Optimization of antifungal activity of Aeollanthus heliotropioides oliv essential oil and Time Kill Kinetic Assay

Agnaniet, Huguette; Nguimatsia, François; Dongmo, Pierre Michel Jazet; Fokou, Jean Baptiste Hzounda; Bakarnga-Via, Issakou; Boyom, Fabrice Fekam; Menut, Chantal

doi:10.1016/j.mycmed.2016.04.003

Cited by 11 publications

(7 citation statements)

References 35 publications

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“…These results corroborate other reports 16 , which obtained a yield substantially close (0.07%). However, there is a difference with the results from other studies with a yield of 1.3% 29 .…”

Section: Extraction Yields Of the Essential Oil And Solvent Extractssupporting

confidence: 93%

“…The essential oil analysis by GC/MC highlighted linalool (43.47%) and cis-α-farnesene (42.67%) as major compounds. These compounds were the same as those obtained in the review; 38.5% for linalool and 25.1% for cis-α-farnesene 16 then 34.9% and 29.1% for linalool and farnesene 29 . This difference could be explained by the geographical origin of the plant, the organ used for the extraction (leaf, stems, or flowers...), the environmental factors, and the extraction process applied to the plant 30 .…”

Section: Phytochemical Screening Of Stem Leaf and Flower Hydroethanolic Extractssupporting

confidence: 70%

“…ex Spreng is a traditional condiment used to season roasted fish and meat. The therapeutic properties of A. heliotropioides such as antimicrobial and antioxidant have been demonstrated [16][17][18] . However, antibacterial modes of action on this plant are not well studied.…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial activities of the essential oil and hydroethanolic extract from Aeollanthus heliotropioides Oliv

et al. 2021

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To contribute to control bacterial infections, we proposed evaluating the antibacterial activities and modes of action of Aeollanthus heliotropioides essential oil and its hydroethanolic extract. Solvent extracts and essential oil were obtained from the aromatic plant's aerial parts by hydroethanolic maceration and hydro-distillation. The analyses of the chemical composition were performed using gas chromatography coupled with mass spectrometry. The microdilution method evaluated the in vitro antibacterial potential of the essential oil and solvent extracts. The Inhibition of biofilms formation was carried out using a colorimetric biofilm microdilution assay with crystal violet as a dye. The effect of extract and essential oil on the release of nucleic acids was performed using a spectrophotometric method. The time-kill kinetic assay was assessed for hydroethanolic extracts and essential oil. The extraction yield was 0.1%, and the major compounds identified in the essential oil were linalool (43.47%) and cis-α-farnesene (42.67%). The phytochemical screening revealed flavonoids, saponins, phenols, triterpenes, catechin tannins, and quinones. Minimum Inhibitory Concentrations (MICs) ranged from 2.08 mg/mL to 10 mg/mL. Concerning the modes of action, the essential oil showed its bactericidal effect at 2 hours. The reduction of Escherichia coli biofilms formation was found at 0.21 mg/mL. The essential oil treatments resulted in a release of nucleic acids at a concentration of 2.1 mg/mL. These results justify using the essential oil and hydroethanolic extracts of Aeollanthus heliotropioides as a potential source of molecules with antibacterial activity.

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Section: Extraction Yields Of the Essential Oil And Solvent Extractssupporting

confidence: 93%

Section: Phytochemical Screening Of Stem Leaf and Flower Hydroethanolic Extractssupporting

confidence: 70%

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Antibacterial activities of the essential oil and hydroethanolic extract from Aeollanthus heliotropioides Oliv

et al. 2021

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“…A recent study of Zain et al (2019) also tested the antibacterial activity of the pitaya (H. polyrhizus) peel extract and found a small antibacterial effect on the Gram-positive and Gram-negative bacteria, S. aureus and E. coli, respectively. The authors concluded that despite the small antibacterial effect of the pitaya peel extract, the results were consistent with previous works which considered that it was yet sufficient to support its use as a natural colour source and antibacterial agent in food and cosmetic products (Majhenič et al 2007;Guo et al 2011;Mback et al 2016).…”

Section: Reviewsupporting

confidence: 87%

Dragon fruit: A review of health benefits and nutrients and its sustainable development under climate changes in Vietnam

Luu¹,

Le²,

Huynh³

et al. 2021

Czech J. Food Sci.

