Progress of nanopreparation technology applied to volatile oil drug delivery systems

Ye, Zu-Wen; Yang, Qi-Yue; Lin, Qiao-Hong; Liu, Xiao-Xia; Li, Feng-Qin; Xuan, Hong-Da; Bai, Ying-Yan; Huang, Ya-Peng; Wang, Le; Wang, Fang

doi:10.1016/j.heliyon.2024.e24302

Cited by 3 publications

(1 citation statement)

References 207 publications

(352 reference statements)

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“…Another delivery route is directly to the lungs, using an inhaler -although this method is yet to be proven safe and should be tested in vivo. In addition, promising innovative approaches aimed at delivering volative drugs, such as nanoemulsion, nanopreparations, and nanocarriers, are currently under investigation [25][26][27] . If proven effective, they may be suitable for Cinnamo-mum cassia.…”

Section: Cinnamomum Cassia a Non-toxic Potential Alternative To Curre...mentioning

confidence: 99%

Cinnamomum cassia and Origanum compactum Essential Oils as Antifungal Candidates for the Treatment of Aspergillosis

Leclercq,

Commenge,

Bouriot

et al. 2024

MSURJ

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Aspergillosis is a disease that usually affects the respiratory system. While most patients develop mild symptoms, aspergillosis can become a serious health threat in immunocompromised populations and patients with pre-existing respiratory conditions. Aspergillosis is caused by fungi of the Aspergillus genus. Existing treatments include drugs such as azoles, ergosterol interfering agents (Amphotericin B), and echinocandins (Caspofungin), which usually come with various drawbacks. Numerous studies have shown the antifungal properties of certain essential oils (EOs), which represent potential alternative treatments against fungal infections. Here, we screened the antifungal properties of five EOs against Aspergillus oryzae: Melaleuca alternifolia, Mentha x piperita, Thymus zygis, Origanum compactum, and Cinnamomum cassia. Of the five EOs, two demonstrated antifungal activity: Origanum compactum acted as a fungistatic, while Cinnamomum cassia showed both fungistatic and fungicidal effects against A. oryzae. Therefore, both EOs represent potential alternative treatments against Aspergillosis.

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Section: Cinnamomum Cassia a Non-toxic Potential Alternative To Curre...mentioning

confidence: 99%

Cinnamomum cassia and Origanum compactum Essential Oils as Antifungal Candidates for the Treatment of Aspergillosis

Leclercq,

Commenge,

Bouriot

et al. 2024

MSURJ

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Antioxidant and anti-Alzheimer's disease activities of 1,8-cineole and its cyclodextrin inclusion complex

Tan,

Xu,

et al. 2024

Biomedicine & Pharmacotherapy

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The Effect of Electrospun Scaffold Loaded With Taraxasterol Microspheres on the Proliferation and Differentiation of Osteoblasts

Zhang,

Shaari,

Awang Nawi

et al. 2024

Cureus

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This study aims to observe the effect of electrospun scaffolds loaded with taraxasterol microspheres on the proliferation and differentiation of osteoblasts. Taraxasterol microspheres were prepared by desolventization and electrostatic adsorption technology. The structure of the microspheres was observed under transmission electron microscopy. The drug microspheres were loaded into electrospinning using electrospinning technology, followed by scanning electron microscopy and elemental analysis. Osteoblasts were cultured in vitro, and the effects of drug carriers on osteoblast proliferation and differentiation were observed through Cell Counting kit 8 (CCK-8) cell proliferation detection and alkaline phosphatase activity detection. Transmission electron microscopy showed that the prepared drug microspheres have a double-layer structure, which can effectively reduce the sudden release of drugs. The electrospinning had a porous three-dimensional structure between them, which was conducive to cell adhesion. After loading microspheres, there was a significant difference in electrospinning diameter and nodular protrusions, energy dispersive spectroscopy (EDS) elemental analysis showed that the proportion of nitrogen elements increased significantly after the addition of microspheres, a CCK-8 detection showed that drug carrier scaffolds loaded with taraxasterol had a promoting effect on osteoblast proliferation (P<0.05). Alkaline phosphatase detection showed that drug carrier scaffolds loaded with taraxasterol can promote early differentiation of osteoblasts (P>0.05). Electrospinning loaded with taraxasterol microspheres can promote osteoblast adhesion, proliferation, and differentiation.

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Progress of nanopreparation technology applied to volatile oil drug delivery systems

Cited by 3 publications

References 207 publications

Cinnamomum cassia and Origanum compactum Essential Oils as Antifungal Candidates for the Treatment of Aspergillosis

Cinnamomum cassia and Origanum compactum Essential Oils as Antifungal Candidates for the Treatment of Aspergillosis

Antioxidant and anti-Alzheimer's disease activities of 1,8-cineole and its cyclodextrin inclusion complex

The Effect of Electrospun Scaffold Loaded With Taraxasterol Microspheres on the Proliferation and Differentiation of Osteoblasts

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