Optimization and preparation of Methylcellulose edible film combined with of Ferulago angulata essential oil (FEO) nanocapsules for food packaging applications

Abstract

The films based on methylcellulose with biodegradable and antioxidant activity incorporated with nano capsule suspension containing F. angulata essential oil were developed. Oil extraction and identification of F. angulata essential oil compounds was done. Nano capsule suspension containing F. angulata essential oil was prepared by ultrasonic bath. The films were prepared by a casting method in three different ratios. The mechanical properties, colour, light transmission, antioxidant activity and release rate characteristics of the films were studied. The addition of nano capsule suspension to methylcellulose films decreased the thickness, tensile strength but increased the percentage elongation at break (%E) and lightness. High antioxidant activity and a prolonged release of F. angulata essential oil were also reported. Five factors design of Response Surface Methodology were used to optimize the thickness, holding time and anti-oxidant effect of edible film based on methylcellulose incorporated with nano capsule suspension containing F. angulata essential oil. Design of experiments was carried out by the software: Minitab 17 (Sigma package). Optimization of thickness, 2, 2-diphenyl-1-picrylhydrazyl radical scavenging and holding time would yield the best mixture proportions of methylcellulose and nano capsule suspension 30%, 30% and 70%; oil<0.05, 0.07 and 0.05 mg; at 20, 24 and 24 min; 50°, 40°, 50°C were obtained respectively.

Progress of nanopreparation technology applied to volatile oil drug delivery systems

“…This technology can effectively reduce volatilization losses, slow down the rate of volatilization, and improve the effectiveness of its application and product quality in different fields. There are various options for encapsulating volatile oils into nanoscale particles, including polymer-based nanocarriers (microemulsions, nanoemulsions [ 7 ], liposomes [ 8 ], solid lipid nanoparticles, nanostructured lipid carriers, self-nanoemulsifying drug delivery systems), lipid-based nanocarriers (nanocapsules [ 9 ], nanomicelles). There are also multiple choices for nanoscale formulation technologies, mainly including self-nanoemulsification [ 10 ], phase inversion [ 11 ], high-speed shearing technology, spray drying method, high-pressure homogenization, ultrasonic technology [ 12 ], thin film hydration method, ethanol injection technology, nanoprecipitation technology, electrospinning, emulsion diffusion method, ion gelation.…”