Optimizing Scale Up Yield to Pyridazines and Fused Pyridazines

The discovery of intriguing properties shown by a large number of pyrazole derivatives has sparked a surge in interest in pyrazole chemistry over the last decade. They exist in a variety of natural products, dyes, and as scaffolds in a variety of drugs and pharmaceutical active ingredients. This review demonstrated various methods for the construction of pyrazole-fused heterocycles using pyrazole-4-carbaldehydes as effective precursors. Heterocyclic compounds mentioned in this review are arranged into categories based on the size of the heterocyclic ring as well as the position and number of the heteroatoms..

Section: Introductionmentioning

confidence: 99%

Synthesis of various pyrazole-fused heterocyclic systems using pyrazole-4-carbaldehydes as versatile precursors

Abdelhamid¹,

Hawass²,

Sanad³

et al. 2021

“…The review will cover the literature in this field from 2015-2020. A few of the recent reviews [49][50][51][52][53][54][55][56] on this subject appear not to have paid sufficient attention to fused uracil systems in an ordered manner with respect to the ring system.…”

Section: Introductionmentioning

confidence: 99%

Aminouracil and aminothiouracil as versatile precursors for a variety of heterocyclic systems

Diab¹,

Salem²,

Abdelhamid³

et al. 2021

Heterocycles, particularly pyrimidine derivatives, which are present in many natural products and many interesting synthetic compounds, are the most diverse class of organic compounds and have significant chemical, biomedical and industrial applications. Uracil, a pyrimidine derivative, constitutes a promising structure in widespread natural products and many of its derivatives exhibited significant pharmacological properties. They have been widely used as starting materials for the synthesis of a huge number of biologically important nitrogen-containing heterocycles. This review casts light on various methods for the construction of different heterocyclic systems utilizing aminouracil and aminothiouracil as versatile precursors. The heterocyclic systems mentioned in this review are categorized according to the type of the heterocyclic systems.

“…Continuing our interest in reviewing various approaches to heterocyclic system synthesis, [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] this review highlights the different synthetic methods for the preparation of pyrazole-carboxaldehydes and their usefulness as versatile precursors for different pyrazole-substituted heterocyclic systems. Based on the size of the heterocyclic ring as well as the position and number of the heteroatoms, heterocyclic compounds mentioned in this review are arranged.…”

Section: Introductionmentioning

confidence: 99%

Pyrazole-carboxaldehydes as versatile precursors for different pyrazole-substituted heterocyclic systems

Elwahy¹,

Abdelhamid²,

Hawass³

et al. 2021

In the last decade, interest in pyrazole chemistry has grown considerably due to the discovery of fascinating properties demonstrated by a large number of pyrazole derivatives. They occur in a wide range of natural products, dyes, and as scaffolds in a number of drugs and associated pharmaceutical active substances. Substantial attention has been paid to the creation of hybrid molecules in which two heterocycles are bound in a single molecule to enhance their biological effectiveness and overcome drug resistance. In this regard, this review illustrated various methods for the construction of pyrazole-substituted heterocycles and their corresponding fused derivatives using pyrazole carboxaldehydes as effective precursors. The heterocyclic systems mentioned in this review are categorized according to the type of the heterocyclic systems.