Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs

Shiyan, Shaum; Marketama, Misirti Maulidia Anis; Pratiwi, Galih

doi:10.12928/pharmaciana.v11i3.19935

Cited by 2 publications

(2 citation statements)

References 13 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using the cluster analysis (CA) method, the score plot results will be strengthened from the dendrogram. Multivariate analysis on the chemometric approach was supported by Minitab software (Shiyan, Marketama, et al, 2021).…”

Section: Chemometric Analysismentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Response Corellation Using Chemometrics Analysis for Pre-Optimization Quercetin – Self Emulsion Formulation

Shiyan

Pratiwi³

2022

JFSP

Self Cite

View full text Add to dashboard Cite

The optimization approach using the simplex lattice design (SCD) has many advantages, including a minimized number of experiments and a good description of the interactions between components. However, modeling with the SCD approach has not evaluated between responses. Therefore, this study aims to apply chemometric analysis to evaluate the response from the optimization stage using the quercetin – self emulsion formulations (quercetin-SEFs) as a model. SEFs were prepared using grapeseed oil, croduret, and PEG 400. The evaluated responses included emulsification time and transmittance. Both responses were developed in endurance test by centrifugation method and stability test using freeze-thaw. Chemometric analysis on CA produced a dendrogram, while PCA produced score plots, loading plots, scree plots, and biplots. Emulsification time has a positive correlation with transmittance value. The quercetin-SEFs formula in SCD was classified into three groups based on the similarity of characters. Chemometric analysis was successfully applied in evaluating the response to the quercetin-SEFs optimization modeling.

show abstract

Section: Chemometric Analysismentioning

confidence: 99%

“…Optimization procces is needed to meet the SEFs parameters. DoE is widely applied to optimization procedures for example (Pratiwi et al, 2020;Shiyan, Marketama, et al, 2021). simplex centroid design (SCD) (Maciel et al, 2020;Nunes Filho et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Response Corellation Using Chemometrics Analysis for Pre-Optimization Quercetin – Self Emulsion Formulation

Shiyan

Pratiwi³

2022

JFSP

Self Cite

View full text Add to dashboard Cite

show abstract

FTIR-ATR based fingerprinting and chemometrics analysis of metabolites profile of Phyllanthus niruri L. affected by fertilization with NPK-chitosan nanopolymer and harvesting age

Shiyan

Safitri

et al. 2022

Herba Polonica

View full text Add to dashboard Cite

Summary Introduction: Phyllanthus niruri L. (PnL) is a herbaceous plant containing flavonoid quercetin and can be used as an immunomodulator to prevent Covid-19. However, the flavonoid content and yield of herbs extract were not maximized. Therefore, PnL herbs were planted in various harvest periods and application of NPK-chitosan nanopolymer fertilizer to estimate these parameters. Objectives: Determine the effect of NPK-chitosan nanopolymer fertilizer and harvesting age on herb extracts also determine the grouping pattern and correlation between responses based on FTIR-ATR spectral pattern using a chemometric approach. Methods: Each group consisted of 50 plants. The formulation of NPK-chitosan nanopolymer fertilizer based on the dose of NPK consisting of the first dose is 15.5 grams/group, the second dose is 31 grams/group, and the third dose is 7.5 grams/group. Grouping of differences in harvesting age for plants consisted of 4, 6, and 8 weeks after the plant (WAP). Extraction used ultrasound-assisted extraction, and data were analyzed using a chemometric approach. Results: Extract with the highest yield was found in second harvest time and third doses of fertilizer (W2D3) which is 9.73 %, and the highest TFC obtained in an extract with second harvest time and first doses of fertilizer (W2D1) is 17.34 mg QE/g. Total flavonoid content and extract yield were influenced by functional groups at wavenumbers 3486.77–3157.12 cm−1 (1); 1740.96–1670.34 cm-1 (3); 1425.02–1272.62 cm-1 (5); 1257,753–1138,81 cm−1 (6); 1131.38–945.53 cm-1 (7); 711.36–529.23 cm-1 (8). Conclusions: The results showed that harvest time and fertilizer dose affected the growth parameters of PnL, total flavonoid content, and yield of extract. Functional groups in IR spectra also have positive and negative correlations with total flavonoid and yield extract responses.

show abstract

Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs

Cited by 2 publications

References 13 publications

Evaluation of Response Corellation Using Chemometrics Analysis for Pre-Optimization Quercetin – Self Emulsion Formulation

Evaluation of Response Corellation Using Chemometrics Analysis for Pre-Optimization Quercetin – Self Emulsion Formulation

FTIR-ATR based fingerprinting and chemometrics analysis of metabolites profile of Phyllanthus niruri L. affected by fertilization with NPK-chitosan nanopolymer and harvesting age

Contact Info

Product

Resources

About