Optimization of prednisolone acetate-loaded chitosan microspheres using a 2³factorial design for preventing restenosis

Brain targeted oral delivery of doxycycline hydrochloride encapsulated Tween 80 coated chitosan nanoparticles against ketamine induced psychosis: behavioral, biochemical, neurochemical and histological alterations in mice

“…The present study was designed to develop novel, optimized, biodegradable, biocompatible, nontoxic and economical brain targeting drug delivery system consisting of Tween 80 coated doxycycline hydrochloride nanoparticles and studied against ketamine induced psychosis in animal models for their possible behavioral, biochemical, neurochemical and histological alterations. Being reported as a stable, nontoxic, biodegradable, biocompatible and inexpensive biopolymer potentiating brain uptake of several drugs for the management of psychiatric disorders (Mandala Rayabandla et al., 2010 ; Sarısozen et al., 2010 ; Hansraj et al., 2015 ), chitosan was selected for the present study. In order to target the brain, coating of nanoparticles was done with Tween 80, a non-ionic surfactant, owing to its brain specificity by binding with plasma Apo-E lipoprotein that mimics low density lipoproteins (LDL), which further attach with LDL receptors on brain micro vascular endothelial cells (Kreuter, 2001 ).…”

Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers

“…[26, 35,101] and PLGA [44,74,82,98,[102][103][104][105][106], or hydrophilic ones such as chitosan [25,45,56,94,[107][108][109][110][111], alginate [37,112], poly(vinylpyrrolidone) (PVP) [113,114], hydroxypropylmethylcellulose (HPMC) [69] and gelatin [50,115] are initially dissolved in organic or aqueous solvents, respectively, and then spray-dried. In the former, the main advantage is the use of solvents with low boiling point.…”

Cyclosporine A/porous quaternized chitosan microspheres as a novel pulmonary drug delivery system

“…Additionally, the DL of MS I was higher than any of the three nonporous MS (p < .05) duo to the large surface area of porous particles [38]. The lower entrapment and drug-loading efficiencies of all MS could be explained by aspiration of the smallest and lightest particles formed by the non-encapsulated free drug and the corresponding excipients during the spray-drying process [39]. Besides, the relatively low values of EE and DL could be because of low volumes of feed solution in each batch [40].…”