Optimization of parodontium tissue irradiation method for fluorescent diagnostic (FD) and photodynamic therapy (PDT)

Sinyaeva, M. L.; Мамедов, А. А.; Lervkin, V. V.; Kharnas, Sergey S.; Volkova, Anna I.; Loschenov, Victor B.; Berezin, A. N.; Kiselev, Gennady L.

doi:10.1117/12.563222

Cited by 2 publications

(1 citation statement)

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“…In parallel, the common health disorder of renal failure is associated with a definite increase of blood and salivary urea level with risk of establishment of the pathological state of uremic stomatitis. The elevated rate of urea in blood and saliva is related to considerably lower distribution of non-cavitated and cavitated carious lesions, but to enhanced risk of gingival and periodontal disease [38][39][40][41][42]. We confirm the key role of secretory Ig A in non-stimulated mixed saliva as a plaque-inhibiting indicator, with suppressive activity against progression of the gingival inflammatory process.…”

Section: Discussionsupporting

confidence: 64%

Evaluation of the Gingival Health Status in Children Suffering from Some Renal Disorders

Angelova

2020

ADOH

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Salivary secretory Ig A is characterized as a considerable indicator for assessment of the risk of pathological processes affecting periodontal tissues and structures. The initiation and progression of the excretory system disorders of pyelonephritis and nephrotic syndrome correlate to the necessity of frequent hospitalizations of patients in child's age. The aim of the study is to be evaluated the gingival health status in children suffering from pyelonephritis and nephrotic syndrome. In the study are applied clinical, laboratory and statistical methods. Among the children with diagnosed nephrotic syndrome is registered moderate negative correlation between salivary sIg A and PLI, as well as moderate negative correlation between salivary sIg A and GI. The healthy representatives of the study are characterized with significant negative correlation between the indicators of salivary sIg A and PLI, as well as significant negative correlation between salivary sIg A and GI. The participants with nephrotic syndrome are characterized with moderate negative correlation between the clinical indicator of PLI and salivary pH level. In the group of children with pyelonephritis is recorded significant negative correlation between PLI and salivary pH. Among the healthy representatives is registered extremely great negative correlation between both of the indicators of PLI and salivary pH. Great negative correlation between the clinical indicator of GI and salivary pH value is ascertained among the representatives of the three groups included in the study. The lowest level of secretory sIg A is registered among the participants suffering from nephrotic syndrome. The increased concentration of salivary secretory Ig A correlates to the lower levels of the PLI and GI. The reduced level of sIg A in saliva predisposes to initiation and progression of inflammatory reactions of the gingival tissue.

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Section: Discussionsupporting

confidence: 64%

Evaluation of the Gingival Health Status in Children Suffering from Some Renal Disorders

Angelova

2020

ADOH

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Aluminum phthalocyanine nanoparticles activation for local fluorescence spectroscopy in dentistry

Золотарева

Farrakhova

Куприянова

et al. 2018

BMP

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Early diagnosis of caries and tooth enamel microcracks is of great importance for preventing the destruction of healthy tooth enamel. Inorder to detect microcracks in the enamel and pathogenic microflora foci that can cause caries, nanoform of aluminum phthalocyanine (AlPc) can be used as a marker. In a colloidal solution, the nanoparticles do not fluoresce, unlike their molecular form. To convert the particle into its molecular form, it is necessary to have a solvent or specific environment (bacteria, macrophages, etc.). That is why the hydrophobic nanoparticles of aluminum phthalocyanine (nAlPc) can act as markers for detecting hidden pathogenic microflora during fluorescent diagnostics. Further reduction of the diagnosis time and increase the efficiency can be achieved by using biologically compatible surfactants as additional activators of nAlPc.In order to carry out local fluorescence spectroscopy of enamel microcracks and pathogenic microflora foci on the enamel surface, a model compound containing surfactants, auxiliary components and nAlPc colloid at a concentration of 10 mg/l was prepared.Studies on the interaction of the model compound with nAlPc and Protelan MST-35 with tooth enamel ex vivo have shown this surfactant to be a promising auxiliary activator of the nanoparticles, allowing conducting local fluorescence spectroscopy of the tooth enamel surface 3 min after application. In addition, statistical processing of the results showed the effectiveness of using the model compound for local fluorescence spectroscopy of the enamel surface in order to detect the enamel microcracks and the pathogenic microflora accumulation foci that can lead to the development of a cariogenic process.

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Optimization of parodontium tissue irradiation method for fluorescent diagnostic (FD) and photodynamic therapy (PDT)

Cited by 2 publications

References 4 publications

Evaluation of the Gingival Health Status in Children Suffering from Some Renal Disorders

Evaluation of the Gingival Health Status in Children Suffering from Some Renal Disorders

Aluminum phthalocyanine nanoparticles activation for local fluorescence spectroscopy in dentistry

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