Synthesis and Preclinical Studies of [61Cu]-N-(2-hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical

Jalilian, Amir Reza; Sadeghi, Hamid Reza; Zandi, Hassan Gharayagh; Rowshanfarzad, Pejman; Shafaii, Kamaledin; Kamali-Dehghan, Mohsen; Garousi, Javad; Majdabadi, Abbas; Tavakoli, Mahdi

doi:10.3797/scipharm.0808-13

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…The best tumour accumulation result was at 2 h (tumour/blood and tumour/muscle ratios were 3.43 and 25.64, respectively). Based on the results obtained, Cu‐02 has potential application as a PET radiotracer for tumour imaging [58] …”

Section: Complexes With Tridentate Schiff Bases O N O With Metals Of ...mentioning

confidence: 94%

Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

et al. 2022

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Although it is known that the first case of cancer was recorded in ancient Egypt around 1600 BC, it was not until 1917 during the First World War and the development of mustard gas that chemotherapy against cancer became relevant; however, its properties were not recognised until 1946 to later be used in patients. In this sense, the use of metallopharmaceuticals in cancer therapy was extensively explored until the 1960s with the discovery of cisplatin and its anticancer activity. From that date to the present, the search for more effective, more selective metallodrugs with fewer side effects has been an area of continuous exploration. Efforts have led to considering a wide variety of metals from the periodic table, mainly from the d-block, as well as a wide variety of organic ligands, preferably with proven biological activity. In this sense, various research groups have found an ideal binder in Schiff bases, since their raw materials are easily accessible, their synthesis conditions are friendly and their denticity can be manipulated. Therefore, in this review, we have explored the anticancer and antitumor activity reported in the literature for coordination complexes of d-block metals coordinated with tridentate Schiff bases (O N O and O N N) derived from salicylaldehyde. For this work, we have used the main scientific databases CCDC® and SciFinder®.

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Section: Complexes With Tridentate Schiff Bases O N O With Metals Of ...mentioning

confidence: 94%

Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

et al. 2022

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Production and Clinical Applications of Radiopharmaceuticals and Medical Radioisotopes in Iran

Jalilian

Beiki

Hassanzadeh-Rad

et al. 2016

Seminars in Nuclear Medicine

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Synthesis and Preclinical Studies of [61Cu]-N-(2-hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical

Cited by 2 publications

References 19 publications

Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

Production and Clinical Applications of Radiopharmaceuticals and Medical Radioisotopes in Iran

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