Optimizing donor selection in a cord blood bank

Solves, Pilar; Perales, Alfredo; Mirabet, Vicente; Blasco, I. López; Blanquer, Amando; Planelles, Dolores; Larrea, Luís; Monleón, Javier; Carbonell-Uberos, Francisco; Soler, María Rodríguez

doi:10.1046/j.0902-4441.2003.00187.x

Cited by 29 publications

(47 citation statements)

References 14 publications

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“…Thus, non-Caucasian population has a CFU-GM (colony forming units of granulo-monocytes) yield lower and poor qualitatively comparative with Caucasian one, fact demonstrated by the authors through secondary CFU-GM colonies on replating in semisolid media [5]. Another study realized at a UCB bank in Valencia (Spain), shows that there are differences between criteria that can be applied for UCB collection based on infants characteristics from a specific geographic area [1]. This could explain the differences between the existing reports and conclude that stringent universal selection criteria can not be recommended.…”

Section: Discussionmentioning

confidence: 99%

“…There are discrepancies in regards to the CD34+ number. Some authors claim that there are not significant differences between the sexes [1], and others show that male infants had a higher CD34+ cell content then female, the difference in absolute concentration being around 5.3% [12,13].…”

Section: Discussionmentioning

confidence: 99%

“…For those clinics in which UCB is harvested after placental expulsion, its weight can represent other valid obstetrical criteria for selecting efficient UCB units. Apparently there is a direct connection between newborn's weight, placental weight and UCB volume that can be collected [1,11]. Solves et al showed that if placental weight is over 700 g, an adequate volume of cord blood can be collected for preservation.…”

Section: Discussionmentioning

confidence: 99%

“…The stem cells therapeutic spectrum includes several hematological malignances and other metabolic disorders [1].…”

Section: Introductionmentioning

confidence: 99%

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Optimizing donor selection in order to establish a cord blood banking facility: maternal and obstetric factors impact

Chivu¹,

Nastasia

Sultana³

et al. 2007

Open Medicine

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AbstractIn this study, we analyzed the obstetric factors affecting total nucleated cells (TNC) content of cord blood units to establish the criteria for umbilical cord blood (UCB) donor selection in our geographic area.UCB was collected from normal uncomplicated pregnancies. In every case, following data were recorded: (1) gestation length; (2) type of delivery (cesarean or vaginal); and (3) newborn characteristics: weight and sex. For each sample, TNC content, percentage and number of CD34+ cells, and viability were analyzed.The results showed that TNC content increases with cord blood volume, gestational length and newborn weight. The mean blood volume and the mean TNC per unit were 42.37 ± 13.5 ml and 55.49 ± 19.4 × 107, respectively. Stepwise regression analysis revealed a positive and significant correlation (r= 0.89) between these two variables. Meanwhile the CD34+ cell content remains unchanged in deliveries at 32–40 weeks of gestation. The mean CD34+ percentage obtained was 0.37 ± 0.06, and the total number of CD34+ cells was 4.827 ± 0.8204 × 104 / mL UCB.Concluding, the maternal and obstetric factors have a significant impact on UCB cell quantity and quality. The main criteria for UCB collection and storage resulted to be: a gestational age higher than 36–40 weeks and newborn weight > 3200g; gestation number ≤ 2 and placental weight > 700g can be added to the standard criteria to improve the bank efficiency. Our results have also become helpful in evaluating stored UCB units to establish the adequacy for clinical transplant utilization.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The stem cells therapeutic spectrum includes several hematological malignances and other metabolic disorders [1].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Optimizing donor selection in order to establish a cord blood banking facility: maternal and obstetric factors impact

Chivu¹,

Nastasia

Sultana³

et al. 2007

Open Medicine

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show abstract

“…Birth weight, 6,7,23 length 8 and gender 4,10,17,24 have been correlated with CBU volume and TNCC; as well as different obstetric parameters, such as placenta weight, 17 time of cord clamping and time of UCB collection after birth. 17,23,25 A Canadian study showed that birth weights from different ethnic groups are significantly different, and encouraged modification of birth weight curves according to ethnicity; it is interesting to note that Middle Eastern and North African populations present the closest mean birth weight to European and Western populations.…”

Section: Discussionmentioning

confidence: 99%

Cord blood collection and banking from a population with highly diverse geographic origins increase HLA diversity in the registry and do not lower the proportion of validated cord blood units: experience of the Marseille cord blood bank

Bordoni

Magalon

Gilbertas

et al. 2015

Bone Marrow Transplant

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Several Cord Blood (CB) Bank studies suggested that ethnicity impaired CB unit (CBU) qualification. The Bone Marrow Donors Worldwide registries present an over-representation of unrelated donors (UD) from Northwestern European descent. This raises the question of equality of access to hematopoietic stem cells transplant, especially in the Mediterranean zone, which has taken in many waves of immigration. The aim of our study is to address whether, in the Marseille CB Bank, CBU qualification rate is impaired by geographic origin. The study compared biological characteristics of 106 CBU disqualified for total nucleated cell (TNC) count (dCBU) and 136 qualified CBU in relation to registry enrichment and haplotype origin. A high proportion (480%) of both dCBU and CBU had at least one non-European haplotype and enrich CB and UD registries to a higher extent than those with two European haplotypes (P o 0.001). No difference was observed between TNC count and volume according to geographic origin. Our study shows that diverse Mediterranean origins do not have an impact on the CBU qualification rate. Partnership with Mediterranean birth clinics with highly trained staff is a reasonable option to increase the HLA diversity of CB Bank inventories and to improve the representation of minorities.

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The effect of maternal and infant factors on cord blood yield

Mousavi

Abroun

Zarrabi

et al. 2016

Pediatr Blood Cancer

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Umbilical cord blood (CB) can be used as an alternative hematopoietic stem cell source for transplantation in hematological malignancy and blood disorders. The success of transplantation is highly related to the levels of total nucleated cell and CD34 cell counts. The evaluation of optimal conditions can decrease the rate of graft rejection due to low cell count and increases the quality of CB units (CBUs) in the blood bank and the success rate of engraftment. To this end, we review the maternal and infant parameters affecting the quality and quantity of CBUs.

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Optimizing donor selection in a cord blood bank

Abstract: Our study shows that maternal medical histories must be completely reviewed by medical staff before collection of the UCB. Obstetrical factors influence cell content of UCB and could be added to standard cord blood donor criteria in order to improve the bank efficiency.

Cited by 29 publications

References 14 publications

Optimizing donor selection in order to establish a cord blood banking facility: maternal and obstetric factors impact

Optimizing donor selection in order to establish a cord blood banking facility: maternal and obstetric factors impact

Cord blood collection and banking from a population with highly diverse geographic origins increase HLA diversity in the registry and do not lower the proportion of validated cord blood units: experience of the Marseille cord blood bank

The effect of maternal and infant factors on cord blood yield

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