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Dragon fruit or pitaya is an exotic tropical plant that brings multiple benefits to human health thanks to its high nutritional value and bioactive compounds, including powerful natural antioxidants. Extracts from stems, flowers, peels, pulps of dragon fruit own a range of beneficial biological activities against pathogenic microbes including bacteria, fungi and viruses, and diseases like diabetes, obesity, hyperlipidaemia, and cancer. Moreover, dragon fruit extracts have cardiovascular and hepatoprotective properties, as well as prebiotic potential. Vietnam is a tropical country with favourable climate conditions for the development of pitaya plantations, which have great adaptability and tolerance to a wide range of environmental conditions (e.g. salinity adaptation, favour light intensity, drought resistance, etc.). The dragon fruit, thanks to its nutritional properties, biological activities, and commercial value has become a cost-effective product for the Vietnamese economy, particularly in the poorest areas of the Mekong Delta region, and a driving force in the sustainable development of Vietnam under the challenges posed by the global climate change such as saline intrusion and drought.

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“…The obtained results validate the implementation of studies with a biotechnological approach for a better use of the antimicrobial properties of the thymol, menthol, and eucalyptol compounds in the control of microbial agents that alter the homeostasis of the oral cavity; however, it is extremely important to take into account a few aspects that maximize the effectiveness and safety of the supplies, such as equivalence of the in vitro and in vivo antimicrobial activity, toxicity, mechanisms of action, and the specificity of the application pathway [12]; also, it should be kept in mind that while this study aimed to analyze each compound to determine their potential as active ingredients [15,34,86], it is important to conduct mixes with other substances and to evaluate the synergistic, neutral, antagonistic, and additive associations that may arise, taking into account the proportions and nature of the mixed substances [12,68], as phytochemicals can enhance their effect in the presence of other substances [64,77,90], but the effect can also be reduced [16,26] or even certain combinations may prove to be unnecessary [16].…”

Section: Discussionmentioning

confidence: 99%

Thymol, menthol and eucalyptol as agents for microbiological control in the oral cavity: A scoping review

Pabón¹,

Ortega-Cuadros²

2020

Rev. Colomb. Cienc. Quím. Farm.

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Dental plaque is a complex environment that maintains a balance with certain microbial communities; however, this microhabitat can be disturbed by some endogenous species causing disease. An exploratory systematic review was carried out using the PubMed, Scopus, Lilacs, and Science Direct databases, identifying that the thymol, menthol, and eucalyptol compounds present varying antimicrobial activity, intra- and interspecies discordance, and a strong antimicrobial intensity on Aggregatibacter actinomycetemcomitans, Candida albicans, Candida dubliniensis, Enterococcus faecalis, Escherichia coli, Lactobacillus plantarum, and Streptococcus mutans, indicating that these phytochemicals can be considered broad-spectrum antimicrobial substances, with an effect on microorganisms linked to oral diseases.

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Optimization of antifungal activity of Aeollanthus heliotropioides oliv essential oil and Time Kill Kinetic Assay

Cited by 11 publications

References 35 publications

Antibacterial activities of the essential oil and hydroethanolic extract from Aeollanthus heliotropioides Oliv

Antibacterial activities of the essential oil and hydroethanolic extract from Aeollanthus heliotropioides Oliv

Dragon fruit: A review of health benefits and nutrients and its sustainable development under climate changes in Vietnam

Thymol, menthol and eucalyptol as agents for microbiological control in the oral cavity: A scoping review

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