Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E. coli and S. aureus

Akbarzadeh, Iman; Keramati, Maliheh; Azadi, Amir; Afzali, Elham; Shahbazi, Rasoul; Chiani, Mohsen; Norouzian, Dariush; Bakhshandeh, Haleh

doi:10.1016/j.chemphyslip.2020.105019

Cited by 45 publications

(20 citation statements)

References 54 publications

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“…Since no other studies have yet been published considering the effect of statins on the hallmarks of peri‐implantitis in humans, the results of this study warrants future clinical research on the effect of locally applied statins on peri‐implant tissue healing in humans as adjunct treatment to surgical peri‐implantitis therapy. Furthermore, studying carriers may be of interest due to current animal studies suggesting the importance of bioavailability of statins and its duration (Li et al, 2016; Ma et al, 2008), affecting the antibacterial properties (Akbarzadeh et al, 2021) and anti‐inflammatory effects of statins through lower T‐cell recruitment and higher vasoreactivity (Jain & Ridker, 2005). Additionally, types and dose limits of locally applied statins, leading to levels of eventual uptake in the body and nearby tissues, including effects on the peri‐implant microbiota (Belibasakis & Manoil, 2021), may need analysis and verification.…”

Section: Discussionmentioning

confidence: 99%

Peri‐implant marginal bone loss and systemic statin use: A retrospective cohort pilot study

Bahrami-Hessari

Jansson

2021

Clinical & Exp Dental Res

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Objectives: The aim was to analyze clinical parameters of peri-implantitis in human subjects exposed and non-exposed to use of systemic statins. Material and methods: This retrospective cohort pilot study compared patient records of 60 exposed individuals to 196 non-exposed individuals as of 2011 throughout 2017. Source of records were specialist and general dentistry clinics in Public Dental Service, Stockholm County, Sweden. Extent/severity of peri-implantitisand peri-implant bone loss were registered as well as intake of systemic statins. Background variables considered were bleeding on probing, bone-loss, age, gender, earlier periodontitis, prosthetic quality, and smoking. Stepwise linear and logistic regression analysis at the individual level was adopted in order to study the influence of statin use on the severity of peri-implantitis and the incidence of peri-implant bone loss.Results were considered statistically significant at p < 0.05.Results: Peri-implant bone loss was significantly correlated to use of statin after compensation for age and sex. Conclusions:The results render an actual effect of statins on peri-implant bone loss plausible. Further research is warranted.

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Section: Discussionmentioning

confidence: 99%

Peri‐implant marginal bone loss and systemic statin use: A retrospective cohort pilot study

Bahrami-Hessari

Jansson

2021

Clinical & Exp Dental Res

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“…In 2020, Akbarzadeh et al [ 66 ] prepared and optimized a niosomal formulation (a particular kind of drug delivery system employed for the topical delivery of lipophilic drugs) of simvastatin. Their findings suggested that niosomes notably reduced the drug-releasing rate and improved the antimicrobial effect against S. aureus and E. coli (MIC values amounting to 31.12 and 7.78, respectively).…”

Section: Statins As Antimicrobial Agentsmentioning

confidence: 99%

Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial Approach

et al. 2022

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The worldwide scenario of antibiotic resistance and the falling number of funds for the development of novel antibiotics have led research efforts toward the study of specific cost-effective strategies aimed at discovering drugs against microbial infections. Among the potential options, drug repositioning, which has already exhibited satisfactory results in other medical fields, came out as the most promising. It consists of finding new uses for previously approved medicines and, over the years, many “repurposed drugs” displayed some encouraging in vitro and in vivo results beyond their initial application. The principal theoretical justification for reusing already existing drugs is that they have known mechanisms of action and manageable side effects. Reuse of old drugs is now considered an interesting approach to overcome the drawbacks of conventional antibiotics. The purpose of this review is to offer the reader a panoramic view of the updated studies concerning the repositioning process of different classes of non-antibiotic drugs in the antimicrobial field. Several research works reported the ability of some non-steroidal anti-inflammatory drugs (NSAIDs), antidepressants, antipsychotics, and statins to counteract the growth of harmful microorganisms, demonstrating an interesting winning mode to fight infectious diseases caused by antimicrobial resistant bacteria.

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“…Suitable-sized niosomes are formed from appropriate ratios of span 80, drug, and cholesterol. Prepared niosomes have good stability and good antibacterial activity [124].…”

Section: Other Nanocarriersmentioning

confidence: 99%

Nanomaterials in the Management of Gram-Negative Bacterial Infections

et al. 2021

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The exploration of multiplexed bacterial virulence factors is a major problem in the early stages of Escherichia coli infection therapy. Traditional methods for detecting Escherichia coli (E. coli), such as serological experiments, immunoassays, polymerase chain reaction, and isothermal microcalorimetry have some drawbacks. As a result, detecting E. coli in a timely, cost-effective, and sensitive manner is critical for various areas of human safety and health. Intelligent devices based on nanotechnology are paving the way for fast and early detection of E. coli at the point of care. Due to their specific optical, magnetic, and electrical capabilities, nanostructures can play an important role in bacterial sensors. Another one of the applications involved use of nanomaterials in fighting microbial infections, including E. coli mediated infections. Various types of nanomaterials, either used directly as an antibacterial agent such as metallic nanoparticles (NPs) (silver, gold, zinc, etc.), or as a nanocarrier to deliver and target the antibiotic to the E. coli and its infected area. Among different types, polymeric NPs, lipidic nanocarriers, metallic nanocarriers, nanomicelles, nanoemulsion/ nanosuspension, dendrimers, graphene, etc. proved to be effective vehicles to deliver the drug in a controlled fashion at the targeted site with lower off-site drug leakage and side effects.

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Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E. coli and S. aureus

Cited by 45 publications

References 54 publications

Peri‐implant marginal bone loss and systemic statin use: A retrospective cohort pilot study

Peri‐implant marginal bone loss and systemic statin use: A retrospective cohort pilot study

Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial Approach

Nanomaterials in the Management of Gram-Negative Bacterial Infections

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