The Application of Box-Behnken-Design in the Optimization of Kinetic Spectrophotometry and Computational Studies to Determine and Assessing Eco-Scale to Green Analytical Chemistry for Labetalol

Haque, SK Manirul; Aldhafeeri, Thamer Nasser; Rahman, Nafisur; Jain, Rajeev; Umar, Yunusa; Siddiqui, Masoom Raza

doi:10.1007/s12247-024-09828-8

J Pharm Innov

2024

DOI: 10.1007/s12247-024-09828-8

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The Application of Box-Behnken-Design in the Optimization of Kinetic Spectrophotometry and Computational Studies to Determine and Assessing Eco-Scale to Green Analytical Chemistry for Labetalol

SK Manirul Haque,

Thamer Nasser Aldhafeeri,

Nafisur Rahman

et al.

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2024

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Cited by 2 publications

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One‐pot derivatization spectrofluorimetric method for detection of aspartame in sweetener commercial tablets and soft drinks: Greenness assessments of the methodology

AlSalem,

Alharbi,

Binkadem

et al. 2024

Luminescence

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Aspartame is an artificial sweetener used in drinks and many foods. International Agency for Research on Cancer classified aspartame as possibly carcinogenic to humans (IARC Group 2B). In this study, a sensitive and selective spectrofluorimetric method was developed to detect aspartame. The method is based on switching on the fluorescence activity of aspartame upon its condensation with O‐phthalaldehyde (Roth's reaction) in the presence of 2‐mercaptoethanol. The reaction product was detected fluorometrically at λem of 438 nm after λex of 340 nm. All reaction conditions required to yield the optimal fluorescence intensity were observed and investigated. Furthermore, the approach was validated according to ICH guidelines. Upon plotting the concentrations of aspartame against their associated fluorescence intensity values, the relationship between the two variables was linear within the range of 0.5–3.0 μg/mL. Furthermore, the method was employed to analyze the quantity of aspartame in commercial packages and soft drinks with an acceptable level of recovery. In addition, the Green Solvents Selecting Tool, Complementary Green Analytical Procedure Index, and the Analytical Greenness Metric tool were used to evaluate the sustainability and the greenness of the developed methodology.

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One‐pot derivatization spectrofluorimetric method for detection of aspartame in sweetener commercial tablets and soft drinks: Greenness assessments of the methodology

AlSalem,

Alharbi,

Binkadem

et al. 2024

Luminescence

View full text Add to dashboard Cite

show abstract

Greener spectrophotometric and HPLC investigation of CNS agent pregabalin: Taguchi model and box-behnken design for method parameters optimization

Haque,

Abu-Judeh,

Jain

et al. 2024

Journal of Molecular Structure

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The Application of Box-Behnken-Design in the Optimization of Kinetic Spectrophotometry and Computational Studies to Determine and Assessing Eco-Scale to Green Analytical Chemistry for Labetalol

Cited by 2 publications

References 54 publications

One‐pot derivatization spectrofluorimetric method for detection of aspartame in sweetener commercial tablets and soft drinks: Greenness assessments of the methodology

One‐pot derivatization spectrofluorimetric method for detection of aspartame in sweetener commercial tablets and soft drinks: Greenness assessments of the methodology

Greener spectrophotometric and HPLC investigation of CNS agent pregabalin: Taguchi model and box-behnken design for method parameters optimization

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