Optimizing local control in anorectal melanoma

Abstract

13of anorectal melanoma were evaluated in our institution. These patients were identified from the computer data base in our tumor registry using the ICD-O (third edition) site codes for anus and rectum (C21.0, C44.5 and C20.9) and the morphology code for melanoma (M-8720/3). The case records of these patients were retrospectively reviewed in detail to obtain information regarding clinical features (symptoms, duration, investigations and stage), pathological features (size, depth of invasion and immunohistochemical studies), treatment and follow-up details. Depth of the lesion was assessed either by histopathological examination of the surgical specimen or by clinical examination in patients who did not undergo surgery.Immunohistochemistry (IHC), performed by the streptavidin-biotin-peroxidase method was used to further categorize anorectal tumors labelled on routine Optimizing local control in anorectal melanomaRamakrishnan AS, Mahajan V, Kannan R Department of Surgical Oncology, Cancer Institute (WIA), Adyar, Chennai -600 036, Tamil Nadu, IndiaCorrespondence to: Dr. Ramakrishnan AS, E-mail: ram_a_s@yahoo.com Abstract BACKGROUND: Wide local excision (WLE) of anorectal melanoma is associated with a high incidence of local recurrence.

Anorectal malignant melanoma: Diagnosis and treatment of 42 cases

“…It was also considered to be more thorough in excision so that it had some advantages in controlling the relapse, especially for the early-stage patients [22] . Now it is generally considered that the operation type should be individualized [23] . The local wide excision should be the preferable treatment when the tumor is excisable.…”

Anal melanomas: The sun does not shine on this mucosa

“…They tend to spread sub mucosally and by the time they cause symptoms, they are often beyond surgical cure. Rectal melanomas account for less than 3% of all melanomas and are more common in females as compared to males (McLaughlin et al, 2005;Wanebo et al, 1981;Ramakrishnan et al, 2008). Once a rectal mass is noted, pigmentation is a clue for diagnosis of melanoma; however, macroscopic pigmentation is not always present.…”

“…The patients present with bleeding, diarrhea, tenesmus and severe pain on defaecation (Wanebo et al, 1981;Ramakrishnan et al, 2008). The black brown ulceroproliferative tumor is often visible and is always palpable as a nodule or induration, without or with inguinal lymphadenopathy (20%).…”

Primary malignant melanoma of anorectum: A rare entity

“…[3] The initial symptom of presentation is bleeding per rectum, and the patient may delay consultation assuming symptoms to be hemorrhoidal disease. [4,5] Surgery remains the mainstay of the treatment, but the surgical therapy is uncertain and controversial. Surgical management includes a conservative approach of wide local excision (WLE) of the tumor or a more radical approach of abdominoperineal resection (APR).…”