“…Biophysical techniques are used (i) to assess treatments of dermatological disorders (9), (ii) to evaluate the clinical severity of either distinct skin diseases (10–12) or a single symptom such as dryness (13), (iii) to quantify experimentally induced irritation (7, 14, 15), and finally (iv) to assess the efficacy of skin protective means (e.g. gloves and moisturizers) (16–20). Moreover, the measurement of transepidermal water loss (TEWL) as an indicator of skin barrier function and colorimetry for quantifying erythema has been recommended for monitoring persons at risk of irritant occupational hand dermatitis.…”