Optimization of Anti-Cancer Gamavuton-0 Synthesis Using Box Behnken Experimental Design

Harimurti, Sabtanti; Widada, Hari; Kadarinah, Sri; Hadi, Ismanurrahman; Wijaya, Didy Putra; Komarudin, Komarudin; Rifai, Maulana Akbar

doi:10.1166/asl.2017.10801

Cited by 2 publications

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“…It is reported in the previous study, the curcumine derivative 1,5-bis (4'-hidroksi-3'-metoksifenil)-1,4-pentadien-3one) or gamavuton-0 was synthesized in the round bottle flask using conventional heating (heating mantel). This method usually takes long time and consume a lot of energy to obtain the high yield [10]. Thus based on the previous work, this paper deals with the explanation of the effectiveness of gamavuton-0 synthesis using microwave irradiation compared to the conventional method.…”

Section: Introductionmentioning

confidence: 99%

Energy Savings on Curcumine Derivative Gamavuton-0 Synthesis Using Microwave Irradiation

Harimurti

Nugroho²,

Pramono

2019

Int J App Pharm

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Objective: The aim of this study was to develop a more effective and environmentally friendly synthesis method for anti-cancer curcumine derivatives, namely 1,5-bis (4’-hydroxy-3’-metoxyfenyl)-1,4-pentadiene-3-one or gamavuton-0. Methods: The experiment was conducted using two different energy sources, i.e. conventional heating and microwave irradiation. Vanillin and acetone were used as starting materials, and hydrochloric acid as the catalyst. During synthesis, variations in the synthesis period were carried out to study the effect of time on the gamavuton-0 produced. Based on experimental data, energy consumption between conventional method and microwave were evaluated. Results: Evaluation of energy consumption was calculated based on experimental data. It was found that energy consumption for production using microwave irradiation was reduced to 0.0014 kWh/gram of crude gamavuton-0 products from 0.19 KWh/gram of crude gamavuton-0 product using conventional heating. Conclusion: Based on calculations from experimental data, microwave irradiation during the synthesis of gamavuton-0 significantly saves energy consumption for synthesis.

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Section: Introductionmentioning

confidence: 99%