Optimization of bioactive compounds extraction assisted by microwave parameters from Kappaphycus alvarezii using RSM and ANFIS modeling

Baskararaj, Suraj; Panneerselvam, Theivendren; Palanisamy, Ponnusamy; Kannan, S.; Pavadai, Parasuraman; Arunachalam, Sankarganesh; Murugesan, Sankaranarayanan; Mohan, Uma Priya; Ramasamy, Lokesh Kumar; Kunjiappan, Selvaraj

doi:10.1007/s11694-019-00198-1

Cited by 25 publications

(12 citation statements)

References 38 publications

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“…In the literature, there are two types of mathematical models dedicated to microwave extraction: theoretical models based on chemical engineering principles about solid–liquid diffusion [ 39 , 40 , 41 , 42 ] and empirical statistical models based mostly on Response Surface Methodology (RSM) [ 17 , 31 , 43 , 44 , 45 ] but also on Adaptive Neuro-Fuzzy Inference System (ANFIS) statistical methodology [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Optimization of Vacuum-Microwave-Assisted Extraction of Natural Polyphenols and Flavonoids from Raw Solid Waste of the Orange Juice Producing Industry at Industrial Scale

et al. 2021

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Orange pomace (OP) is a solid waste produced in bulk as a byproduct of the orange juice industry and accounts for approximately 50% of the quantity of the fruits processed into juice. In numerous literature references there is information about diverse uses of orange pomace for the production of high-added-value products including production of natural antioxidant and antimicrobial extracts rich in polyphenols and flavonoids which can substitute the hazardous chemical antioxidants/antimicrobials used in agro-food and cosmetics sectors. In this work and for the first time, according to our knowledge, the eco-friendly aqueous vacuum microwave assisted extraction of orange pomace was investigated and optimized at real industrial scale in order to produce aqueous antioxidant/antimicrobial extracts. A Response Surface Optimization methodology with a multipoint historical data experimental design was employed to obtain the optimal values of the process parameters in order to achieve the maximum rates of extraction of OP total polyphenols and/or total flavonoids for economically optimum production at industrial scale. The three factors used for the optimization were: (a) microwave power (b) water to raw pomace ratio and (c) extraction time. Moreover, the effectiveness and statistical soundness of the derived cubic polynomial predictive models were verified by ANOVA.

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Section: Discussionmentioning

confidence: 99%

Optimization of Vacuum-Microwave-Assisted Extraction of Natural Polyphenols and Flavonoids from Raw Solid Waste of the Orange Juice Producing Industry at Industrial Scale

et al. 2021

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“…The oven temperature was initially set at 60 C, then raised at a rate of 5 C/min to 200 C, accompanied by a final rise to 280 C. The scan was done with a m/z range of 50-650. The mass spectrometer was set to 70 eV, and the NIST library was used to identify mass fragmentation trends of individual phytochemical compounds [18].…”

Section: Gas Chromatography-mass Spectrometry For Phytochemical Analysismentioning

confidence: 99%

Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications

Rajagopal¹,

Nivetha

Sundar³

et al. 2021

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The synthesis of copper nanoparticles (CuNPs) using Wrightia tinctoria (Wt) R.Br extract is defined in this article as being convenient, environmentally friendly, and non-toxic. UV-visible spectrophotometry, FT-IR, XRD, particle size analyser, SEM-EDAX and TEM methods were used to describe the physicochemical properties of Wt extract mediated synthesized CuNPs (Wt-CuNPs). The Wt-CuNPs synthesized was found to be monodispersed and spherical, with an average size of 15 nm. Gas chromatography and mass spectrometry (GC-MS) research revealed that the Wt R.Br plant extract contains various phytochemical compounds. The properties of Wt-CuNPs were verified by the findings of characterization tests. Via in silico molecular docking experiments with established targets, the underlying mechanisms of cytotoxicity against breast cancer and larvicidal behaviour against Aedes aegypti of Wt-CuNPs were investigated. Interestingly, in vitro cytotoxicity studies showed 50% cell death (IC 50 ) of Wt-CuNPs treated MCF-7 cells and Vero Cells (Kidney epithelial cells) were displayed at 119.23 μg.mL À1 and 898.75 μg.mL À1 , respectively. Also, Wt-CuNPs showed least LC 50 and LC 90 values for larvicidal activity against A. aegypti were of 32.10 μg.mL À1 and 21.70 μg.mL À1 , respectively. Furthermore, Wt-CuNPs is found to be less toxic and biocompatible in haemolytic assays. The findings clearly showed that biosynthesized Wt-CuNPs have been used as a possible anticancer and larvicidal agent, as well as being environmentally friendly.

