Optimization of supercritical CO2 extraction of different anatomical parts of lovage (Levisticum officinale Koch.) using response surface methodology and evaluation of extracts composition

Kemzūraitė, Aurelija; Venskutonis, Petras Rimantas; Baranauskienė, Renata; Navikienė, Diana

doi:10.1016/j.supflu.2014.01.007

Cited by 22 publications

(9 citation statements)

References 36 publications

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“…Pressure, temperature, and extraction time had significant effects on extract yields of lovage roots ( p < 0.05), while extraction time for leaves was insignificant in the model. The quadratic of pressure and interactions of pressure and temperature were significant factors both for leaves and roots, whereas interactions of temperature and time, pressure and time, and quadratic of time and temperature were insignificant factors and the experimental values were in agreement with those predicted by computation 23. The effect of particle size was not remarkable for SFE‐CO 2 extraction yields (Fig.…”

Section: Resultssupporting

confidence: 74%

“…Response surface methodology (RSM) involving central composite design (CCD), response surface modeling through regression analysis, and process optimization via response surface models 21 was applied to predict the optimum SFE‐CO 2 parameters 22, 23. The three‐level factorial layout for CCD consisted of twenty SFE‐CO 2 process runs, including eight factorial, six axial, and six center points.…”

Section: Methodsmentioning

confidence: 99%

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Processing of Lovage into High‐Value Components Using Supercritical CO₂ and Pressurized Liquid Extraction

2014

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Lovage roots, leaves, and stems were extracted by supercritical carbon dioxide (SFE-CO 2 ), while the residues of SFE-CO 2 were further extracted by pressurized liquid extraction with acetone and methanol. Optimization of SFE-CO 2 parameters resulted in enhanced extract yields from all lovage parts. The antioxidant potential of solid material and extracts was assessed by Trolox-equivalent antioxidant capacity (TEAC) in two different assays and by the total phenolic content (TPC). TEAC and TPC values of SFE-CO 2 residues were distinctly lower than those of the initial lovage material which indicates that lovage antioxidants are distributed both in lipophilic and fat-insoluble fractions.

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Section: Resultssupporting

confidence: 74%

Section: Methodsmentioning

confidence: 99%

Processing of Lovage into High‐Value Components Using Supercritical CO₂ and Pressurized Liquid Extraction

2014

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“…A number of pharmacological studies has proved its effectiveness as an antioxidant [ 16 ], analgesic, anti-inflammatory [ 17 ], antidiabetic [ 18 ], cardioprotective [ 19 ], photoprotective [ 20 ] and anticancer [ 21 ] agent. Z -LG is found in some medicinal plants including Cnidii Rhizoma, Angelica sinensis and Levisticum officinale and is also widely recognized as an anti-inflammatory agent and anti-oxidant [ 22 , 23 , 24 ]. Recently, the pharmacological activity of Z -LG has been investigated and it has been shown to exhibit neuroprotective [ 25 ], anti-Alzheimer [ 22 ], anticancer [ 26 ] and anti-inflammatory [ 27 ] effects.…”

Section: Introductionmentioning

confidence: 99%

Cytoprotective Effects of Mangiferin and Z-Ligustilide in PAH-Exposed Human Airway Epithelium in Vitro

et al. 2019

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According to World Health Organisation (WHO) air pollution increases the risk of cardiovascular disorders, respiratory diseases, including COPD, lung cancer and acute respiratory infections, neuro-degenerative and other diseases. It is also known that various phytochemicals may mitigate such risks. This study tested if phytochemicals mangiferin (MNG) and Z-ligustilide (Z-LG) may protect PAH-exposed human lung bronchial epithelial cells (BEAS-2B). Organic PAH extract was obtained from the urban fine PM with high benzo(a)pyrene content collected in Eastern European mid-sized city during winter heating season. Cell proliferation traits and levels of intracellular oxidative stress were examined. Effect of MNG (0.5 µg/mL) alone or in combination with PAH on bronchial epithelium wound healing was evaluated. Both phytochemicals were also evaluated for their antioxidant properties in acellular system. Treatment with MNG produced strong cytoprotective effect on PAH-exposed cells (p < 0.01) while Z-LG (0.5 µg/mL) exhibited strong negative effect on cell proliferation in untreated and PAH-exposed cells (p < 0.001). MNG, being many times stronger antioxidant than Z-LG in chemical in vitro assays (p < 0.0001), was also able to decrease PAH-induced oxidative stress in the cell cultures (p < 0.05). Consequently MNG ameliorates oxidative stress, speeds up wound healing process and restores proliferation rate in PAH-exposed bronchial epithelium. Such protective effects of MNG in air pollution affected airway epithelium stimulate further research on this promising phytochemical.

