Optische Rehabilitation nach Limbusstammzellinsuffizienz: aktuelle Behandlungsmöglichkeiten und Entwicklungen

Abstract

Limbal stem cell deficiency (LSCD) is a condition caused by the loss of corneal epithelial regenerative potential. The treatment of this condition is still a challenge. It results from various conditions both intrinsic as well as extrinsic. LSCD can be either uni- or bilateral and either partial or total. Today treatment options include a variety of techniques including transplantation of amniotic membrane and limbal tissue or tissue engineered cell sheets. This article summarizes the current techniques to treat LSCD and upcoming developments.

Novel Animal Model of Limbal Stem Cell Deficiency Induced by Forcing Eye-Open at Birth

“…Limbal stem cell deficiency (LSCD) is manifested by chronic inflammation and vascularization, resulting in conjunctival scarring in the cornea and loss of visual acuity. 3 The therapeutic strategies for these diseases involve 2 major approaches: one is transplantation of the tissue from the contralateral healthy limbus (autograft) 4,5 or from donors (allograft), 6,7 and the other is regeneration of the sheets of corneal limbus tissue in vitro. 8,9 Despite enormous progress during the last decade in corneal epithelial bioengineering, much is left to be learned regarding the fundamental molecular characterization of limbal epithelial stem cells (LSCs) and their progeny.…”