Optimization of prostate carcinoma staging: Comparison of imaging and clinical methods

Böni, R.; Boner, J A; Debatin, J. F.; Trinkler, Felix; Knönagel, H; Hochstetter, A. R. von; Helfenstein, Ulrich; Krestin, Gabriël P.

doi:10.1016/s0009-9260(05)83287-8

Cited by 69 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is considerable variation in the reported sensitivity of MRI for staging patients and considerable interobserver variation in the interpretation of MRI [2–9]. The sensitivity of eMRI strongly depends on the experience of the radiologist.…”

Section: Discussionmentioning

confidence: 99%

“…Variable results have been reported to date for the utility of endorectal coil MRI (eMRI) in staging prostate cancer, ranging from those against routine use [2–4] to enthusiasm for the method [5,6] when this technology was introduced. From the recent results showing the low specificity of MRI in particular, most urologists have probably discounted conventional or eMRI as a routine method for the preoperative staging of prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Limited value of endorectal magnetic resonance imaging and transrectal ultrasonography in the staging of clinically localized prostate cancer

et al. 2001

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Limited value of endorectal magnetic resonance imaging and transrectal ultrasonography in the staging of clinically localized prostate cancer

et al. 2001

View full text Add to dashboard Cite

show abstract

“…THE USE OF MAGNETIC resonance imaging (MRI) for prostate cancer (PCa) staging has been extensively studied (1–3), and is showing promise for tumor localization. Accurate characterization of tumor location and extent is vital to ensure optimal delivery of emerging focal therapies (4, 5), and may also impact patient management during active surveillance (6).…”

mentioning

confidence: 99%

Prostate cancer detection with multi‐parametric MRI: Logistic regression analysis of quantitative T2, diffusion‐weighted imaging, and dynamic contrast‐enhanced MRI

Langer

Kwast

Evans

et al. 2009

Magnetic Resonance Imaging

311

226

View full text Add to dashboard Cite

Purpose:To develop a multi-parametric model suitable for prospectively identifying prostate cancer in peripheral zone (PZ) using magnetic resonance imaging (MRI). Materials and Methods:Twenty-five radical prostatectomy patients (median age, 63 years; range, 44 -72 years) had T2-weighted, diffusion-weighted imaging (DWI), T2-mapping, and dynamic contrast-enhanced (DCE) MRI at 1.5 Tesla (T) with endorectal coil to yield parameters apparent diffusion coefficient (ADC), T2, volume transfer constant (K trans ) and extravascular extracellular volume fraction (v e ). Whole-mount histology was generated from surgical specimens and PZ tumors delineated. Thirty-eight tumor outlines, one per tumor, and pathologically normal PZ regions were transferred to MR images. Receiver operating characteristic (ROC) curves were generated using all identified normal and tumor voxels.Step-wise logistic-regression modeling was performed, testing changes in deviance for significance. Areas under the ROC curves (A z ) were used to evaluate and compare performance. .719], which was significantly higher than A z,T2 , A z,Ktrans , and A z,ve (P Ͻ 0.002). A z,LR-3p tended to be greater than A z,ADC , however, this result was not statistically significant (P ϭ 0.090). Conclusion:Using logistic regression, an objective model capable of mapping PZ tumor with reasonable performance can be constructed.

show abstract

“…Digital rectal examination alone will understage up to 81% of patients (4–6). The use of complex mathematical formulas (7, 8) integrating variables such as descriptive TRUS findings, serum PSA levels, and Gleason scores resulted in 94% positive predicting value and 60% negative predicting value (9, 10). All predictions using a statistically based algorithm lack the ability to conclusively diagnose local invasiveness with certainty (11).…”

Section: Discussionmentioning

confidence: 99%

Preoperative Detection of Locally Advanced Prostate Cancer by Using Transrectal Ultrasound‐Guided Staging Prostate Biopsy

et al. 2000

View full text Add to dashboard Cite

Treatment for cure is reserved for patients with organ‐confined prostate cancer. The clinical staging of prostate cancer lacks accuracy regarding local extension. The results of a transrectal ultrasound‐guided staging biopsy (TGSB), performed in addition to routine sextant biopsies (RSBs) of the prostate, is defined as being positive when tumor cells are shown to invade extraprostatic loci and, thus, would certainly differentiate between organ‐confined and locally advanced disease. Seventy‐seven RSB + TGSB procedures were compared to 223 routine sextant prostate TRGBs. Prostate cancer (CaP) was detected in 24 patients (31%) and 60 patients (27%), respectively. In four RSB + TGSB procedures, local extension of CaP was depicted, and as a result radical prostatectomy was withheld. In six of seven patients undergoing radical prostatectomy (86%), the specimen analysis result was in agreement with the results of the preoperative TGSB. There were no extra complications associated with the performance of staging biopsies. We conclude that TGSB is safe and efficacious and that it should be performed in candidates for radical prostatectomy.

show abstract

Optimization of prostate carcinoma staging: Comparison of imaging and clinical methods

Cited by 69 publications

References 20 publications

Limited value of endorectal magnetic resonance imaging and transrectal ultrasonography in the staging of clinically localized prostate cancer

Limited value of endorectal magnetic resonance imaging and transrectal ultrasonography in the staging of clinically localized prostate cancer

Prostate cancer detection with multi‐parametric MRI: Logistic regression analysis of quantitative T2, diffusion‐weighted imaging, and dynamic contrast‐enhanced MRI

Preoperative Detection of Locally Advanced Prostate Cancer by Using Transrectal Ultrasound‐Guided Staging Prostate Biopsy

Contact Info

Product

Resources

About