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“…The following conditions were set: extraction pressure and temperature were 45 MPa and 60 • C, respectively. Very similar parameters have been found to ensure a high extraction yield, as per our previous investigations [20,21]. A static extraction time of 30 min was kept followed by 360 min of total dynamic extraction.…”

Section: Supercritical Carbon Dioxide Extraction (Sfe-co 2 )mentioning

confidence: 66%

High-Pressure Extraction of Antioxidant-Rich Fractions from Shrubby Cinquefoil (Dasiphora fruticosa L. Rydb.) Leaves: Process Optimization and Extract Characterization

et al. 2020

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Dasiphora fruticosa (basionym Potentilla fruticosa) is a shrub, known in traditional medicine for centuries. Due to the wide range of pharmacological effects, interest and applications of D. fruticosa extracts are continually increasing; however, reports on optimization of extraction conditions are scarce. Herein, a multi-step high-pressure extraction process with increasing polarity solvents was developed to isolate valuable fractions from D. fruticosa leaves. Supercritical CO2 extraction recovered 2.46 g/100 g of lipophilic fraction, rich in polyunsaturated fatty acids. Further, pressurized liquid extractions (PLE) with acetone, ethanol, and water were applied to obtain antioxidant-rich higher polarity extracts. Under optimized PLE conditions, the cumulative polar fraction yield was 29.98 g/100 g. Ethanol fraction showed the highest yield (15.3 g/100 g), TPC values (148.4 mg GAE/g), ABTS•+, and DPPH• scavenging capacity (161.1 and 151.8 mg TE/g, respectively). PLE was more efficient than conventional solid–liquid extraction in terms of extraction time, extract yields, and in vitro antioxidant capacity. Phytochemical characterization of PLE extracts by UPLC-Q-TOF-MS revealed the presence of hyperoside, ellagic acid, among other health beneficial phenolic substances. Τhis study highlights the potential of high-pressure extraction techniques to isolate antioxidant-rich fractions from D. fruticosa leaves with multipurpose applications, including the prevention and treatment of chronic diseases.

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Optimization of supercritical CO2 extraction of different anatomical parts of lovage (Levisticum officinale Koch.) using response surface methodology and evaluation of extracts composition

Cited by 22 publications

References 36 publications

Processing of Lovage into High‐Value Components Using Supercritical CO₂ and Pressurized Liquid Extraction

Processing of Lovage into High‐Value Components Using Supercritical CO₂ and Pressurized Liquid Extraction

Cytoprotective Effects of Mangiferin and Z-Ligustilide in PAH-Exposed Human Airway Epithelium in Vitro

High-Pressure Extraction of Antioxidant-Rich Fractions from Shrubby Cinquefoil (Dasiphora fruticosa L. Rydb.) Leaves: Process Optimization and Extract Characterization

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Optimization of supercritical CO2 extraction of different anatomical parts of lovage (Levisticum officinale Koch.) using response surface methodology and evaluation of extracts composition

Cited by 22 publications

References 36 publications

Processing of Lovage into High‐Value Components Using Supercritical CO2 and Pressurized Liquid Extraction

Processing of Lovage into High‐Value Components Using Supercritical CO2 and Pressurized Liquid Extraction

Cytoprotective Effects of Mangiferin and Z-Ligustilide in PAH-Exposed Human Airway Epithelium in Vitro

High-Pressure Extraction of Antioxidant-Rich Fractions from Shrubby Cinquefoil (Dasiphora fruticosa L. Rydb.) Leaves: Process Optimization and Extract Characterization

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Processing of Lovage into High‐Value Components Using Supercritical CO₂ and Pressurized Liquid Extraction

Processing of Lovage into High‐Value Components Using Supercritical CO₂ and Pressurized Liquid Extraction