Optimization of Preoperative Preparation in Complex Treatment of Generalized Periodontitis

Antonenko, M; Zelinska, Natalia Antonivna; Значкова, О.А.; Melnichuk, T.A.; Syroyishko, M.V.

doi:10.26693/jmbs01.02.008

Ukr. ž. med. bìol. sportu

2016

DOI: 10.26693/jmbs01.02.008

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Optimization of Preoperative Preparation in Complex Treatment of Generalized Periodontitis

M Antonenko¹,

Natalia Antonivna Zelinska²,

О.А. Значкова³

et al.

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2024

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Cited by 6 publications

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“…However, there is always the risk of postoperative complications [13,14]. This called for further research in this direction with the aim of finding ways to optimize the interventions undertaken by increasing efficiency of pathogenetically targeted drug therapy.…”

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confidence: 99%

Morphometric indicators of wound bone tissue condition after surgical treatment of spontaneous periodontitis accompanied by different functional state of organism reactivity

Yarov¹

2023

ZMJ

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In periodontal surgery, advanced technologies such as the use of platelet-enriched plasma, the technique of directed tissue regeneration, applying various osteoplastic materials are widely spread. Despite the undoubted achievements, there is a risk of postoperative complications. The aim of the work was to study the intensity and duration of the wound healing phases after surgical treatment of spontaneous periodontitis accompanied by normo-, hyper- or hyporeactivity of the body by bone morphometry. Materials and methods. Wistar rats were selected for the study ‒ 90 nonlinear white adult male rats weighing 270 ± 58 grams, aged 11–12 months with spontaneous periodontitis. The animals were divided into three equal groups depending on the condition of their organism reactivity. All the animals underwent surgery on the periodontium: one half of the animals in each of the three groups underwent flap operations, the other – flap operations with osteoplasty (Kolapan-L, Hypro-sorb F). The specific weight of microhemocirculatory bed, connective tissue and bone granulation tissue, bone trabeculae, bone marrow cavities, polymorphonuclear leukocytes, lymphocytes, macrophages, plasma cells was studied by a morphometric method. Results. Morphometric study of bone wound preparations from animals with spontaneous periodontitis accompanied by normoreactivity of the body has allowed to identify the following phases of healing during the wound process: degenerative-inflammatory changes (the 10th day), an increase in reparative processes (the 20th day) and active regeneration (the 30th day). In cases of hyper- and hyporeactivity, the intensity and duration of the wound healing phases differed. In case of hyperreaction, the granulocyte-macrophage reaction was more expressed and lasted longer until the 20th day, therefore later, only on the 30th day, the signs of regeneration could be observed. In case of hyporeaction, the granulocyte reaction appeared later (only on the 20th day) and lasted longer, signs of active regeneration were noticed later, on the 30th day. The identified patterns occurred regardless of the absence or presence of osteoplastic material in a wound. Conclusions. In case of normoreactivity, the intensity and timing of the wound process phases were optimal. In case of impaired (hyper- and hypo-) reactions, altered intensity of the cellular phase (increased or decreased) and terms (accelerated or slowed down) resulted in delayed bone wound healing, that is, a complicated course was observed. It justifies the feasibility and necessity of developing methods of targeted drug correction for transforming the wound process phases with impaired body reactivity into those that are typical of normoreaction.

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confidence: 99%

Morphometric indicators of wound bone tissue condition after surgical treatment of spontaneous periodontitis accompanied by different functional state of organism reactivity

Yarov¹

2023

ZMJ

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Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?

Shcherba

Krynytska

Корда

2021

Endocrine Regulations

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Objective. The aim of the present study was to investigate the presence of inflammatory mediators in rats with only periodontitis and periodontitis in a setting of hyper- and hypo-thyroidism and to analyze the correlative linkages between inflammatory mediators and thyroid hormones. Methods. White male 12–14 weeks old inbred rats (n=48) weighing 180–200 g were employed in the experiment. They were randomly divided into the following groups: Group I – control group, Group II – group with a model of periodontitis, Group III – group with a periodontitis in a setting of hyperthyroidism, and Group IV – group with periodontitis in a setting of hypothyroidism. The presence of tumor-necrosis factor-α (TNF-α) and interleukins IL-1β and IL-10 in the periodontal homogenate supernatant was studied by a solid-phase enzyme-linked immunosorbent assay. Results. It was shown that experimental lipopolysaccharide (LPS)-induced periodontitis is accompanied by hyperproduction of pro-inflammatory cytokines (TNF-α, IL-1β) and reduction of anti-inflammatory cytokines (IL-10), whereas TNF-α underwent to maximum changes. Thyroid dysfunction exacerbates cytokine imbalance and severity of inflammation in experimental LPS-induced periodontitis, especially pronounced at hyperthyroidism, as evidenced by the predominance of TNF-α and IL-1β levels in the periodontal homogenate supernatant by 38.5% (р<0.01) and 75.6% (p<0.001), respectively, hyperthyroid over the euthyroid, and by 20.1% (p<0.05) and 24.1% (p<0.05), respectively, over the hypothyroid rats. Conclusions. Thyroid dysfunction, especially hyperthyroidism, may play an important role in the pro-inflammatory response in periodontitis. Hyperproduction of inflammatory mediators in thyroid dysfunction can induce a noticeable damage in the whole apparatus of the periodontium, thereby causing progression of periodontitis.

