Optimization of the production of [61Cu]Diacetyl-bis(N4-methylthiosemicarbazone) for PET studies

Jalilian, Amir Reza; Sabet, Mahsheed; Rowshanfarzad, Pejman; Kamali-Dehghan, Mohsen; Akhlaghi, Mehdi; Mirzaii, M.

doi:10.1007/s10967-006-0244-0

Cited by 8 publications

(4 citation statements)

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“…Serum stability studies using radiometal-labeled chelator complexes or their bioconjugates are routinely used in inertness assays. These are readily monitored by radio-TLC, HPLC and LC-MS techniques 47-49 . In vitro uptake studies using specific cell lines have also been carried out in many assays.…”

Section: 0 the Coordination Chemistry Of Cu Ga Y In And Zrmentioning

confidence: 99%

Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease

et al. 2010

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Section: 0 the Coordination Chemistry Of Cu Ga Y In And Zrmentioning

confidence: 99%

Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease

et al. 2010

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“…The synthesis; structure, antitumor property, toxicity and glutathione (GSH) depletion property in vivo of the NHAG copper complex has also been reported previously [12]. Regarding these properties development of a possible copper tracer using this complex seemed interesting to us based on our recent experiences on radiocopper production via nat Zn(p,x) 61 Cu [13] and developing important Cu-radiopharmaceuticals in our research group [14,15].…”

Section: Introductionmentioning

confidence: 57%

Synthesis and Preclinical Studies of [61Cu]-N-(2-hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical

Jalilian¹,

Sadeghi

Zandi

et al. 2008

Sci. Pharm.

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Zn(p,x) 61 Cu (180μA proton irradiation, 22MeV, 3.2h) and purified by a ion chromatography method. [ 61 Cu]NHAG radiochemical purity was >98% and >99.9% by RTLC and HPLC methods respectively after purification by SPE. [ 61 Cu]NHAG was administered into normal and tumor bearing mice followed by biodistribution studies up to 180 minutes. The best tumor accumulation was observed by animal sacrification after 120 min (tumor/muscle and tumor/blood ratios were 25.6 and 3.4 respectively). [ 61 Cu]NHAG is a potential PET radiotracer for tumor imaging.

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“…Based on the interesting properties of copper-61 and the possibility of its production via nat Zn(p,x) 61 Cu, we have already reported a production method (10), and in continuation of this work we hereby report the preclinical studies of [ 61 Cu]ATSM as an imaging agent in normal rodents and animals with hypoxic tumors.…”

mentioning

confidence: 87%

Preclinical studies of [61Cu]ATSM as a PET radiopharmaceutical for fibrosarcoma imaging

Jalilian¹,

Rostampour²,

Rowshanfarzad³

et al. 2009

Acta Pharmaceutica

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Preclinical studies of [61Cu]ATSM as a PET radiopharmaceutical for fibrosarcoma imaging [61Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([61Cu] ATSM) was prepared using in house-made diacetyl-bis(N4-methylthiosemicarbazone) (ATSM) ligand and [61Cu]CuCl2 produced via the natZn(p, x)61Cu (180 μA proton irradiation, 22 MeV, 3.2 h) and purified by a ion chromatography method. [61Cu]ATSM radiochemical purity was >98 %, as shown by HPLC and RTLC methods. [61Cu]ATSM was administered into normal and tumor bearing rodents for up to 210 minutes, followed by biodistribution and co-incidence imaging studies. Significant tumor/non-tumor accumulation was observed either by animal sacrification or imaging. [61Cu]ATSM is a positron emission tomography (PET) radiotracer for tumor hypoxia imaging.

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Optimization of the production of [61Cu]Diacetyl-bis(N4-methylthiosemicarbazone) for PET studies

Cited by 8 publications

References 0 publications

Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease

Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease

Synthesis and Preclinical Studies of [61Cu]-N-(2-hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical

Preclinical studies of [61Cu]ATSM as a PET radiopharmaceutical for fibrosarcoma imaging

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