Optimization of Polymer Concentration for Designing of Oral Matrix Controlled Release Dosage Form

Abstract

Patient’s compliance can be enhanced by using extended release drug delivery systems which allow decreasing the number of daily doses, and helping to maintain uniform drug levels and increase the safety margin for high-potency drugs. Hydroxypropyl methylcellulose (HPMC) is the most commonly used hydrophilic polymer for the preparation of oral controlled drug delivery systems. This research was conducted with the aim of developing matrix based oral controlled release tablets for the drug diclofenac sodium using different viscosity grades of HPMC (K15M) and to compare the drug release characteristics with those of a commercial product, Voltaren® SR 100. Similarity factor (f2), values in between test formulation and marketed preparation was calculated to choose the best formulation. The release kinetics from various matrices was also studied. Increasing in polymer content reduced the rate of drug release. At the same polymer content in the matrix, the drug release was most sustained with tablets prepared using HPMC (K15M). Out of all the formulations studies, matrix tablets containing 40% of HPMC (K15M) showed comparable dissolution profile to that of the marketed preparation as indicated by a similarity factor value of (f2) 88.30%. The release of drug from marketed preparation and matrix with HPMC (K15M) 40% was found to be a diffusion drug mechanism as per Higuchi equation.

Chitosan encapsulation modulates the effect of trans-cinnamaldehyde on AHL-regulated quorum sensing activity

“…indicates the Fickian diffusion is the mechanism of CA release [61]. The similar values of the n exponent in NC (0.33) and NE (0.23) indicated that chitosan on the surface of NC did not affect the CA release behavior compared to the NE.…”

Diosgenin Loaded Polymeric Nanoparticles with Potential Anticancer Efficacy

“…This indicates that the formulation followed non-Fickian type drug release. The reason could be attributed to the increase in molecular rearrangement of polymeric chains and drug polymer interaction as the solvent diffuses in the nanoparticles [ 38 , 39 ]. Therefore, this could be useful in cancer therapy for the targeted delivery of the drug and also for the prolonged period of time [ 40 ].…”

Synthesis and Characterization of Diosgenin Encapsulated Poly-ε-Caprolactone-Pluronic Nanoparticles and Its Effect on Brain Cancer Cells

“…Since the release exponent n value in both conditions was less than 0.45, the result confirms the Fickian diffusion type of release of Diosgenin from the PCL-F68-D-NPs. Earlier, it was reported that the increase in drug-polymer interaction and molecular rearrangement of polymer chains can cause slower diffusion and release as the solvent diffuses into the nanoparticles, which is useful for targeted delivery [60,61].…”