Optimization of carotenoids production by Rhodotorula mucilaginosa (MTCC-1403) using agro-industrial waste in bioreactor: A statistical approach

Sharma, Rajan; Ghoshal, Gargi

doi:10.1016/j.btre.2019.e00407

Cited by 89 publications

(75 citation statements)

References 25 publications

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“…However, they are similar to the carotenoids-specific production obtained by optimization of Rh. mucilaginosa growth in diverse agro-industrial wastes (Sharma and Ghoshal 2020). At AW and 30% AE, although Rh.…”

Section: Carotenoid Production By Rh Mucilaginosamentioning

confidence: 97%

“…Several studies have demonstrated the feasibility of producing carotenoids from low-cost substrates (Kaur et al 2019;Sharma and Ghoshal 2020;Urnau et al 2019). In this work, we explore the production of carotenoids, in particular, torulene and torularhodin, by a strain of Rhodotorula mucilaginosa using different medium derived from alperujo as cheap substrates.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of olive mill waste as substrate for carotenoid production by Rhodotorula mucilaginosa

Ghilardi

Negrete

Carelli

et al. 2020

Bioresour. Bioprocess.

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The “alperujo” is a waste from the olive oil industry with great potential for valorization. It has a high organic load, with the presence of valuable compounds such as biophenols and sugars. The use of this waste can be thought of as a biorefinery from which different compounds of high added value can be obtained, whether they are present in the “alperujo” such as biophenols or can be generated from the “alperujo”. Therefore, the production of carotenoids by Rhodotorula mucilaginosa was evaluated using the liquid fraction of ‘alperujo’ (Alperujo Water, AW) or an aqueous extract (AE) of “alperujo” at different concentrations (5, 10, 20 and 30% w/V) as substrates. The AEs had an acidic pH, a total sugar concentration ranging from 1.6 to 7.6 g/L, a polyphenols content from 0.4 to 2.9 g/L and a significant amount of proteins (0.5–3 g/L). AW is similar in composition as 30% AE, but with a higher amount of total sugars. Rh. mucilaginosa was able to grow at the different mediums with consumption of glucose and fructose, a reduction in protein content and alkalinization of the medium. Maximum total carotenoid production (7.3 ± 0.6 mg/L) was achieved at AW, while the specific production was higher when the yeast grew at AW or at 30% AE (0.78 ± 0.06 and 0.73 ± 0.10 mg/g of biomass, respectively). Torulene and torularhodin were the main carotenoids produced. Polyphenol content did not change; thus, it is still possible to recover these compounds after producing carotenoids. These results demonstrate the feasibility of using alperujo-based mediums as cheap substrates to produce torularhodin and torulene and to include this bioprocess as a step in an integral approach for alperujo valorization.

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Section: Carotenoid Production By Rh Mucilaginosamentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Evaluation of olive mill waste as substrate for carotenoid production by Rhodotorula mucilaginosa

Ghilardi

Negrete

Carelli

et al. 2020

Bioresour. Bioprocess.

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“…trispora mold [ 28 ]. Efficient producers of microbial β-carotene also include the yeast Rhodotorula glutinis [ 6 , 29 ], Rhodotorula mucilaginosa [ 30 ], and Sporidiobolus pararoseus [ 31 , 32 ].…”

Section: Characteristics Of Some Fungal Carotenoidsmentioning

confidence: 99%

Carotenoids and Some Other Pigments from Fungi and Yeasts

et al. 2021

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Carotenoids are an essential group of compounds that may be obtained by microbiological synthesis. They are instrumental in various areas of industry, medicine, agriculture, and ecology. The increase of carotenoids’ demand at the global market is now essential. At the moment, the production of natural carotenoids is more expensive than obtaining their synthetic forms, but several new approaches/directions on how to decrease this difference were developed during the last decades. This review briefly describes the information accumulated until now about the beneficial effects of carotenoids on human health protection, their possible application in the treatments of various diseases, and their use in the food and feed industry. This review also describes some issues that are linked with biotechnological production of fungal and yeasts carotenoids, as well as new approaches/directions to make their biotechnological production more efficient.

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“…In addition, industrial wastewaters are successfully used for production of phycocyanins and carotenoid pigments by microalgae (Singh et al, 2019;Arashiro et al, 2020). Intracellular carotenoids (β-carotene, γ-carotene, torulene, and torularhodin) from Rhodotorula species have been produced by using different agro-industrial byproducts as sugarcane bagasse, wheat bran, rice bran, silage, whey, raw glycerol, corn steep liquor, sugarcane molasses, waste chicken feathers, fruit waste extract, and many others (Sharma and Ghoshal, 2019;Korumilli et al, 2020). These pigments could have applications in food and feed as well as in health, pharmaceutical products and cosmetics, generating a market value expected to reach over $2.0 billion by 2022 (Elfeky et al, 2019;Tang et al, 2019).…”

Section: Microbial Pigment Production Using Agro-industrial Byproductsmentioning

confidence: 99%

Natural Pigments of Microbial Origin

Pailliè-Jiménez

Stincone

Brandelli

2020

Front. Sustain. Food Syst.

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The world demands new solutions and products to be used as dyes for industrial applications. Microbial pigments represent an eco-friendly alternative as they can be produced in large amounts through biotechnological processes and do not present environmental risks, as they are easily decomposable. Moreover, some of these metabolites are recognized for their biological activities, which qualify them for potential uses as food colorants and nutraceuticals, protecting against degenerative diseases related with oxidative stress. Because of their genetic simplicity as compared with plants, microorganisms may be a better source to understand biosynthetic mechanisms and to be engineered for producing high pigment yields. Despite the origin of the pigmented microorganism, it seems very important to develop protocols using organic industrial residues and agricultural byproducts as substrates for pigment production and find novel green strategies for rapid pigment extraction. This review looks for the most recent studies that describe microbial pigments from microalgae, fungi, and bacteria. In particular, the underexploited tools of omics science such as proteomics and metabolomics are addressed. The use of techniques involving mass spectrometry, allows to identify different protein and metabolite profiles that may be associated with a variety of biotechnologically-relevant pathways of pigment synthesis.

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Optimization of carotenoids production by Rhodotorula mucilaginosa (MTCC-1403) using agro-industrial waste in bioreactor: A statistical approach

Abstract: Graphical abstract

Cited by 89 publications

References 25 publications

Evaluation of olive mill waste as substrate for carotenoid production by Rhodotorula mucilaginosa

Evaluation of olive mill waste as substrate for carotenoid production by Rhodotorula mucilaginosa

Carotenoids and Some Other Pigments from Fungi and Yeasts

Natural Pigments of Microbial Origin

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