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Index Assessment of Periodontal Tissue and Oral Hygiene of Patients at the Preoperative Stage of Treatment of Generalized Periodontitis Ii-Iii Degree

Futrak

2024

Ukr. Dent. Alm.

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A significant concern in modern dentistry is the increasing prevalence of periodontitis among the Ukrainian population. At present, there is a high frequency of diagnosis for initial-І degree and II-degree periodontitis in our country. However, a comprehensive comparative chronological analysis of index evaluation of periodontal tissues before the beginning of surgical treatment of generalized periodontitis of II and III degree of severity and after its completion has not yet been carried out, which determined the relevance of this study. Therefore, this study aims to address this gap in the literature. The aim of the study was to evaluate the state of periodontal tissues of patients at the preoperative stage of generalized periodontitis ІІ-ІІІІ degree treatment using periodontal and hygienic indices. Materials and Methods. Analysis of periodontal indices (PMA, PBI, Rtg-index, HEC, and tooth mobility score) was performed in 39 patients with GP II degree and 21 patients with GP III degree. Assessment of oral cavity hygiene by the OHI-S index was performed in patients with GP II-III degree and compared with data from 30 practically healthy people without dental diseases. The classification of M.F. Danilevsky (1994) with the additions of I.S. Mashchenko (2002) was used to evaluate the condition of periodontal tissues. Statistical processing of the research results was carried out using the software packages for statistical analysis of data from biomedical research “Microsoft Excel” and “Statistica”. Results and Discussion. As a result of the study, it was found that the values of periodontal indices: PMA ranged from 49.90±2.28% in patients with GP II degree to 64.25±3.22% in patients with GP III degree, p<0.01; PBI in patients with GP III degree was 1.2 times lower than in patients with GP II degree (2.39±0.05 points vs. 2.86±0.07 points, p<0.01; tooth mobility in patients with GP II degree was 2.00±0.10 points and was 1.5 times lower than in patients with GP III degree (2. 98±0.13 points), p<0.01; the value of HEC in patients with GP III degree was 1.5 times higher than in patients with GP II degree (3.57±0.10 mm vs. 2.45±0.08 mm, p<0.01); the values of Rtg-index in patients with GP ranged from 2.45±0.08 points in patients with GP II degree to 1.49±0.06 points in patients with GP III degree. According to the OHI-S index, in the control group and in patients with GP II degree, the values of the analyzed parameter were 1.82±0.13 points and 2.26±0.14 points, p<0. 05, while in patients with GP III degree the value of OHI-S index (2.92±0.16 points) corresponded to poor hygiene of oral cavity and exceeded the value in the control group by 1.6 times, p<0.01, and in patients with GP II degree by 1.3 times, p1<0.01. Conclusions. Thus, the need for comprehensive treatment of GP II-III degree was emphasized by high index scores of periodontal indices, which in patients with GP III degree were significantly higher compared with similar data in patients with GP II degree, p<0.01. The assessment of the hygienic state of the oral cavity in patients of both the comparison group and patients with advanced forms of GP degree the need to strengthen and improve individual, professional and motivational measures in this cohort of subjects.

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Optimization of Preoperative Preparation in Complex Treatment of Generalized Periodontitis

Cited by 6 publications

References 4 publications

Morphometric indicators of wound bone tissue condition after surgical treatment of spontaneous periodontitis accompanied by different functional state of organism reactivity

Morphometric indicators of wound bone tissue condition after surgical treatment of spontaneous periodontitis accompanied by different functional state of organism reactivity

Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?

Index Assessment of Periodontal Tissue and Oral Hygiene of Patients at the Preoperative Stage of Treatment of Generalized Periodontitis Ii-Iii Degree

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