Optimization of headspace solid-phase microextraction for analysis of β-caryophyllene in a nanoemulsion dosage form prepared with copaiba (Copaifera multijuga Hayne) oil

Effects of the oral treatment with Copaifera multijuga oil on reproductive performance of male Wistar rats

“…Veiga-Júnior et al (1997) identified terpene compounds, and these compounds are mixtures of sesquiterpenes (caryophyllene and -bisabolene). Similar results were published by Dias et al (2012), and in our study, we have also found similar components. The great complexity of inputs of natural origin led the World Health Organization to consider and accept the chromatographic fingerprint as a more robust way to analyze the quality of natural products, focusing on the qualitative and systematic comparison of individual peaks in different samples.…”

Development of a larvicidal nanoemulsion with Copaiba (Copaifera duckei) oleoresin

“…The development of a nanoemulsion with copaiba oleoresin is also important for the stability of this sesquiterpene. A reduced degradation of caryophyllene from a nanoemulsion was observed with copaiba oleoresin dispersed through the internal phase after acid hydrolysis, exposure to UV-A irradiation, oxidative (H 2 O 2 ) and thermolytic (60 o C) conditions, when compared to beta-caryophyllene content after exposure to same conditions (Dias et al, 2012).…”

“…Mean droplet analysis revealed droplets around 120 and 140 nm (Dias et al, 2012). Copaiba oleoresins are mainly constituted by sesquiterpene hydrocarbons, which often correspond to almost 90% of the total relative composition of the oil, being beta-caryophyllene considered the main constituent.…”

“…Diterpenes are also found in smaller quantities in copaiba oleoresin (Sousa et al, 2011). Beta-caryophyllene has also been considered an important substance involved in the pharmacological activities of Copaifera spp., and is considered a phytochemical marker and standard for quantification studies (Lima et al, 2011;Dias et al, 2012). The development of a nanoemulsion with copaiba oleoresin is also important for the stability of this sesquiterpene.…”

Production of Phytotherapeutics in Brazil: History, Problems and Perspectives

“…O seuà leoà e aà e ele teà pa aà aà u aà deà feridas, porque nem mesmo restam vestígios deà i at izes ,à dizà eleà p gi aà .à Ga ielà Soares de Sousa 60 oà o side avaà u à leoà sa tíssi o à ta à usadoà pa aà f ialdades,à dores de barriga e po tadasà deà f io à p gi aà 164). Para Gândavo 49 ,antiinflamatória [261][262][263][264][265][266][267] , antileishmania [268][269][270][271] , na endometriose 272 , na urolitíase 273 , na acne 274 , na psoríase 275 , no controle do mosquito Aedes aegypti [276][277][278] , no controle de ácaros 279 e em infecções ginecológicas. 280 O óleo da copaíba também reduz os níveis séricos de ureia e creatinina em ratos submetidos à síndrome de isquemia e reperfusão.…”