Abstract:L-asparaginase, an important biopharmaceutical, has been a boon to cancer patients, especially for the therapeutic treatment of acute lymphoblastic leukemia. However, asparaginase formulations from E. coli and Erwinia species currently being used are associated with potential side effects causing hindrances towards a successful therapeutic treatment. Therefore, optimization and production of asparaginase from varied microbial sources has been the aim of several studies to overcome the hypersensitive and toxico… Show more
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