Optimization of curcumin nanofibers as fast dissolving oral films prepared by emulsion electrospinning via central composite design

Kamali, Hossein; Farzadnia, Parisa; Movaffagh, Jebraeil; Abbaspour, Mohammadreza

doi:10.1016/j.jddst.2022.103714

Cited by 11 publications

(4 citation statements)

References 62 publications

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“…Hydrophilic polymers serve to create films due to their ability to facilitate rapid disintegration, provide a pleasant mouthfeel, and contribute desirable mechanical properties to the films (Maskare et al, 2023). To achieve the favorite film characteristics, such as hydrophilicity, adaptability, mouthfeel, and stability, the polymer is utilized only in a mixture by others (Kamali et al, 2022). The tensile strength of polymers varies depending on the kind and quantity of films used.…”

Section: Film Forming Polymersmentioning

confidence: 99%

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Oral Disintegrating Films: A Review

Raihan,

Wafa,

Zhakfar

et al. 2024

JNSR

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The oral route stands out as a preferred method for drug administration due to its cost-effectiveness and ease, contributing to enhanced patient compliance. Some individuals, particularly the geriatric and pediatric populations, encounter difficulties swallowing conventional tablets and hard gelatin capsules. To address this, oral disintegrating drug delivery systems are established as substitutes for tablets, capsules, and syrups. Notably, fast-dissolving oral thin films offer a practical solution for patients such as those in pediatric, bedridden, or developmentally disabled categories, as well as the geriatric population who struggle with a tablet or hard gelatin capsule ingestion. This innovative dosage form involves the creation of thin films consuming water-soluble polymers that quickly disintegrate and dissolve in the mouth cavity. It serves as a substitute stage for those particles that undergo significant metabolism of drugs in the liver. This study provides an overview of numerous dosage form-formulations, preparation approaches, and quality control measures related to fast-disintegrating films.

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Section: Film Forming Polymersmentioning

confidence: 99%

“…At a minimum, 45% of the polymer by weight must exist based on the dry film's total weight; however, 60%-65% is recommended to provide the required characteristics. Notably, as polymer film bases' molecular weight rises, the polymer disintegration rate lowers (Kamali et al, 2022).…”

Section: Film Forming Polymersmentioning

confidence: 99%

Oral Disintegrating Films: A Review

Raihan,

Wafa,

Zhakfar

et al. 2024

JNSR

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“…Alternatives for the administration of the natural active compound have been explored, such as gels [29][30][31][32], ointments [33][34][35], and mainly orally disintegrating films [1,5,36]. Generally, oral films are developed from natural polymers [1,3,[36][37][38][39], and their characteristics, such as disintegration time, stability of the active compounds, and biological activities, among others, are determined since they can be affected by several factors.…”

Section: Introductionmentioning

confidence: 99%

Oral Films Printed with Green Propolis Ethanolic Extract

Remedio,

Garcia,

Rochetti

et al. 2024

Polymers

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Oral film (OF) research has intensified due to the effortless administration and advantages related to absorption in systemic circulation. Chitosan is one of the polymers widely used in the production of OFs; however, studies evaluating the maintenance of the active principles’ activity are incipient. Propolis has been widely used as an active compound due to its different actions. Printing techniques to incorporate propolis in OFs prove to be efficient. The objective of the present study is to develop and characterize oral films based on chitosan and propolis using printing techniques and to evaluate the main activities of the extract incorporated into the polymeric matrix. The OFs were characterized in relation to the structure using scanning and atomic force electron microscopy; the mechanical properties, disintegration time, wettability, and stability of antioxidant activity were evaluated. The ethanolic extract of green propolis (GPEE) concentration influenced the properties of the OFs. The stability (phenolic compounds and antioxidant activity) was reduced in the first 20 days, and after this period, it remained constant.

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“…Electrospinning (or electrostatic spinning), initially a textile method, is entering pharmaceutics, particularly the development of ASDs of poorly water-soluble drugs (in many publications, ASDs are called nano composites or molecular composites ( Wang, et al, 2020 ; Kamali, et al, 2022 ; Liu, et al, 2022 ). This trend has a close relationship to the following capabilities of electrospinning: 1) Multiple components can be treated in a blended manner or a certain organized manner (such as core–sheath or side-by-side), provided that they can be co-dissolved into a certain solvent or solvent mixture ( Zhang, et al, 2021 ; Zhu, et al, 2022c ; Li, et al, 2022 ; Xu, et al, 2023a ); 2) All kinds of nanostructures can be created in a single-step and in a forward straight manner, which holds great promises for productions on a large scale.…”

Section: Introductionmentioning

confidence: 99%

The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions

Wang

Lü

Yang

et al. 2023

Front. Mol. Biosci.

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Based on a working fluid consisting of a poorly water-soluble drug and a pharmaceutical polymer in an organic solvent, electrospinning has been widely exploited to create a variety of amorphous solid dispersions However, there have been very few reports about how to prepare the working fluid in a reasonable manner. In this study, an investigation was conducted to determine the influences of ultrasonic fluid pretreatment on the quality of resultant ASDs fabricated from the working fluids. SEM results demonstrated that nanofiber-based amorphous solid dispersions from the treated fluids treated amorphous solid dispersions exhibited better quality than the traditional nanofibers from untreated fluids in the following aspects: 1) a straighter linear morphology; 2) a smooth surface; and 3) a more evener diameter distribution. The fabrication mechanism associated with the influences of ultrasonic treatments of working fluids on the resultant nanofibers’ quality is suggested. Although XRD and ATR–FTIR experiments clearly verified that the drug ketoprofen was homogeneously distributed all over the TASDs and the traditional nanofibers in an amorphous state regardless of the ultrasonic treatments, the in vitro dissolution tests clearly demonstrated that the TASDs had a better sustained drug release performance than the traditional nanofibers in terms of the initial release rate and the sustained release time periods.

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Optimization of curcumin nanofibers as fast dissolving oral films prepared by emulsion electrospinning via central composite design

Cited by 11 publications

References 62 publications

Oral Disintegrating Films: A Review

Oral Disintegrating Films: A Review

Oral Films Printed with Green Propolis Ethanolic Extract

The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions

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