Optimization of chitosan–tapioca starch composite as polymer in the formulation of gingival mucoadhesive patch film for delivery of gambier (Uncaria gambir Roxb) leaf extract

Miksusanti,; Fithri, Najma Annuria; Herlina, .; Wijaya, Dina Permata; Taher, Tarmizi

doi:10.1016/j.ijbiomac.2019.12.086

Cited by 29 publications

(12 citation statements)

References 13 publications

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“…As in other studies evaluating the diffusion of the active substance through the Franz cell, the release was directly proportional to the diffusion pace, being maximum at the final phase [ 44 ]. In a study evaluating the release of blue methylene from polymer films, samples were collected at 5, 10, 15, 30 min, 1 h, 2 h, 4 h, 6 h. The percentage of yielding was incrementing alongside the increase in time [ 43 ].…”

Section: Resultsmentioning

confidence: 76%

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Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos

et al. 2023

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Taraxaci folium and Matricariae flos plant extracts contain a wide range of bioactive compounds with antioxidant and anti-inflammatory effects. The aim of the study was to evaluate the phytochemical and antioxidant profile of the two plant extracts to obtain a mucoadhesive polymeric film with beneficial properties in acute gingivitis. The chemical composition of the two plant extracts was determined by high-performance liquid chromatography coupled with mass spectrometry. To establish a favourable ratio in the combination of the two extracts, the antioxidant capacity was determined by the method of reduction of copper ions Cu2+ from neocuprein and by reduction of the compound 1.1-diphenyl-2-2picril-hydrazyl. Following preliminary analysis, we selected the plant mixture Taraxaci folium/matricariae flos in the ratio of 1:2 (m/m), having an antioxidant capacity of 83.92% ± 0.02 reduction of free nitrogen radical of 1.1-diphenyl-2-2picril-hydrazyl reagent. Subsequently, bioadhesive films of 0.2 mm thickness were obtained using various concentrations of polymer and plant extract. The mucoadhesive films obtained were homogeneous and flexible, with pH ranging from 6.634 to 7.016 and active ingredient release capacity ranging from 85.94–89.52%. Based on in vitro analysis, the film containing 5% polymer and 10% plant extract was selected for in vivo study. The study involved 50 patients undergoing professional oral hygiene followed by a 7-day treatment with the chosen mucoadhesive polymeric film. The study showed that the film used helped accelerate the healing of acute gingivitis after treatment, with anti-inflammatory and protective action.

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Section: Resultsmentioning

confidence: 76%

“…The pharmaceutical form devised was of the matrix type. Its configuration comprises the active substance, the polymer and the excipients mixed together into a unitary product [ 44 ].…”

Section: Methodsmentioning

confidence: 99%

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Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos

et al. 2023

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“…Porous carrier is added with 2% gelatin solution as a binder in the granulation process. The binder provides adhesion to the mass of the powder during granulation 12 . Resulting organoleptic of solid SNEDDS was smooth, with no apparent discoloration and clumps.…”

Section: Preparation Of Mefenamic Acid Solid Sneddsmentioning

confidence: 99%

“…Factorial design method facilitates the determination of influence from each and interaction between factors on the responses yielded 10,11 . This method will minimize the number of trials to obtain the optimum formula of solid SNEDDS 12 . This research will delve further on the effects of solid porous carriers as potential aids to increase the efficacy and reduce side effect of mefenamic acid in therapeutical uses.…”

Section: Introductionmentioning

confidence: 99%

Solid Self Nano Emulsifying Drug Delivery System (Solid Snedds) of Mefenamic Acid: Formula Optimization Using Aerosil®-200 and Avicel® Ph-101 With Factorial Design

Mardiyanto¹,

Untari²,

Anjani³

et al. 2020

Int Res J Pharm

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Self-nanoemulsifying drug delivery system (SNEDDS) is capable of enhancing the solubility of class II BCS drugs with low solubility in water such as mefenamic acid. This system facilitates the process of solubilization to spontaneously occur in the digestive tract with little agitation. Solid SNEDDS is a form of SNEDDS solidification developed to overcome the stability problems which inhibits SNEDDS ease of use. Solid SNEDDS of mefenamic acid was performed using adsorption method on porous carriers aerosil ® -200 and avicel ® PH-101. Factorial design was utilized to determine the influence of carrier and proportion of carrier to liquid form of SNEEDS. The acquired solid SNEDDS retained excellent drug content yield with a value of 100.355% along with favorable good flow and compressibility properties. Morphology analysis with SEM indicates the porous carrier was capable in completely adsorbing SNEDDS on the surface while maintaining the physical form. Solid SNEDDS was able to significantly increase the dissolution of mefenamic acid which can be seen from higher percent dissolution efficiency values (43.925 ± 0.5) % compared with generic tablets (17.865 ± 0.058 )% and capsules containing pure mefenamic acid (9.396 ± 0.009)%. Analysis of stability using various temperatures demonstrated the ability of solid SNEDDS to protect the content of mefenamic acid leading to better stability. Additionally, FTIR analysis did not show any interaction between the optimum formula components of solid SNEDDS. These results conclude that aerosil ® -200 and avicel ® PH-101 was able to act as a solid porous carrier of SNEDDS while simultaneously improving dissolution and stability.

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A novel phenolic compounds delivery system: Oral films with extract from camu‐camu industrial residue

Lourenço

Garcia

Borges

et al. 2022

J of Applied Polymer Sci

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Oral films perform promising alternatives to traditional oral delivery systems to carry and deliver bioactive compounds directly into the oral cavity. The objective of this work was to produce and evaluate oral films based on carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC) and pregelatinized starch incorporated with ethanolic extract from camu-camu industrial residue (EECCIR). Although all films can be ingested without causing irritation to the oral mucosa, due to near-neutral surface pH, the starchbased oral films with and without the addition of EECCIR showed reduced tensile strength (5.48 ± 0.97 MPa) indicating inferior mechanical properties to films based on CMC and HPMC. The CMC films, in addition to shorter disintegration time (50 ± 5 s), showed faster release, about 70% of phenolic compounds in 10 min and 100% in 30 min. As for the release profile, the application of the Korsmeyer and Peppas and Peppas and Sahlin models allowed to better understand the mechanisms involved in the release of phenolic compounds. Although all three oral film formulations can be used as carriers of active compounds from the ethanolic extract of the camu-camu residue, the oral films based on CMC incorporated with EECCIR showed greater potential.

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Optimization of chitosan–tapioca starch composite as polymer in the formulation of gingival mucoadhesive patch film for delivery of gambier (Uncaria gambir Roxb) leaf extract

Cited by 29 publications

References 13 publications

Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos

Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos

Solid Self Nano Emulsifying Drug Delivery System (Solid Snedds) of Mefenamic Acid: Formula Optimization Using Aerosil®-200 and Avicel® Ph-101 With Factorial Design

A novel phenolic compounds delivery system: Oral films with extract from camu‐camu industrial residue

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