The active flow control technique of vortex-generator jet (VGJ) was used to control the turbulent separation of a highly loaded compressor cascade at a high incidence. VGJ schemes on suction surface with different jet locations, skewed angles, pitch angles were numerically performed and the control mechanism of VGJ parameters on the flow field of the cascade was revealed. For avoiding the effect of endwall boundary layer, both endwall surfaces of the cascade were set to translational periodicity boundary (TPB). Results show that VGJ significantly eliminates the turbulent separation and improves the performance of cascade. The overall loss coefficient of cascade is reduced by 52.3% at most. The optimal VGJ location in this study is not separation location but 7% axial chord downstream of it, which is probably due to the ultra-high loading of the cascade. The spanwise location and intensity of jet vortices are mainly affected by skewed angle, and will increase with the skewed angle. The VGJ case with a higher pitch angle features better control effect on suction surface but increases the pitchwise scale of the low-velocity region. In addition, as pitch angle increases, the mixing loss between mainstream and jet flow increases, which brings a negative effect on cascade performance. In order to enhance the momentum transporting between mainstream flow and separation flow, counter vortex-generator jet (CVGJ) schemes were designed and studied. Though CVGJ strengthens the jet vortices near the trailing edge and achieves minimum loss near TPB sections at 150% axial chord section, the interaction of jet vortices with opposite rotating direction brings extra loss, which leads to the control effect of CVGJ is weaker than that of VGJ.