Optimization of 124I production via 124Te(p,n)124I reaction

Sajjad, Munawwar; Bars, Erol; Nabi, Hani A.

doi:10.1016/j.apradiso.2006.04.004

Cited by 31 publications

(23 citation statements)

References 15 publications

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“…For 124 I-labeling, trimethylstannyl derivatives 9 , 11 and 12 were separately reacted for 15 minutes at room temperature with NaI 124 (produced in UB cyclotron facility19 in the presence of 1,3,4,6-tetrachloro-3alpha,6alpha-diphenylglucoluril. After 15 minutes the bead was removed and radioactive reaction mixture was purified by HPLC.…”

Section: Results and Discussion Chemistry/radiochemistrymentioning

confidence: 99%

Comparative Positron-Emission Tomography (PET) Imaging and Phototherapeutic Potential of ¹²⁴I- Labeled Methyl- 3-(1′-iodobenzyloxyethyl)pyropheophorbide-a vs the Corresponding Glucose and Galactose Conjugates

et al. 2008

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In our present study, 3-(1′-m-iodobenzyloxyethyl) pyropheophorbide-a methyl ester 1, 3-(1′-m-iodobenzyloxyethyl)-172-{(2-deoxy)glucose} pyropheophorbide-a 2, and 3-(1′-m-iodo benzyloxyethyl)-172-{(1-deoxy)galactose} pyropheophorbide-a 3 were synthesized and converted into the corresponding 124I- labeled analogs by reacting the intermediate trimethyltin analogs with Na124I. Photosensitizers 1–3 were evaluated for the PDT efficacy in C3H mice bearing RIF tumors at variable doses and showed a significant long-term tumor cure. Among the compounds investigated, the non-carbohydrate analog 1 was most effective. These results were in contrast to the in vitro data, where compared to the parent analog the corresponding galactose-and glucose derivatives showed enhanced cell kill. Among the corresponding 124I-labeled in analogs, excellent tumor images were obtained from compound 1 both tumor models (RIF and Colon-26) and the best tumor contrast was observed at 72 h post injection. Conjugating a glucose moiety to photosensitizer 1 diminished its tumor uptake, whereas with time the corresponding galactose analog showed improved tumor contrast.

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Section: Results and Discussion Chemistry/radiochemistrymentioning

confidence: 99%

Comparative Positron-Emission Tomography (PET) Imaging and Phototherapeutic Potential of ¹²⁴I- Labeled Methyl- 3-(1′-iodobenzyloxyethyl)pyropheophorbide-a vs the Corresponding Glucose and Galactose Conjugates

et al. 2008

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“…Synthesis of PS2 ( 124 I-analog of PS1): Iodine-124 was produced in our facility via 124 Te(p,n) 124 I reaction 25. The 124 TeO target was irradiated by 14.1 MeV protons beam and the 124 I produced was purified by dry distillation.…”

Section: Methodsmentioning

confidence: 99%

Polyacrylamide-Based Biocompatible Nanoplatform Enhances the Tumor Uptake, PET/fluorescence Imaging and Anticancer Activity of a Chlorophyll Analog

Gupta¹,

Wang²,

Marko³

et al. 2014

Theranostics

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In this report we demonstrate the outstanding advantages of multifunctional nanoplatforms for cancer-imaging and therapy. The non-toxic polyacrylamide (PAA) nanoparticles (size:18-25 nm) formulation drastically changed the pharmacokinetic profile of the 124I- labeled chlorophyll-a derivative (formulated in 10% ethanol in PBS) with a remarkable enhancement in tumor uptake, and significantly reduced uptake in spleen and liver. Among the various nanoformulations investigated, the 124I- labeled photosensitizer (dose: 0.6142 MBq), and the cyanine dye-nanoparticles (CD-NP) conjugate (dose 0.3 μmol/kg) in combination showed great potential for tumor imaging (PET/NIR fluorescence) in BALB/c mice bearing Colon26 tumors. Compared to free non-labeled photosensitizer, the corresponding PAA nanoformulation under similar treatment parameters showed a remarkable enhancement in long-term tumor cure by PDT (photodynamic therapy) and provides an opportunity to develop a single nanoplatform for tumor-imaging (PET/fluorescence) and phototherapy, a practical “See and Treat” approach.

