Optimization of olive leaf extract obtained by ultrasound-assisted extraction with response surface methodology

Şahın, Selin; Şamlı, Rüya

doi:10.1016/j.ultsonch.2012.07.029

Cited by 317 publications

(188 citation statements)

References 26 publications

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“…For this reason, hydro-alcoholic mixtures, especially ethanol, are the solvent systems most suitable for extraction due to the different polarities of the phenolic compounds and the acceptability of this system for human consumption [36]. In this context, Sahin andŞamlı [37] reported that the best extraction yield of phenolic compounds was achieved using a 50%-50% ethanol-water mixture. These authors point to a synergistic effect among the solvents, since water acts as a swelling agent of the plant matrix, increasing the contact surface, while ethanol induces the rupture of the bond between the solutes and the matrix.…”

Section: Effect Of the Solventmentioning

confidence: 99%

Ultrasound Assisted Extraction for the Recovery of Phenolic Compounds from Vegetable Sources

Medina-Torres¹,

et al. 2017

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Vegetable sources and agro-industrial residues represent an important source of phenolic compounds that are useful in a wide range of applications, especially those with biological activities. Conventional techniques of phytochemical extraction have been associated with a high consumption of organic solvents that limits the application of bioactive extracts, leading to the implementation of novel extraction technologies using mechanisms such as Ultrasound Assisted Extraction (UAE). In the present review, an analysis of the involved variables in the extraction yield of phenolic compounds through UAE is presented, highlighting the advantages of this technology based on the results obtained in various optimized studies. A comparison with other technologies and a proposal of its possible application for agro industrial residues as raw material of phenolic compounds is also indicated. Finally, it is concluded that UAE is a technology that is placed within the area of Sustainable Chemistry since it promotes the use of renewable raw materials through the extraction of phenolic compounds, implementing the substitution of organic solvents with solvents that do not present toxic effects, lowering the energy consumption when compared to conventional methods and minimizing process times and temperatures, which is useful for the extraction of thermo-labile compounds.

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Section: Effect Of the Solventmentioning

confidence: 99%

Ultrasound Assisted Extraction for the Recovery of Phenolic Compounds from Vegetable Sources

Medina-Torres¹,

et al. 2017

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“…Previous studies showed that temperature, time and amount of solvent were the main parameters affecting the extraction yield from different sources (Li et al, 2012;Goula, 2013;Minjares-Fuentes et al, 2014). These parameters also had a significant influence on the endogenous bioactive compounds, such as certain from the TPC (Rodrigues et al, 2008;Ghafoor et al, 2009;Wang et al, 2013;Sahin and Samli, 2013;Chanioti et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Optimization of mango seed kernel oil extraction using response surface methodology

Mas’ud

Mahendradatta

Laga

et al. 2017

OCL

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-Response surface methodology (RSM) was applied to study the optimum condition of mango seed kernel oil (MSKO) extraction with n-hexane. In the present paper, for the first time, we provide an optimal condition of MSKO extraction to obtain the maximum of yield, total phenolic content (TPC) and vitamin E. The experiment was conducted using central composite design (CCD) consisted of twenty experimental points including six replicates of center points to study the effect of three independent variables: temperature, time and amount of n-hexane on dependent variables. Data were analyzed using Design-Expert 10 software. The result showed that the optimum condition of MSKO extraction were 54.19°C, 5.24 h and 224.23 mL of n-hexane. In this condition MSKO have yield of 7.03%, TPC of 67.77 mg GAE/g oil and vitamin E of 141.22 mg/L. These results suggest that MSKO has potential as raw materials of food products oil-based and as a natural antioxidant of functional food and for use in food processing.Keywords: mango seed kernel oil / oil extraction / total phenolic content / vitamin E / response surface methodology Résumé -Optimisation de l'extraction d'huile de noyau de mangue à l'aide de la méthodologie RSM.La méthodologie Response surface methodology (RSM) a été appliquée pour définir les conditions optimales d'extraction de l'huile de noyau de mangue avec du n-hexane. Dans le présent article, pour la première fois, est proposée une condition optimale d'extraction de l'huile de noyau de mangue afin d'optimiser le rendement, la teneur en phénols (total phenolic content ou TPC) et en vitamine E. L'expérience a été réalisée en utilisant plan d'expériences composite centré de vingt points expérimentaux avec six répétions de points centraux pour étudier l'effet de trois variables indépendantes : température, temps et quantité de n-hexane sur des variables dépendantes. Les données ont été analysées à l'aide du logiciel Design-Expert 10. Le résultat a montré que les conditions optimales d'extraction de l'huile de noyau de mangue étaient 54,19°C, 5,24 h et 224,23 ml de nhexane. Dans ces conditions, le rendement est de 7,03 %, la teneur TPC de 67,77 mg GAE/g d'huile et la concentration en vitamine E de 141,22 mg/L. Ces résultats soulignent le potentiel de l'huile de noyau de mangue en tant que matière première de produits alimentaires à base d'huile et en tant qu'antioxydant naturel des aliments fonctionnels et pour la transformation des aliments.

