Optimization of acetic acid production from synthesis gas by chemolithotrophic bacterium – Clostridium aceticum using statistical approach

Sim, Jia Huey; Kamaruddin, Azlina Harun

doi:10.1016/j.biortech.2007.07.004

Cited by 52 publications

(19 citation statements)

References 11 publications

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“…with 100% CO conversion [138]. M. thermoacetica is considered a model acetogen [139] and it was used by Wood and Ljungdahl and later by Ragsdale and others to elucidate the Wood-Ljungdahl pathway [85].…”

Section: Acetate Producersmentioning

confidence: 99%

Commercial Biomass Syngas Fermentation

2012

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Abstract:The use of gas fermentation for the production of low carbon biofuels such as ethanol or butanol from lignocellulosic biomass is an area currently undergoing intensive research and development, with the first commercial units expected to commence operation in the near future. In this process, biomass is first converted into carbon monoxide (CO) and hydrogen (H 2 )-rich synthesis gas (syngas) via gasification, and subsequently fermented to hydrocarbons by acetogenic bacteria. Several studies have been performed over the last few years to optimise both biomass gasification and syngas fermentation with significant progress being reported in both areas. While challenges associated with the scale-up and operation of this novel process remain, this strategy offers numerous advantages compared with established fermentation and purely thermochemical approaches to biofuel production in terms of feedstock flexibility and production cost. In recent times, metabolic engineering and synthetic biology techniques have been applied to gas fermenting organisms, paving the way for gases to be used as the feedstock for the commercial production of increasingly energy dense fuels and more valuable chemicals.

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Section: Acetate Producersmentioning

confidence: 99%

Commercial Biomass Syngas Fermentation

2012

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“…Another study showed that the addition of Na 2 S had no effect on the growth of Clostridium aceticum [7]. Furthermore, the reported optimal sulfide concentrations used in fermentations varied greatly, ranging from 1.3 to 136 mM [1][2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Sulfide assessment in bioreactors with gas replacement

Jacobsen

Horton

et al. 2010

Biochemical Engineering Journal

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“…Various process optimization strategies were developed by scientists and the most frequently used optimization strategy is "one-at-a-time" strategy (Dutta et al 2004). This classical method is not only time consuming, but also does not depict the combined interactions between physiochemical parameters and may lead to misinterpretation of results (Baş and Boyaci, 2007;Sim and Kamaruddin, 2008). To overcome these problems, modern optimization systems are employed.…”

Section: Introductionmentioning

confidence: 99%

Thermostable lipase from a newly isolated Staphylococcus xylosus strain; process optimization and characterization using RSM and ANN

Khoramnia¹,

Lai²,

Ebrahimpour³

et al. 2010

Electron. J. Biotechnol.

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Normal feed forward back-propagation artificial neural network (ANN) and cubic backward elimination response surface methodology (RSM) were used to build a predictive model of the combined effects and optimization of culture parameters for the lipase production of a newly isolated Staphylococcus xylosus. The results demonstrated a high predictive accuracy of artificial neural network compared to response surface methodology. The optimum operating condition obtained from the ANN model was found to be at 30ºC incubation temperature, pH 7.5, 60 hrs incubation period, 1.8% inoculum size and 60 rpm agitation. The lipase production increased 3.5 fold for optimal medium. The produced enzyme was characterized biochemically and this is the first report about a mesophilic staphylococci bacterium with a high thermostable lipase which is able to retain 50% of its activity at 70ºC after 90 min and at 60ºC after 120 min. This lipase is also acidic and alkaline resistant which remains active after 24 hrs in a broad range of pH (4-11).

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Optimization of acetic acid production from synthesis gas by chemolithotrophic bacterium – Clostridium aceticum using statistical approach

Cited by 52 publications

References 11 publications

Commercial Biomass Syngas Fermentation

Commercial Biomass Syngas Fermentation

Sulfide assessment in bioreactors with gas replacement

Thermostable lipase from a newly isolated Staphylococcus xylosus strain; process optimization and characterization using RSM and ANN

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