Optimization of water extract of Cinnamomum burmannii bark to ascertain its in vitro antidiabetic and antioxidant activities

Ervina, Martha; Lie, Han Sanjaya; Diva, Jesslyn; Caroline, Caroline; Tewfik, Sundus; Tewfik, Ihab

doi:10.1016/j.bcab.2019.101152

Cited by 19 publications

(23 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The essential oil of this herb has been shown to have antioxidant activity. Other studies have reported antioxidant activities of water, methanol, and ethanolic cinnamon extracts [ 45 , 46 , 136 , 137 , 138 ]. This plant shows high anti-influenza virus activity [ 139 ].…”

Section: Antimicrobial Agentmentioning

confidence: 99%

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

et al. 2020

View full text Add to dashboard Cite

Recently, increasing public concern about hygiene has been driving many studies to investigate antimicrobial and antiviral agents. However, the use of any antimicrobial agents must be limited due to their possible toxic or harmful effects. In recent years, due to previous antibiotics’ lesser side effects, the use of herbal materials instead of synthetic or chemical drugs is increasing. Herbal materials are found in medicines. Herbs can be used in the form of plant extracts or as their active components. Furthermore, most of the world’s populations used herbal materials due to their strong antimicrobial properties and primary healthcare benefits. For example, herbs are an excellent material to replace nanosilver as an antibiotic and antiviral agent. The use of nanosilver involves an ROS-mediated mechanism that might lead to oxidative stress-related cancer, cytotoxicity, and heart diseases. Oxidative stress further leads to increased ROS production and also delays the cellular processes involved in wound healing. Therefore, existing antibiotic drugs can be replaced with biomaterials such as herbal medicine with high antimicrobial, antiviral, and antioxidant activity. This review paper highlights the antibacterial, antiviral, and radical scavenger (antioxidant) properties of herbal materials. Antimicrobial activity, radical scavenger ability, the potential for antimicrobial, antiviral, and anticancer agents, and efficacy in eliminating bacteria and viruses and scavenging free radicals in herbal materials are discussed in this review. The presented herbal antimicrobial agents in this review include clove, portulaca, tribulus, eryngium, cinnamon, turmeric, ginger, thyme, pennyroyal, mint, fennel, chamomile, burdock, eucalyptus, primrose, lemon balm, mallow, and garlic, which are all summarized.

show abstract

Section: Antimicrobial Agentmentioning

confidence: 99%

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In another study [ 34 ], purified PACs from M. philippinensis strongly inhibited the activity of α-glucosidase. The strong anti-glucosidase activity of C. burmannii water extract was attributed to polymers of PACs and other flavan-3-ols [ 14 ]. PACs were the main inhibitors of C. osmophloeum extract against carbohydrate-hydrolyzing enzymes [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…Cinnamon ( Cinnamomum spp.) is one of the most popular spices used worldwide [ 14 , 15 ]. In vitro and in vivo data show that cinnamon improves post-prandial hyperglycaemia, triglycerides, LDL cholesterol, total cholesterol, and prevents protein glycation [ 10 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Assessing the In Vitro Inhibitory Effects on Key Enzymes Linked to Type-2 Diabetes and Obesity and Protein Glycation by Phenolic Compounds of Lauraceae Plant Species Endemic to the Laurisilva Forest

Spínola

Castilho

2021

Molecules

View full text Add to dashboard Cite

Methanolic leaf extracts of four Lauraceae species endemic to Laurisilva forest (Apollonias barbujana, Laurus novocanariensis, Ocotea foetens and Persea indica) were investigated for the first time for their potential to inhibit key enzymes linked to type-2 diabetes (α-amylase, α-glucosidase, aldose reductase) and obesity (pancreatic lipase), and protein glycation. Lauraceae extracts revealed significant inhibitory activities in all assays, altough with different ability between species. In general, P. indica showed the most promissing results. In the protein glycation assay, all analysed extracts displayed a stronger effect than a reference compound: aminoguanidine (AMG). The in vitro anti-diabetic, anti-obesity and anti-glycation activities of analysed extracts showed correlation with their flavonols and flavan-3-ols (in particular, proanthocyanins) contents. These Lauraceae species have the capacity to assist in adjuvant therapy of type-2 diabetes and associated complications, through modulation of the activity of key metabolic enzymes and prevention of advanced glycation end-products (AGEs) formation.

