by the nanoantennas generating an order of magnitude increase in convection velocities compared with nanoantennas on a SiO 2 base layer. In addition, the plasmonic array alters absorption in the ITO, causing a deviation from Beer-Lambert absorption that results in an optimum ITO thickness for a given system. This work elucidates the role of convection in plasmonic optical trapping and particle assembly, and opens up new avenues for controlling fluid and mass transport on the micro-and nanoscale.

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“…With recent advancements in the field of optofluidics19, sunlight is finding a number of novel applications in both energy2021 and global health22. Here we create solar thermal PCR, which eliminates the energy burden for nucleic acid amplification by employing sunlight to perform thermal cycling.…”

Section: Resultsmentioning

confidence: 99%

Solar thermal polymerase chain reaction for smartphone-assisted molecular diagnostics

Jiang

Mancuso

et al. 2014

Sci Rep

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Nucleic acid-based diagnostic techniques such as polymerase chain reaction (PCR) are used extensively in medical diagnostics due to their high sensitivity, specificity and quantification capability. In settings with limited infrastructure and unreliable electricity, however, access to such devices is often limited due to the highly specialized and energy-intensive nature of the thermal cycling process required for nucleic acid amplification. Here we integrate solar heating with microfluidics to eliminate thermal cycling power requirements as well as create a simple device infrastructure for PCR. Tests are completed in less than 30 min, and power consumption is reduced to 80 mW, enabling a standard 5.5 Wh iPhone battery to provide 70 h of power to this system. Additionally, we demonstrate a complete sample-to-answer diagnostic strategy by analyzing human skin biopsies infected with Kaposi's Sarcoma herpesvirus (KSHV/HHV-8) through the combination of solar thermal PCR, HotSHOT DNA extraction and smartphone-based fluorescence detection. We believe that exploiting the ubiquity of solar thermal energy as demonstrated here could facilitate broad availability of nucleic acid-based diagnostics in resource-limited areas.

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Optofluidic opportunities in global health, food, water and energy

Cited by 67 publications

References 222 publications

New Trends on Optical Fiber Tweezers

New Trends on Optical Fiber Tweezers

Understanding and controlling plasmon-induced convection

Solar thermal polymerase chain reaction for smartphone-assisted molecular diagnostics

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