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“…Vacuum-microwave-assisted extraction is a typical paradigm of a solid–liquid extraction and many researchers have developed models for the prediction of the concentration or alternatively of the amount of the extracted bioactive compounds. In general, there are two types of mathematical models dedicated to microwave extraction: theoretical models based on chemical engineering principles of solid–liquid diffusion [ 52 , 53 , 54 , 55 ] and empirical statistical models based mostly on response surface methodology (RSM) [ 56 , 57 , 58 , 59 , 60 ] but also on adaptive neuro-fuzzy inference system (ANFIS) statistical methodology [ 61 , 62 ]. From the abovementioned models, the theoretical ones are not very useful in the case we need to obtain the optimum conditions for industrial-scale optimization of the VMAE extraction of bioactive phytochemicals.…”

Section: Discussionmentioning

confidence: 99%

Optimization of the Vacuum Microwave Assisted Extraction of the Natural Polyphenols and Flavonoids from the Raw Solid Waste of the Pomegranate Juice Producing Industry at Industrial Scale

et al. 2021

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Pomegranate pomace (PP) is the solid waste produced in bulk by the pomegranate juice industry which is rich in polyphenols and flavonoids that can replace the hazardous chemical antioxidants/antimicrobials currently used in the agro-food and cosmetics sectors. In the present work, the vacuum microwave assisted extraction (VMAE) of natural antioxidants from raw pomegranate pomace was investigated and successfully optimized at an industrial scale. For the optimization of PP VMAE a novel, highly accurate response surface methodology (RSM) based on a comprehensive multi-point historical design was employed. The optimization showed that the maximum recovery of PP total polyphenols as well as total PP flavonoids were obtained at microwave power = 4961.07 W, water to pomace ratio = 29.9, extraction time = 119.53 min and microwave power = 4147.76 W, water to pomace ratio = 19.32, extraction time = 63.32 min respectively. Moreover, the optimal VMAE conditions on economic grounds were determined to be: microwave power = 2048.62 W, water to pomace ratio = 23.11, extraction time = 15.04 min and microwave power = 4008.62 W, water to pomace ratio = 18.08, extraction time = 15.29 min for PP total polyphenols and PP total flavonoids respectively. The main conclusion of this study is that the VMAE extraction can be successfully used at industrial scale to produce, in economic manner, high added value natural extracts from PP pomace.

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Optimization of bioactive compounds extraction assisted by microwave parameters from Kappaphycus alvarezii using RSM and ANFIS modeling

Cited by 25 publications

References 38 publications

Optimization of Vacuum-Microwave-Assisted Extraction of Natural Polyphenols and Flavonoids from Raw Solid Waste of the Orange Juice Producing Industry at Industrial Scale

Optimization of Vacuum-Microwave-Assisted Extraction of Natural Polyphenols and Flavonoids from Raw Solid Waste of the Orange Juice Producing Industry at Industrial Scale

Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications

Optimization of the Vacuum Microwave Assisted Extraction of the Natural Polyphenols and Flavonoids from the Raw Solid Waste of the Pomegranate Juice Producing Industry at Industrial Scale

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