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“…124 I was produced by the 124 Te (p, n) 124 I reaction [28]. A 124 TeO 2 (tellurium oxide) target was irradiated by 14.1 MeV protons at 24 μA a Cyclone-30 cyclotron (IBA, Louvain-la-Neuve, Belgium).…”

Section: Methodsmentioning

confidence: 99%

Expression of HMP/AN2, a melanoma associated antigen, in murine cerebral gliomas: potential for radioimmunotargeting

et al. 2009

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Human melanoma proteoglycan (HMP), a melanoma-associated antigen, is expressed in both human melanomas and gliomas. We used HMP-specific monoclonal antibody (mAb) VT68.2 to investigate whether murine GL261 cerebral gliomas express the HMP homologue AN2 and to determine whether AN2 could be targeted for selective delivery of radiation in vivo. HMP-specific mAb VT68.2 stained murine GL261 glioma cells grown in culture and intracerebrally in syngeneic C57BL/6 mice. Positron emission tomography with radiolabeled mAb VT68.2 showed high-contrast, positive images of gliomas against a negative background. At 96 h after injection, glioma uptake of radiolabeled mAb VT68.2 was 10 times greater than that of the isotype control mAb and 20 times greater than that detected in normal cerebral tissue. Our results show murine GL261 cerebral gliomas express AN2 and HMP-specific mAb VT68.2 accumulates selectively and specifically at high concentration and is retained within murine cerebral gliomas. Thus, HMP is a potential target for antibody-mediated selective delivery of radiation to cerebral gliomas in vivo.

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Optimization of 124I production via 124Te(p,n)124I reaction

Cited by 31 publications

References 15 publications

Comparative Positron-Emission Tomography (PET) Imaging and Phototherapeutic Potential of ¹²⁴I- Labeled Methyl- 3-(1′-iodobenzyloxyethyl)pyropheophorbide-a vs the Corresponding Glucose and Galactose Conjugates

Comparative Positron-Emission Tomography (PET) Imaging and Phototherapeutic Potential of ¹²⁴I- Labeled Methyl- 3-(1′-iodobenzyloxyethyl)pyropheophorbide-a vs the Corresponding Glucose and Galactose Conjugates

Polyacrylamide-Based Biocompatible Nanoplatform Enhances the Tumor Uptake, PET/fluorescence Imaging and Anticancer Activity of a Chlorophyll Analog

Expression of HMP/AN2, a melanoma associated antigen, in murine cerebral gliomas: potential for radioimmunotargeting

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Optimization of 124I production via 124Te(p,n)124I reaction

Cited by 31 publications

References 15 publications

Comparative Positron-Emission Tomography (PET) Imaging and Phototherapeutic Potential of 124I- Labeled Methyl- 3-(1′-iodobenzyloxyethyl)pyropheophorbide-a vs the Corresponding Glucose and Galactose Conjugates

Comparative Positron-Emission Tomography (PET) Imaging and Phototherapeutic Potential of 124I- Labeled Methyl- 3-(1′-iodobenzyloxyethyl)pyropheophorbide-a vs the Corresponding Glucose and Galactose Conjugates

Polyacrylamide-Based Biocompatible Nanoplatform Enhances the Tumor Uptake, PET/fluorescence Imaging and Anticancer Activity of a Chlorophyll Analog

Expression of HMP/AN2, a melanoma associated antigen, in murine cerebral gliomas: potential for radioimmunotargeting

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Product

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Comparative Positron-Emission Tomography (PET) Imaging and Phototherapeutic Potential of ¹²⁴I- Labeled Methyl- 3-(1′-iodobenzyloxyethyl)pyropheophorbide-a vs the Corresponding Glucose and Galactose Conjugates

Comparative Positron-Emission Tomography (PET) Imaging and Phototherapeutic Potential of ¹²⁴I- Labeled Methyl- 3-(1′-iodobenzyloxyethyl)pyropheophorbide-a vs the Corresponding Glucose and Galactose Conjugates