Optimization of Biodegradable PLA/PCL Microspheres Preparation as Controlled Drug Delivery Carrier

Hakim, Surahman; Kusumasari, Findi Citra; Budianto, Emil

doi:10.1016/j.matpr.2019.08.156

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…Synthetic polymers widely used for tissue engineering are aliphatic polyesters such as polyglycolic acid, polylactic acid, and polycaprolactone [ 9 ] and their copolymers [ 57 ]. Synthetic polymers scaffolds possess the advantages of versatile fabrication with a broad range of degradation rates and mechanical properties in contrast with natural polymers due to their composition, the copolymer ratio, and the interactions of their polymeric side chains.…”

Section: Biomaterials Scaffoldsmentioning

confidence: 99%

“…HA can be an outstanding drug delivery carrier for numerous therapeutic agents as a result of its high stability, bioactivity, biocompatibility, and lack of toxicity [ 63 ]. In addition, biodegradable polymers have wide usage as drug delivery systems due to their biodegradability and biocompatibility, and, among them, aliphatic polyester (PLA), proteins (collagen, gelatin) or polysaccharides (alginate, chitosan) have the ability to extend the releasing of drugs from some days till some months [ 57 , 64 , 65 , 66 ].…”

Section: Drug Deliverymentioning

confidence: 99%

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Advances in Osteoporotic Bone Tissue Engineering

Codrea

Croitoru

Baciu

et al. 2021

JCM

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The increase in osteoporotic fracture worldwide is urging bone tissue engineering research to find new, improved solutions both for the biomaterials used in designing bone scaffolds and the anti-osteoporotic agents capable of promoting bone regeneration. This review aims to report on the latest advances in biomaterials by discussing the types of biomaterials and their properties, with a special emphasis on polymer-ceramic composites. The use of hydroxyapatite in combination with natural/synthetic polymers can take advantage of each of their components properties and has a great potential in bone tissue engineering, in general. A comparison between the benefits and potential limitations of different scaffold fabrication methods lead to a raised awareness of the challenges research face in dealing with osteoporotic fracture. Advances in 3D printing techniques are providing the ways to manufacture improved, complex, and specialized 3D scaffolds, capable of delivering therapeutic factors directly at the osteoporotic skeletal defect site with predefined rate which is essential in order to optimize the osteointegration/healing rate. Among these factors, strontium has the potential to increase osseointegration, osteogenesis, and healing rate. Strontium ranelate as well as other biological active agents are known to be effective in treating osteoporosis due to both anti-resorptive and anabolic properties but has adverse effects that can be reduced/avoided by local release from biomaterials. In this manner, incorporation of these agents in polymer-ceramic composites bone scaffolds can have significant clinical applications for the recovery of fractured osteoporotic bones limiting or removing the risks associated with systemic administration.

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Section: Biomaterials Scaffoldsmentioning

confidence: 99%

Section: Drug Deliverymentioning

confidence: 99%

Advances in Osteoporotic Bone Tissue Engineering

Codrea

Croitoru

Baciu

et al. 2021

JCM

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“…Microfluidic technologies have recently emerged as a method to make microparticles with a narrow size distribution . Some pertinent examples include the fabrication of PCL/PLA Janus particles as drug carriers as well as PCL/PGLA/PCL Rhodamine B-loaded fibrous scaffolds with drug releasing capabilities. , Microfluidic devices consist of a network of micrometer scale channels for the control of small volumes of fluids (between 10 –9 and 10 –18 L) . Usually, aqueous droplets are formed in a continuous immiscible phase. , The size of the droplets formed depends on the flow rate ratios between the different phases, the geometry of the junction for droplet creation , and the surface properties of the microfluidic devices.…”

Section: Introductionmentioning

confidence: 99%

“…5 Some pertinent examples include the fabrication of PCL/PLA Janus particles as drug carriers as well as PCL/PGLA/PCL Rhodamine B-loaded fibrous scaffolds with drug releasing capabilities. 11,12 Microfluidic devices consist of a network of micrometer scale channels for the control of small volumes of fluids (between 10 −9 and 10 −18 L). 13 Usually, aqueous droplets are formed in a continuous immiscible phase.…”

Section: ■ Introductionmentioning

confidence: 99%

Microfluidic Generation of Therapeutically Relevant Polycaprolactone (PCL) Microparticles: Computational and Experimental Approaches

Forigua

Dalili

Kirsch

et al. 2022

ACS Appl. Polym. Mater.

