Optimized Box–Behnken experimental design based response surface methodology and Youden’s robustness test to develop and validate methods to determine nateglinide using kinetic spectrophotometry

Haque, Sk Manirul

doi:10.1016/j.saa.2021.120712

Cited by 17 publications

(3 citation statements)

References 31 publications

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“…The evaluated parameters were the organoleptic characteristics, pH value, apparent viscosity (cP), and total flavonoid content, expressed as rutin equivalents, remaining in the samples (µg/mL) [42]. The quantification of rutin was performed through UV spectrophotometry at 361.0 nm [43][44][45]. In the storage conditions at 24.0 ± 2.0 °C and 5.0 ± 0.5 °C (refrigerator), the samples showed reduced degradation of rutin content compared to the levels determined after their preparation.…”

Section: Physicochemical Stability Of Cosmetic Preparations Containin...mentioning

confidence: 99%

“…There was a reduction of 34.16 and 35.12% in the rutin concentration for the system without and with lecithin, respectively [41]. Considering that the evaluation of the stability of emulsified systems is usually conducted empirically, the protocol used in this work has advantages by systematically establishing experimental assays and objective criteria for the acceptance/rejection of samples in a short period [42][43][44][45][46].…”

Section: Physicochemical Stability Of Cosmetic Preparations Containin...mentioning

confidence: 99%

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Would be Rutin a Feasible Strategy for Environmental-Friendly Photoprotective Samples? A Review from Stability to Skin Permeability and Efficacy in Sunscreen Systems

Ariede,

Gomez Junior,

Cândido

et al. 2024

Preprint

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Rutin, a flavonoid compound found in various plants, has gained attention for its potential applications in the cosmetic industry due to its antioxidant, anti-inflammatory, and potential photoprotective properties. Our review explored the use of rutin (rutoside, 3-O-rutinoside-quercetin) in cosmetics/dermocosmetics, focusing on its physicochemical properties and stability, cutaneous permeability, and efficacy in sunscreen systems, involving in vitro tests and the current state of clinical trials. Rutin's ability to scavenge free radicals, prevent peroxidation, and reduce vascular fragility makes this flavonoid a promising ingredient for photoprotection. Studies have shown that rutin can enhance the sun protection factor (SPF) of sunscreen formulations, especially when combined with organic UV filters. The encapsulation of rutin in nanostructures has also been investigated to improve its applicability. Overall, rutin shows potential as a safe and effective ingredient in cosmetic/dermocosmetic formulations, offering protection against the harmful effects of UV radiation and oxidative stress on the skin.

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Section: Physicochemical Stability Of Cosmetic Preparations Containin...mentioning

confidence: 99%

Section: Physicochemical Stability Of Cosmetic Preparations Containin...mentioning

confidence: 99%

Would be Rutin a Feasible Strategy for Environmental-Friendly Photoprotective Samples? A Review from Stability to Skin Permeability and Efficacy in Sunscreen Systems

Ariede,

Gomez Junior,

Cândido

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Others trials differed from each other because of the effects of its interaction over the factors. Here, optimization was performed in simultaneous drugs, considering three factors that affect the retention time and tailing factor response of each drug [22,23].…”

Section: Optimization Of Chromatographic Conditions Using Bbdmentioning

confidence: 99%

Simultaneous Estimation of Escitalopram and Clonazepam in Tablet Dosage Forms Using HPLC-DAD Method and Optimization of Chromatographic Conditions by Box-Behnken Design

et al. 2022

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The study aimed to develop a new reverse-phase high-performance liquid chromatography (RP-HPLC) method with diode array detection (DAD) detection for simultaneous estimation of escitalopram (EST) and clonazepam (CZP) in tablet dosage forms with a quality by design (QbD) approach. The chromatographic conditions were optimized by Box-Behnken design (BBD) and developed method was validated for the linearity, system suitability, accuracy, precision, robustness, sensitivity, and solution stability according to International Council for Harmonization (ICH) guidelines. EST and CZP standard drugs peaks were separated at retention times of 2.668 and 5.046 min by C-18 column with dimension of 4.6 × 100 mm length and particle size packing 2.5 µm. The mobile phase was methanol: 0.1% orthophosphoric acid (OPA) (25:75, v/v), with a flow rate of 0.7 mL/min at temperature of 26 °C. The sample volume injected was 20 µL and peaks were detected at 239 nm. Using the standard calibration curve, the % assay of marketed tablet was founded 98.89 and 98.76 for EST and CZP, respectively. The proposed RP-HPLC method was able to detect EST and CZP in the presence of their degradation products, indicating the stability-indicating property of the developed RP-HPLC method. The validation parameter’s results in terms of linearity, system suitability, accuracy, precision, robustness, sensitivity, and solution stability were in an acceptable range as per the ICH guidelines. The newly developed RP-HPLC method with QbD application is simple, accurate, time-saving, and economic.

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The Application of Box-Behnken-Design in the Optimization of Kinetic Spectrophotometry and Computational Studies to Determine and Assessing Eco-Scale to Green Analytical Chemistry for Labetalol

Haque,

Aldhafeeri,

Rahman

et al. 2024

J Pharm Innov

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Optimized Box–Behnken experimental design based response surface methodology and Youden’s robustness test to develop and validate methods to determine nateglinide using kinetic spectrophotometry

Cited by 17 publications

References 31 publications

Would be Rutin a Feasible Strategy for Environmental-Friendly Photoprotective Samples? A Review from Stability to Skin Permeability and Efficacy in Sunscreen Systems

Would be Rutin a Feasible Strategy for Environmental-Friendly Photoprotective Samples? A Review from Stability to Skin Permeability and Efficacy in Sunscreen Systems

Simultaneous Estimation of Escitalopram and Clonazepam in Tablet Dosage Forms Using HPLC-DAD Method and Optimization of Chromatographic Conditions by Box-Behnken Design

The Application of Box-Behnken-Design in the Optimization of Kinetic Spectrophotometry and Computational Studies to Determine and Assessing Eco-Scale to Green Analytical Chemistry for Labetalol

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