Optimizing partition-controlled drug release from electrospun core–shell fibers

Tiwari, Sandeep; Tzezana, Roey; Zussman, Eyal; Venkatraman, Subbu S.

doi:10.1016/j.ijpharm.2010.03.021

Cited by 128 publications

(92 citation statements)

References 25 publications

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“…Changing parameters such as the composition of the core and the shell, the chemical properties, as well as the injection speeds, showed profound influence on the release profiles of the delivered molecules [67] [68]. A hydrophilic core with a hydrophobic shell is a proper combination for the delivery of proteins and hydrophilic drugs.…”

Section: Single Drug Deliverymentioning

confidence: 99%

Core–shell designed scaffolds for drug delivery and tissue engineering

2015

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Section: Single Drug Deliverymentioning

confidence: 99%

Core–shell designed scaffolds for drug delivery and tissue engineering

2015

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“…For instance Sohrabi et al [50], designed a drug delivery system based on coaxial nanofibers of poly(methyl methacrylate)(PMMA)-nylon6 that contained ampicillin as a model drug. Authors observed that these systems were capable of releasing the drug in a sustained manner [51]. They also reported that a clear difference exists in the release profiles of hydrochloride metoclopramide when uniaxial fibers prepared with poly(ε-caprolactone) (PCL), poly(lactic acid) (PLA), poly(lactic-co-glycolic) (PLGA) and polyvinyl alcohol (PVA) were used and when their coaxial fibers were prepared using polyvinyl alcohol (PVA) as a core.…”

Section: Electrospinning Process and Fiber Characterizationmentioning

confidence: 99%

Electrospun nanofibers of polyCD/PMAA polymers and their potential application as drug delivery system

Oliveira

Suárez

Rocha

et al. 2015

Materials Science and Engineering: C

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Herein, we used an electrospinning process to develop highly efficacious and hydrophobic coaxial nanofibers based on poly-cyclodextrin (polyCD) associated with poly(methacrylic acid) (PMAA) that combines polymeric and supramolecular features for modulating the release of the hydrophilic drug, propranolol hydrochloride (PROP). For this purpose, polyCD was synthesized and characterized, and its biocompatibility was assessed using fibroblast cytotoxicity tests. Moreover, the interactions between the guest PROP molecule and both polyCD and βCD were found to be spontaneous. Subsequently, PROP was encapsulated in uniaxial and coaxial polyCD/ PMAA nanofibers. A lower PROP burst effect (reduction of approximately 50%) and higher modulation were observed from the coaxial than from the uniaxial fibers. Thus, the coaxial nanofibers could potentially be a useful strategy for developing a controlled release system for hydrophilic molecules.

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“…In addition, this technique does not require good interaction between the polymer and the drug but it must have sufficient interfacial compatibility to prevent delamination. 90 Recently, Han et al 91 fabricated a novel dual drug delivery system whereby the drugs were separately loaded in either the sheath or the core of the fiber (Fig. 2).…”

Section: Co-axial Electrospinningmentioning

confidence: 99%

Drug Loading and Release from Electrospun Biodegradable Nanofibers

Goonoo¹,

Bhaw‐Luximon²,

Jhurry³

2014

j biomed nanotechnol

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This review explores the potential of electrospun nanofibers for drug delivery applications. In the first section, some of the key challenges in drug delivery as well as the promise of electrospun drug loaded nanofibers are highlighted. Techniques of drug incorporation into nanofibers such as blending, surface modification and co-axial electrospinning are detailed. The major requirements of drug eluting scaffolds such as biocompatibility and biodegradability, efficient drug control and release, and adequate mechanical performance are addressed. Drug release kinetics, biodegradability and mechanical properties can be controlled by careful selection of polymers and electrospinning processing parameters while biocompatibility of electrospun mats may be enhanced through surface modification of the nanofibers. The major applications as well as the routes of administration of the drug-loaded electrospun nanostructures are discussed. Currently available drug eluting nanofibrous mats for applications ranging from cancer therapy to wound dressings as well as their preclinical trials are also reviewed.

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Optimizing partition-controlled drug release from electrospun core–shell fibers

Cited by 128 publications

References 25 publications

Core–shell designed scaffolds for drug delivery and tissue engineering

Core–shell designed scaffolds for drug delivery and tissue engineering

Electrospun nanofibers of polyCD/PMAA polymers and their potential application as drug delivery system

Drug Loading and Release from Electrospun Biodegradable Nanofibers

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