Optimization of Mixing Ratio of Mulberry Leaf, Mulberry Fruit, and Silkworm for Amelioration of Metabolic Syndrome

Abstract

The aim of this study was optimized mixing ratio of mulberry leaf, mulberry fruit, and silkworm for amelioration of the metabolic syndrome by using response surface method (RSM). Methods: Antioxidant, antidiabetic and antihypertensive activities of fifteen mixed powder of mulberry leaf, mulberry fruit, and silkworm by RSM were measured as indicators of metabolic syndrome. Results: The optimal mixing ratio of mulberry leaves, mulberry fruits, and silkworm with the greatest antioxidant, antidiabetic and antihypertensive activities was as follows: 2.5890 of mulberry leaf (A), 0.1222 of mulberry fruit (B), 2.9999 of silkworm (C). At this time, it was predicted that the total polyphenol content was estimated to be 185.51 tannic acid equivalent mg/g, 1, 1-diphenyl-2-picrylhy drazyl radical scavenging activity 84.77%, 1-deoxynojirimycin content 415.66 mg/100 g, α-glucosidase inhibitory activity 64.31%, γ-aminobutyric acid content 267.77 mg/100 g, potassium content 1,899.11 mg/100 g, and angiotensin-converting-enzyme inhibitory activity was estimated to be 73.78%. Conclusions: It was concluded that the significant effect of the mulberry leaf, mulberry fruit, and silkworm on the metabolic syndrome-related biological activity indices (antioxidant activity, antidiabetic activity and antihypertensive activity) was as follows: 2.5890 of mulberry leaf (A), 0.1222 of mulberry fruit (B), 2.9999 of silkworm (C).

Foliar Spraying of 6-Benzylaminopurine Promotes Growth and Flavonoid Accumulation in Mulberry (Morus alba L.)

“…Therefore, the Ministry of Health of China has listed mulberry leaves as a plant resource that is "a source of both medicine and food". Mulberry leaves have been developed into many foods, such as mulberry leaf tofu (Kim et al 2008), mulberry leaf biscuits (Monika et al 2016), mulberry leaf tea (Sheng et al 2018) and mulberry leaf dishes (Kim et al 2018). Among them, mulberry leaf tea is the most popular mulberry leaf food.…”

Analysis of Research Trends in Papers Published in the Journal of Korean Medicine for Obesity Research: Focused on 2010-2019

“…단미처방으로는 백출 80,82,85,86) 이 4회 사용되어 가장 빈 도가 높게 나타났으며 금은화 77,82,86) , 황련 77,82,86) 이 3회, 어 성초 82,86) , 황금 82,86) , 부자 89,94) 가 2회 사용되었다. 그 외 황 기 83) , 연잎-연근 혼합물 81) , 산사나무 유래물 87) , 육계 89) , 갈 근 89) , 백두옹 93) , 생강 94) , 커큐민 94) , 천문동 96) , 도라지 97) , 더 81,84,86,96,97,99,101,102) , 당대사와 에너지 대사에 대한 연구가 8편 82,83,85,89,92,95,96,102) , 항염증효과, 항산화효과, 유해균 억제효과 등 세포보호효과에 대한 연구가 총 16 편 [77][78][79][80]84,[86][87][88]90,…”