Optimization on Supercritical CO&lt;sub&gt;2&lt;/sub&gt; Extraction Process to Improve the Quality of Patchouli Oil by Response Surface Methodology Approach

Utomo, Edi Priyo; Marina, Marina; Warsito, Warsito; Agustian, Egi

doi:10.22146/ijc.26605

Cited by 6 publications

(3 citation statements)

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“…These reactive species are created in very high concentration and begin to migrate randomly about ) and dissolved oxygen are strong oxidizing agents that can oxidize silver atom into silver ion [10,25]. Since reduction and oxidation reactions occur randomly during the irradiation processing, the statistical optimization of the experimental conditions is critical in development of synthesis methods [26,27].…”

Section: Resultsmentioning

confidence: 99%

Response Surface Optimization of Gamma Irradiation Synthesis of Alginate-Stabilized Silver Nanoparticles Without Addition of a Hydroxyl Radical Scavenger

Perkasa¹,

Arozal²,

Kusmardi³

et al. 2022

Atom Indo.

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The use of isopropanol as a hydroxyl radical scavenger on the radiosynthesis of alginate-stabilized silver nanoparticles (AgNPs) can limit its application in nanomedicine. Meanwhile, optimum condition for gamma irradiation synthesis of alginate-stabilized AgNPs without addition of a hydroxyl radical scavenger has not been reported yet. In this study, the optimization of this process was carried out using response surface methodology (RSM) combined with Central Composite Design (CCD). The three processing conditions, i.e. radiation dose, precursor silver ion concentration, and alginate concentration were selected as decision variables to maximize two responses in terms of the conversion yield and AgNP concentration responses. The results indicated that the regression model of conversion yield and AgNP concentration fit linearly with the two-factor interaction and the linear model, respectively. The significant effect of the alginate factor on the conversion yield indicates the dual stabilizing-scavenging role of the alginate. The optimum conditions derived from CCD-RSM were obtained at a 20 kGy radiation dose, 7.78 mM precursor silver ion concentration, and 1.2 % (w/v) alginate concentration with the desirability of 0.731. The actual experimental results were 65.43% conversion yield and 480.91 ppm AgNP concentration, which were within the prediction interval at confidence of 95 %. The AgNPs under the optimum condition had a spherical shape, 97.4 % volume of size distribution at 6.50-28.21 nm, and zeta potential of -28.3 mV.

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Section: Resultsmentioning

confidence: 99%

Response Surface Optimization of Gamma Irradiation Synthesis of Alginate-Stabilized Silver Nanoparticles Without Addition of a Hydroxyl Radical Scavenger

Perkasa¹,

Arozal²,

Kusmardi³

et al. 2022

Atom Indo.

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“…Kusuma and Mahfud (2015) reported the extraction of patchouli oil using microwave for 51 minutes at 634 W and the optimum yield of patchouli oil was 2.80% [4]. Utomo et al (2017) used supercritical fluid extraction to extract patchouli oil at 135 atm for 252 minutes, yielding 25.34% [5]. To shorten the time and save solvent use, this study aims to optimize the extraction parameters of MAE like time and microwave power and then analyze the yield of patchouli alcohol result using RSM.…”

Section: Introductionmentioning

confidence: 99%

Patchouli Alcohol Optimization from Pogostemon cablin Benth. cv. Sidikalang Leaves Using Response Surface Methodology

Firmansyah,

Irwansyah,

Budipramana

et al. 2023

Advances in Biological Sciences Research

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The demand for essential oils in the industrial sector continues to increase, proportional to the number of people using them. Pogostemon cablin popularly known as nilam in Indonesia produces patchouli oil with patchouli alcohol as the major compound. Patchouli oil has been used for a long time as perfume ingredients, cosmetics, aromatherapy, insecticides, and pharmaceutical products. Currently, the production process of patchouli oil in Indonesia is not optimal. In order to increase the results of patchouli alcohol, microwave-assisted extraction (MAE) using ethanol 96% as solvent was performed for extraction and analyzed using gas chromatography (GC). Response surface methodology (RSM) statistic was used to calculate the concentration of patchouli alcohol with parameters microwave power (180-600 W) and extraction time (25-60 seconds). The experiment results showed the optimum conditions for extraction were 60 seconds at 600 W with patchouli alcohol (0.23%) and these result similar to patchouli alcohol (0.25%) predicted by RSM for 60 s at 600 W.

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“…In order to improve the quality of patchouli oil to an internationally acceptable standard, the quality of patchouli oil needs to be enhanced by selecting the right method. Utomo et al [10] reported that the distillation or redistillation method in refining can reduce some important impurities, therefore, a comparative research is conducted using supercritical CO2 fluid extraction. Donelian et al [11] evaluated three different membranes (polyamide, polypiperazine amide and polyamide film) in the separation of the oil's components.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Calcium Oxide/Zeolite Nanocomposite and its Application to Improve the Quality of Patchouli Oil

Wijaya

Utami

Syoufian

et al. 2020

KEM

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The synthesis of CaO/zeolite nanocomposite as a highly active and effective adsorbent for patchouli oil purification has been developed. This research aims to improve the quality of patchouli oil by synthesizing CaO/zeolite nanocomposites using a solid-state mixing method. The used mass ratios of zeolite:CaO were 0:100, 20:80, 40:60, 60:40, 80:20 and 100:0 (w/w), then nanocomposites with various zeolite-to-CaO ratios were then calcined at various temperature of 300°C, 400°C and 500°C. The zeolite, CaO and nanocomposites were characterized by using the Fourier-transform infrared (FTIR), X-ray fluorescence spectrometer (XRF) and surface area analyzer (SAA). The nanocomposites were then applied to patchouli oil and the assessment results of physical and chemical properties of patchouli oil were determined according to Indonesian National Standard (SNI) 06-2385-2006. After patchouli oil purification using ZECA nanocomposite, the acid number decreased from 5.42 to 0.39 mg KOH/g oil, the patchouli alcohol (PA) content increased from 33.08 to 34.27% and the Fe level decreased from 1.39 to 0.31 ppm.

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Optimization on Supercritical CO<sub>2</sub> Extraction Process to Improve the Quality of Patchouli Oil by Response Surface Methodology Approach

Cited by 6 publications

References 0 publications

Response Surface Optimization of Gamma Irradiation Synthesis of Alginate-Stabilized Silver Nanoparticles Without Addition of a Hydroxyl Radical Scavenger

Response Surface Optimization of Gamma Irradiation Synthesis of Alginate-Stabilized Silver Nanoparticles Without Addition of a Hydroxyl Radical Scavenger

Patchouli Alcohol Optimization from Pogostemon cablin Benth. cv. Sidikalang Leaves Using Response Surface Methodology

Preparation of Calcium Oxide/Zeolite Nanocomposite and its Application to Improve the Quality of Patchouli Oil

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