show abstract

“…Kayu manis merupakan rempah pemberi cita rasa (flavor) di industri farmasi, kosmetik dan pangan serta sebagai obat tradisional maupun pengobatan modern (Sangal, 2011;Dhubiab, B. E., 2012) Kayu manis telah diketahui mengetahui senyawa bioaktif yang bermanfaat bagi kesehatan manusia. Kayu manis mengandung senyawa bioaktif seperti polifenol (termasuk flavonoid, tanin) dan senyawa minyak atsiri fenolik serta kumarin, polimer proantosianin tipe A dan heterodimeer terprotonasi gugus flavon-3ol, katekin, epikatekin, prosianidin B2, kuersetin, 3,4-dihidroksibenzaldehid, dan asam sinamat sebagai senyawa antioksidan utama (Ervina et al, 2016;Ervina et al, 2019;Kim et al, 2016;Muhammad et al, 2020;Sikand et al, 2015). Dalam studi tentang manfaat kayu manis untuk mencegah diabetes dan penyakit Alzheimer, Peterson et al, (2009) menemukan bahwa ekstrak air kulit kayu manis mengandung polifenol.…”

Section: Pendahuluanunclassified

Aktivitas Antioksidan Ekstrak Etanol Kayu Manis (Cinnamomum burmani) Secara In Vitro / Antioxidant Activities Of Cinnamon (Cinnamomum burmani) In Vitro

Antasionasti¹,

Jayanto²

2021

jfu

View full text Add to dashboard Cite

ABSTRACT Cinnamon (Cinnamomum burmani) is a spice that can be used as an additive in food and cakes as well as a pharmaceutical ingredient in the pharmaceutical industry. Therefore, the exploration of cinnamon as a natural antioxidant is highly needed. The study aims is to investigate the antioxidant activity of cinnamon using the DPPH, ABTS radical assay and ferric reducing activity power (FRAP) as well as total phenolic and total flavonoids. Cinnamon was extracted using the maceration technique by ethanol 96% as a solvent and tested for antioxidant activity. The antioxidant activity of DPPH, ABTS, and FRAP that showed by the ethanol extract of cinnamon were 1.939 ± 0.055 ?g/mL; 2,235 ± 0.014 ?g/mL; and 1415.705 ± 38.609 mg of ascorbic acid/gram extract, respectively. The antiradical activity of the ethanol extract of cinnamon was lower than vitamin C, namely 0.554 ± 0.003 ?g/mL (DPPH) and 0.813 ± 0.028 ?g/mL (ABTS). The antioxidant activity provided by the ethanol extract of cinnamon was influenced by the total phenolic content and total flavonoids, respectively 75.685 ± 1.408 % EAG and 60,546 ± 0,670% EK. Cinnamon has very strong antioxidant activity, contains high amounts of total phenolic and total flavonoids so that it has the potential to be a food additive (antioxidant) in the food and pharmaceutical industries.

show abstract

Optimization of water extract of Cinnamomum burmannii bark to ascertain its in vitro antidiabetic and antioxidant activities

Cited by 19 publications

References 24 publications

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

Assessing the In Vitro Inhibitory Effects on Key Enzymes Linked to Type-2 Diabetes and Obesity and Protein Glycation by Phenolic Compounds of Lauraceae Plant Species Endemic to the Laurisilva Forest

Aktivitas Antioksidan Ekstrak Etanol Kayu Manis (Cinnamomum burmani) Secara In Vitro / Antioxidant Activities Of Cinnamon (Cinnamomum burmani) In Vitro

Contact Info

Product

Resources

About