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“…Many reports have been published on the application of ultrasounds for the extraction of secondary metabolites from plants (Huang et al 2009;Zhang et al 2011;Tabaraki & Nateghi 2011;Sahin & Samli 2013) but there are no reports on UAE of total phenolics and flavonoids from walnut leaves.…”

Section: Introductionmentioning

confidence: 99%

Optimization of ultrasound-assisted hydroalcoholic extraction of phenolic compounds from walnut leaves using response surface methodology

Nour

Trandafir

Cosmulescu

2016

Pharmaceutical Biology

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Context Walnut leaves are highly appreciated for their pharmacological effects and therapeutic properties which are mainly attributed to their high content of phenolic compounds. Objective This study optimizes ultrasound assisted hydroalcoholic extraction (UAE) of phenolic compounds from dried walnut leaves by the maximization of total phenolics content (TPC) and total flavanoids content (TFC) of the extracts. Materials and methods Optimal conditions with regard to ethanol concentration (X 1 : 12.17-95.83% v/v), extraction time (X 2 : 8.17-91.83 min) and liquid-to-solid ratio (X 3 : 4.96-25.04 v/w) were identified using central composite design combined with response surface methodology. A high-performance liquid chromatography method with diode-array detection was used to quantify phenolic acids (gallic, vanillic, chlorogenic, caffeic, syringic, p-coumaric, ferulic, sinapic, salicylic, ellagic and trans-cinnamic), flavonoids (catechin, epicatechin, rutin, myricetin and quercetin) and juglone in the extracts. Results Liquid-to-solid ratio and ethanol concentration proved to be the primary factors affecting the extraction efficiency. The maximum predicted TPC, under the optimized conditions (61% ethanol concentration, 51.28 min extraction time and 4.96 v/w liquid-to-solid ratio) was 10125.4 mg gallic acid equivalents per liter while maximum TFC (2925 mg quercetin equivalents per liter) occurred at 67.83% ethanol concentration, 4.96 v/w liquid-to-solid ratio and 49.37 min extraction time. High significant correlations were found between antioxidant activity and both TPC (R 2 ¼ 0.81) and TFC (R 2 ¼ 0.78). Discussion and conclusion Extracts very rich in polyphenols could be obtained from walnut leaves by using UAE, aimed at preparing dietary supplements, nutraceuticals or functional food ingredients. ARTICLE HISTORY

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Optimization of olive leaf extract obtained by ultrasound-assisted extraction with response surface methodology

Cited by 317 publications

References 26 publications

Ultrasound Assisted Extraction for the Recovery of Phenolic Compounds from Vegetable Sources

Ultrasound Assisted Extraction for the Recovery of Phenolic Compounds from Vegetable Sources

Optimization of mango seed kernel oil extraction using response surface methodology

Optimization of ultrasound-assisted hydroalcoholic extraction of phenolic compounds from walnut leaves using response surface methodology

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