Optofluidic Immunosensor Based on Resonant Wavelength Shift of a Hollow Core Fiber for Ultratrace Detection of Carcinogenic Benzo[a]pyrene

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are always regarded as contaminants originating from the incomplete combustion of organic compounds. Benzo[a]pyrene (B[a]P) can be adopted as a marker for the overall PAH mixture due to its ultratoxic property, which can cause cancer of the lungs, skin, and prostate. It is necessary to monitor the B[a]P contamination levels in a water environment. In this article, an in-line fiber optofluidic sensor for the detection of B[a]P in water by using an antiresonant reflecting optical waveguide is proposed and experimentally demonstrated. One air hole in the cladding of the hollow-core fiber was fabricated as an in-line fiber optofluidic combined with two inlet and outlet microchannels fabricated by using femtosecond laser micromachining. The B[a]P molecule can be detected through the antiresonant reflecting optical waveguide due to the immunoreaction between the antibody and the target B[a]P. The experimental results show that a sensitivity of up to 23 pm/pM is achieved. The proposed fiber sensor appears to have potential applications in research on environmental contamination, food safety, human health, etc.

Recent Advancement of Anti-Resonant Hollow-Core Fibers for Sensing Applications

“…On the one hand, they have appropriate transmission loss values that can be satisfied in most sensing application scenarios [33][34][35][36][37][38][39]. On the other hand, their distinct advantage is that they can offer a versatile multichannel and lab-on-a-fiber platform [40][41][42][43][44][45]. As a consequence, the following sections will emphasize the novel and advanced sensing applications based on the most common AR-HCFs at present.…”

A fiber optic–nanophotonic approach to the detection of antibodies and viral particles of COVID-19

“…The use of light transmission is a very sensitive tool for the detection of antibodies and can work even without the use of labels [15][16][17][18][19][20]. This technique has the capability of detecting a single nanoparticle of about 20 nm as demonstrated by Lan Yang et al [15,21].…”

Antiresonant Reflecting Guidance and Mach-Zender Interference in Cascaded Hollow-Core Fibers for Multi-Parameter Sensing

“…The development of hollow core fibers (HCFs) based on antiresonant reflecting guidance (ARRG) has produced a variety of novel fiber devices in recent years [1,2,3,4,5]. The interior hollow core of ARRG fibers allows them to be filled with functional fluids [6,7,8,9,10] and the extramural cladding enables coating with functional films for various sensing applications [11,12,13]. We previously used a section of HCF as a micro-channel for air pressure sensing [14].…”