Optimization of Magnetic Nanoparticles for Magnetic Particle Imaging

Effective particle magnetic moment of multi-core particles

“…The FeraSpin R particles are carboxydextran coated multicore particles, i.e. the multi-core particles consist of clusters composed of smaller nanocrystals of about 5-8 nm [10,11]. The multi-core particles exhibit a size distribution with the smallest one comprising only one nanocrystal per multi-core particle and the larger ones containing multiple nanocrystals per multi-core particle.…”

Hydrodynamic and magnetic fractionation of superparamagnetic nanoparticles for magnetic particle imaging

“…Therefore, the isolation of this large sized particle population responsible for the high MPI signal is of great interest. Several attempts were made to separate Resovist s magnetically [5,6] and characterize the obtained fractions with regard to MPI performance [7][8][9]. Furthermore, asymmetric flow field-flow fractionations (A4F) were performed to gain insight into the distribution of hydrodynamic sizes of Resovist s as this method gently produces fractions of narrow hydrodynamic size distribution and permits highly reproducible and accurate size evaluations [4,10,11].…”

Application of magnetic field hyperthermia and superparamagnetic iron oxide nanoparticles to HIV-1-specific T-cell cytotoxicity

“…[33][34][35] Resovist is a 60 nm carboxydextrancoated SPION with superior cellular uptake properties [36][37][38] and a higher heating capability, or calculated intrinsic loss power, than other SPIONs, 39 such as clinically available Endorem (sample VII). 40 However, since Resovist is now commercially unavailable, Feraspin R, a closely related SPION formula with very similar properties to Resovist, 41 was employed to study the feasibility of using MFH to enhance CTL killing of HIV-infected cells by two distinct mechanisms. The thermotherapeutic heat generated in cloned, Feraspin R-loaded autologous patient CTLs through alternating magnetic field exposure could either lead to the death of CTL-bound antigen-expressing target cells through direct thermal ablation or enhance their cytolytic CTL activity when these cells are adoptively transferred back into the patient.…”