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Drug releasing microparticles play an important role in drug delivery as they can be used for site specific delivery as well as control over the release time of therapeutics. The use of microfluidic technologies for the fabrication of these particles is of increasing interest since they provide enhanced control over microparticle size and size distribution compared to bulk production methods. However, the use of microfluidic platforms in the production of drug releasing microparticles with therapeutically relevant cargo still requires optimization depending on their application, and the effect of the addition of cargo on the production process is still unexplored. Here we show the formation of therapeutically relevant (in terms of size and dose of cargo) polycaprolactone (PCL) microparticles using a microfluidic platform and analyze the effect of the addition of cargo in the microparticle size and size distribution. This microfluidic platform was designed with the aid of computational fluid dynamic simulations, allowing us to construct a polydimethylsiloxane (PDMS) microfluidic device capable of making microparticles in the range of 15 to 35 μm with low coefficient of variation (CV) both with and without cargo by varying the flow rate ratios of the phases used during droplet generation. Our data show the effect of the addition of cargo on the droplet and microparticle sizes and monodispersity. Our fabrication method allows the formation of spherical microparticles, optimal for biomedical applications. In addition, our microfluidic platform can maintain the generation of monodisperse droplets (with an average size of 52.5 μm) over extended periods of time, suggesting it has the capacity to be used for scaled-up production of PCL microparticles. This microfluidic device is a robust and reliable method for the fabrication of PCL microparticles with cargo, which can potentially be loaded with other relevant therapeutic molecules for biomedical applications.

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“…The skeleton microsphere was formed by dissolving or dispersing the drug in the polymer matrix. Ideally, the particle size should be less than 200 μm 1,2 . As a drug carrier, it has excellent loading efficiency and can control the drug release rate to achieve the long‐term sustained release 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Phosphoglyceride‐coated polylactic acid porous microspheres and its regulation of curcumin release behavior

Shen

Ning

et al. 2022

J of Applied Polymer Sci

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Polymer microspheres are widely used as carriers in delivering of hydrophobic or hydrophilic drugs. Surface coating of microspheres could be one of the attractive strategies to improve their properties. In this study, biodegradable polymer polylactic acid was dissolved in chloroform and non-solvent to electrospray porous polymer microspheres. The properties of the microspheres were improved by phosphoglyceride (P-P-Gly) coating, and its behavior was investigated by loading with curcumin as a model drug. The morphologies of different microspheres were observed by scanning electron microscope. The results indicated that the microspheres obtained by dimethyl sulfoxide as nonsolvent could form the structure with porous characteristics. X-ray diffraction, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy analysis revealed that P-P-Gly was successfully coated on the surface of the microspheres. In addition, the thermal behavior of the coated microspheres was investigated by differential scanning calorimetry. In vitro release experiments indicated that the drug-loaded microspheres showed a very gentle release trend, which was mainly due to the P-P-Gly coating could not completely cover the pores of the microspheres. The P-P-Gly-coated microspheres prepared in this work can be used as controlled release drug carriers with special needs.

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Optimization of Biodegradable PLA/PCL Microspheres Preparation as Controlled Drug Delivery Carrier

Cited by 8 publications

References 9 publications

Advances in Osteoporotic Bone Tissue Engineering

Advances in Osteoporotic Bone Tissue Engineering

Microfluidic Generation of Therapeutically Relevant Polycaprolactone (PCL) Microparticles: Computational and Experimental Approaches

Phosphoglyceride‐coated polylactic acid porous microspheres and its regulation of curcumin release behavior

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